全文获取类型
收费全文 | 986篇 |
免费 | 44篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 26篇 |
妇产科学 | 8篇 |
基础医学 | 83篇 |
口腔科学 | 22篇 |
临床医学 | 62篇 |
内科学 | 150篇 |
皮肤病学 | 17篇 |
神经病学 | 54篇 |
特种医学 | 15篇 |
外科学 | 143篇 |
综合类 | 119篇 |
预防医学 | 40篇 |
眼科学 | 26篇 |
药学 | 177篇 |
中国医学 | 6篇 |
肿瘤学 | 64篇 |
出版年
2023年 | 7篇 |
2022年 | 13篇 |
2021年 | 26篇 |
2020年 | 13篇 |
2019年 | 26篇 |
2018年 | 26篇 |
2017年 | 22篇 |
2016年 | 22篇 |
2015年 | 18篇 |
2014年 | 29篇 |
2013年 | 37篇 |
2012年 | 79篇 |
2011年 | 69篇 |
2010年 | 50篇 |
2009年 | 62篇 |
2008年 | 86篇 |
2007年 | 67篇 |
2006年 | 47篇 |
2005年 | 42篇 |
2004年 | 42篇 |
2003年 | 40篇 |
2002年 | 35篇 |
2001年 | 16篇 |
2000年 | 12篇 |
1999年 | 25篇 |
1998年 | 12篇 |
1997年 | 10篇 |
1996年 | 7篇 |
1995年 | 3篇 |
1994年 | 10篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 3篇 |
1990年 | 6篇 |
1989年 | 4篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 5篇 |
1985年 | 3篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 6篇 |
1976年 | 2篇 |
1975年 | 4篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1968年 | 2篇 |
排序方式: 共有1034条查询结果,搜索用时 0 毫秒
1.
2.
K C Gopalakrishnan J Lewis 《The Journal of bone and joint surgery. British volume》1990,72(4):554-556
We report seven children in whom traumatic haemarthrosis of the hip had produced lateral subluxation of the femoral head, which is different from the apparent displacement seen in Perthes' disease. In all seven cases, aspiration of the haemarthrosis allowed reduction of the femoral head, and follow-up for a mean of 14 months revealed no evidence of avascular necrosis of the proximal femoral epiphysis. Traumatic haemarthrosis of the hip in children appears to be a clinical entity which can produce femoral head subluxation. Aspiration and traction is the treatment of choice and can cure the condition. 相似文献
3.
Calcium antagonizes the magnesium-induced high affinity state of the hepatic vasopressin receptor for the agonist interaction.
下载免费PDF全文
![点击此处可从《British journal of pharmacology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
H. Wang V. Gopalakrishnan J. R. McNeill P. V. Sulakhe C. R. Triggle 《British journal of pharmacology》1990,100(1):5-10
1. The present study describes the role of Ca2+ in the regulation of the hepatic vasopressin V1 receptor. With low concentrations of Ca2+, there was a small increase in [3H]-arginine vasopressin [( 3H]-AVP) binding, but above 10 mM, Ca2+ decreased the binding of this agonist. In contrast, low concentrations of Mg2+ were associated with a dramatic concentration-dependent increase in [3H]-AVP binding, reaching a maximal effect of 650% above control at concentrations ranging between 1-5 mM. At higher concentrations of Mg2+, the stimulatory effect of this cation was less pronounced, falling to 210% of control at 100 mM Mg2+. Strikingly, Ca2(+)-inhibited the stimulatory effect of Mg2+ in a concentration-dependent fashion. 2. Saturation binding data revealed that Ca2+ (2 to 10 mM) per se promotes the high affinity conformation of the V1 receptor for the agonist binding with the KD decreased from a control value of 2.3 nM to 0.5 nM in the presence of 10 mM Ca2+. This effect was attenuated with an increase in Ca2+ above 10 mM. With an increase in Ca2+ to 20 mM, however, the Bmax for [3H]-AVP binding was decreased. Ca2+ also decreased the high affinity/high capacity state (KD 100 pM) of the receptor induced by 1 mM Mg2+ for agonist interaction. 3. [3H]-V1 antagonist binding was inhibited by both Ca2+ and Mg2+. The IC50 values (mean +/- s.e. mean) for Ca2+ and Mg2+ were 32 +/- 8 and 53 +/- 9 mM respectively. Maximal inhibition achieved at 100 mM was 29% for Ca2+ and 42% for Mg2+.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
4.
Sunil Kumar Saxena S. Gopalakrishnan 《Indian journal of otolaryngology and head and neck surgery》2003,55(4):281-282
Despite the common occurrence of pleomorphic adenoma of major salivary glands, intranasal pleomorphic adenoma are rare. We
present a ease of pleomorphic adenoma of the nasal septum along with a brief review of literature. The histological nature
of this lesion in comparison to other salivary gland tumours and the importance of an accurate diagnosis has been stressed. 相似文献
5.
