排序方式: 共有173条查询结果,搜索用时 15 毫秒
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Gossec L Smolen JS Gaujoux-Viala C Ash Z Marzo-Ortega H van der Heijde D FitzGerald O Aletaha D Balint P Boumpas D Braun J Breedveld FC Burmester G Cañete JD de Wit M Dagfinrud H de Vlam K Dougados M Helliwell P Kavanaugh A Kvien TK Landewé R Luger T Maccarone M McGonagle D McHugh N McInnes IB Ritchlin C Sieper J Tak PP Valesini G Vencovsky J Winthrop KL Zink A Emery P;European League Against Rheumatism 《Annals of the rheumatic diseases》2012,71(1):4-12
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Gossec L Baro-Riba J Bozonnat MC Daurès JP Sany J Eliaou JF Combe B 《The Journal of rheumatology》2005,32(8):1448-1451
OBJECTIVE: To determine whether patient's sex influences the severity of rheumatoid arthritis (RA) in terms of clinical severity or need for treatments. METHODS: This was a retrospective, single-center study. We compared 133 male patients with 133 female patients presenting with RA and matched for disease duration. Data collection included demographic characteristics, pattern of joint involvement, extraarticular manifestations, medical treatment, and joint surgery. Biological measures, HLA genotypes, Larsen radiological scores on radiographs of hands and feet, and Health Assessment Questionnaire (HAQ) results were obtained. RESULTS: Mean disease duration was 7.4 +/- 6.9 years. Concerning clinical pattern of involvement, sicca syndrome was more frequent in women than in men (p = 0.0003). There were no significant differences concerning absence or presence of at least one disease associated gene (HLA-DRB1*01 or *04) in our patients; however, women more often carried 2 disease associated genes (21% vs 11%). No other difference in clinical, biological, or radiological indicators was noted between the 2 populations. Concerning treatment, there was no difference for large joint arthroplasties; female patients underwent significantly more distal joint arthrodesis, 6.7% vs 1.5% (p = 0.03); they were prescribed slightly more disease modifying drugs, 3.33 vs 2.83 (p = 0.04); and showed a trend toward more large joint arthrodesis, 15% vs 7.5% (p = 0.05), and metacarpophalangeal joint arthroplasties, 5.2% vs 0.7% (p = 0.08). CONCLUSION: When patients are matched for RA duration, sex has little effect on the disease pattern and severity, yet women undergo more distal joint surgery. 相似文献
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Gossec L Le Henanff A Breban M Vignon E Claudepierre P Devauchelle V Wendling D Lespessailles E Euller-Ziegler L Sibilia J Perdriger A Alexandre C Dougados M 《Rheumatology (Oxford, England)》2006,45(7):859-862
OBJECTIVE: To evaluate the continuation and safety of treatment with infliximab in ankylosing spondylitis (AS) over a 2-yr period. METHODS: This study was an open, observational, 2-yr extension study of an open-label study of three induction infusions of infliximab in refractory AS. The fourth infusion was performed only in case of relapse. Thereafter, infliximab was to be administered as needed according to the rheumatologist's opinion; however, for some patients, infusions were performed systematically. RESULTS: None of the 50 recruited patients was lost to follow-up. Thirteen patients (26%) interrupted their treatment by infliximab: four for inefficacy, seven for adverse events, of which four were for allergic reactions to the infusion, and two for other reasons. For all of the 46 patients who had had three infusions judged efficacious and well tolerated, a fourth infusion was performed because of a flare of the disease, after a mean interval of 20.3+/-9.9 weeks (range 7.3-57.9). Over the 24 months, the mean interval between infusions was 11.6+/-9.0 weeks. This interval was longer when patients were treated only as needed (mean 14.3+/-12.1 weeks) than systematically (mean 9.8+/-5.7 weeks). Side-effects were similar to those noted in shorter-term studies; seven patients suffered serious adverse events. There were no deaths, no malignancies and no tuberculosis. CONCLUSION: This study confirms the long-term treatment continuation of infliximab in AS, and shows an acceptable safety profile. It appears that for some patients the disease can be controlled with long intervals between infusions; these findings warrant further studies. 相似文献
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Behrens Frank Leage Soyi Liu Sapin Christophe El Baou Celine De La Torre Inmaculada Meszaros Gabriella Schett Georg Combe Bernard van den Bosch Filip Gossec Laure 《Clinical rheumatology》2021,40(12):4955-4956
Clinical Rheumatology - 相似文献
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Athan Baillet Xavier Romand Arnaud Pflimlin Mickael Dalecky Pascal Claudepierre René-Marc Flipo Adeline Ruyssen-Witrand Philippe Gaudin Laure Gossec Anna Molto Cédric Lukas Sophie Pouplin Martin Soubrier Daniel Wendling Françoise Fayet Christophe Hudry Eric Senbel Marjorie Schwartz Maxime Dougados 《Revue du Rhumatisme》2021,88(2):86-92
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C. Huynh D. Puyraimond-Zemmour J.F. Maillefert P.G. Conaghan A.M. Davis K.-P. Gunther G. Hawker M.C. Hochberg M. Kloppenburg K. Lim L.S. Lohmander N.N. Mahomed L. March K. Pavelka L. Punzi E.M. Roos L. Sanchez-Riera J.A. Singh L. Gossec 《Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society》2018,26(10):1311-1318
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