Conversion of myoblasts to physiologically active neuronal phenotype 总被引:13,自引:0,他引:13
Watanabe Y Kameoka S Gopalakrishnan V Aldape KD Pan ZZ Lang FF Majumder S 《Genes & development》2004,18(8):889-900
6.
Renal transplant (RT) is now a therapy of choice for end stage renal disease (ESRD). The Nephrology Unit, Asvini started functioning in Dec 90 and to date 1298 sittings of hemodialysis have been given to 45 patients. Of these, 35 were in ESRD and 11 patients underwent renal transplantation at this hospital during the period Jan 91 – Dec 93. One patient expired after 18 months of transplantation due to infection. Early experience in screening patients for RT, use of immunosuppression, management of rejection episodes and protocol are presented with special emphasis on its relevance to the Armed Forces.KEY WORDS: Transplantation, Renal Failure, Immunosuppression, Rejection 相似文献
7.
Serving personnel of Armed Forces admitted with tuberculosis between Apr 1996–1999 were evaluated for co-infection of tuberculosis and HIV. Sixty (1.06%) of tuberculosis patients were found to be HIV positive. Initial test was done by spot kits and subsequently confirmed by ELISA on two different samples. Majority of the cases were in sexually active age group 48 (80%). Alcohol and smoking was associated in 80% cases. Thirty six (60%) were sputum smear positive for AFB. Twenty eight (46.7%) gave history of exposure to sex workers. Family members were not available for study. Sero prevalence of HIV in association with tuberculosis is less in Armed Forces compared to civil population.KEY WORDS: HIV, Seroprevalence, Tuberculosis 相似文献
8.
Jayaprakasam Bolleddula Sathej Gopalakrishnan Ping Hu Jennifer Dong Karthik Venkatakrishnan 《CTS Clinical and Translational Science》2022,15(9):2075
N‐Nitrosamine (NA) impurities are considered genotoxic and have gained attention due to the recall of several marketed drug products associated with higher‐than‐permitted limits of these impurities. Rifampicin is an index inducer of multiple cytochrome P450s (CYPs) including CYP2B6, 2C8, 2C9, 2C19, and 3A4/5 and an inhibitor of OATP1B transporters (single dose). Hence, rifampicin is used extensively in clinical studies to assess drug–drug interactions (DDIs). Despite NA impurities being reported in rifampicin and rifapentine above the acceptable limits, these critical anti‐infective drugs are available for therapeutic use considering their benefit–risk profile. Reports of NA impurities in rifampicin products have created uncertainty around using rifampicin in clinical DDI studies, especially in healthy volunteers. Hence, a systematic investigation through a literature search was performed to determine possible alternative index inducer(s) to rifampicin. The available strong CYP3A inducers were selected from the University of Washington DDI Database and their in vivo DDI potential assessed using the data from clinical DDI studies with sensitive CYP3A substrates. To propose potential alternative CYP3A inducers, factors including lack of genotoxic potential, adequate safety, feasibility of multiple dose administration to healthy volunteers, and robust in vivo evidence of induction of CYP3A were considered. Based on the qualifying criteria, carbamazepine, phenytoin, and lumacaftor were identified to be the most promising alternatives to rifampicin for conducting CYP3A induction DDI studies. Strengths and limitations of the proposed alternative CYP3A inducers, the magnitude of in vivo CYP3A induction, appropriate study designs for each alternative inducer, and future perspectives are presented in this paper. 相似文献
9.
Murugu Sundara Pandiyan Periasamy Sivakumar Poongavanam Andappan Gopalakrishnan Vedamoorthy 《Indian Journal of Thoracic and Cardiovascular Surgery》2013,29(1):29-31
Tracheoesophageal fistula after blunt trauma is very rare. Typically the patient is a young male driving a car and is thrust onto the steering wheel following sudden deceleration as in a high speed road traffic accident. In our case that victim is a motorcyclist who fell down on his right side and developed such a fistula after 3 days. We report the clinical summary and a brief review of literature. 相似文献
10.
Srinivas BK Gopalakrishnan M Mahadevan R Satyaprasad V 《Asian cardiovascular & thoracic annals》2002,10(1):64-65
A 36-year-old female was admitted with dyspnea on exertion of one year's duration. Echocardiography revealed a tumor arising from interventricular septum with dynamic left ventricular outflow tract obstruction. On cardiopulmonary bypass with cardioplegic arrest, the tumor was approached through a transverse aortotomy, and excised from the interventricular septum through the aortic valve. Postoperative recovery was uneventful and the patient was asymptomatic with no recurrence at follow-up after one year. 相似文献