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排序方式: 共有143条查询结果,搜索用时 218 毫秒
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肿瘤相关基因Cap43在胰腺癌中的表达及意义 总被引:4,自引:0,他引:4
目的研究肿瘤相关基因Cap43在胰腺癌组织中的表达情况,探讨其对胰腺癌的诊断价值。方法收集1999年4月~2002年8月长海医院外科手术切除胰腺癌标本和癌旁正常组织33例,诊断均由病理证实。男性22例,女性11例,年龄30~73岁,平均58.1岁。所有组织标本按肿瘤、癌旁(正常)配对。采用RT-PCR和Northern杂交方法研究Cap43 mRNA表达情况。结果 RT-PCR结果显示,Cap43在肿瘤组织中表达显著上调,其在肿瘤组织和癌旁正常组织的扫描值分别为4 033±1 986和2 244±1 145,有显著差异(P<0.001)。Northern杂交亦显示Cap43在肿瘤组织中表达显著上调,相同病例的RT-PCR结果与Northern杂交的结果有较好的一致性,经回归分析,没有显著性差异(P>0.1)。结论 Cap43在胰腺癌组织中呈显著高表达,其有可能成为胰腺癌早期诊断的重要标志物。 相似文献
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Avinash Bhakta Owen Glotzer Ashar Ata Marcel Tafen Steven C. Stain Paul T. Singh 《American journal of surgery》2018,215(4):643-646
Background
Postoperative pain management is a major contributor to recovery and discharge in bariatric surgery. Local anesthetic agents are of particular interest: they're non-sedating and may reduce postoperative pain and hospital length of stay (LOS).Design
Researchers queried the Bariatric Surgery Service Database for patients undergoing laparoscopic weight loss surgery from January 2012–December 2014. Patients were divided between those who did and did not receive liposomal bupivacaine intra-operatively. Measures included demographics, narcotic use, LOS, antiemetic use, and pain scales.Results
The liposomal group consisted of 233 patients and the PCA group consisted of 243 patients. The liposomal group had significantly less narcotic use than the PCA group in terms of IV morphine equivalents. This did not translate into a reduction in LOS in the liposomal group.Conclusions
TAP block using liposomal bupivacaine provides effective analgesia comparable to PCA. 相似文献7.
N Marsden AP Saklani M Davies TV Chandrasekaran U Khot J Beynon 《Annals of the Royal College of Surgeons of England》2009,91(8):W7-W8
Intussusception in adults is a rare cause of abdominal pain. Unlike its paediatric counterpart, intussusception in adults is associated with obvious pathology. We describe a case of ileocolic intussusception extending to the splenic flexure. We were able to reduce the intussusception partially and pedicle was stapled carefully. The specimen was delivered through a small incision and right hemicolectomy was performed adhering to oncological principles. We recommend laparoscopic-assisted surgery is considered for adult intussusceptions. 相似文献
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Chen T Zhang Z Glotzer SC 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(3):717-722
Molecular simulations of the self-assembly of cone-shaped particles with specific, attractive interactions are performed. Upon cooling from random initial conditions, we find that the cones self-assemble into clusters and that clusters comprised of particular numbers of cones (e.g., 4-17, 20, 27, 32, and 42) have a unique and precisely packed structure that is robust over a range of cone angles. These precise clusters form a sequence of structures at specific cluster sizes (a "precise packing sequence") that for small sizes is identical to that observed in evaporation-driven assembly of colloidal spheres. We further show that this sequence is reproduced and extended in simulations of two simple models of spheres self-assembling from random initial conditions subject to convexity constraints, including an initial spherical convexity constraint for moderate- and large-sized clusters. This sequence contains six of the most common virus capsid structures obtained in vivo, including large chiral clusters and a cluster that may correspond to several non-icosahedral, spherical virus capsids obtained in vivo. Our findings suggest that this precise packing sequence results from free energy minimization subject to convexity constraints and is applicable to a broad range of assembly processes. 相似文献
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JH Raphael JL Southall TV Gnanadurai GJ Treharne GD Kitas 《BMC musculoskeletal disorders》2002,3(1):17-8
Background
Continuous intrathecal drug delivery has been shown in open studies to improve pain and quality of life in those with intractable back pain who have had spinal surgery. There is limited data on long term effects and and even less for patients with mechanical back pain without prior spinal surgery. 相似文献10.
Taya V. Glotzer Emile G. Daoud D. George Wyse Daniel E. Singer Reece Holbrook Khadeeja Pruett Kenneth Smith Christopher E. Hilker 《Journal of interventional cardiac electrophysiology》2006,15(1):9-14
Background: Sustained atrial fibrillation (AF) is a common risk factor for stroke. While intermittent AF also appears to pose a substantial
stroke risk, the quantitative relationship between the percentage of time spent in AF and stroke risk is poorly specified
and “intermittent” AF is not the same as paroxysmal AF. Improved assessment of the impact of AF burden on stroke risk will
allow more targeted and safer use of antithrombotic therapy.
Methods and Results: The primary objective of this study is to determine if AT/AF (all device detected atrial tachyarrhythmias, including atrial
flutter, atrial fibrillation, and atrial tachycardia) burden over a 30 day period is an independent predictor of the occurrence
of ischemic stroke, transient ischemic attack (TIA) and/or systemic embolism in subjects not receiving anticoagulation therapy.
TRENDS is a prospective, post-market, non-randomized, multicenter study designed to enroll 3100 subjects who have an independent
Class I/II indication for cardiac rhythm device implantation and who have demographic features suggestive of an increased
risk for thromboembolic complications related to AT/AF. All implanted devices will have the ability to collect long-term AT/AF
burden trending data and will be equivalently programmed to ensure consistent data collection. All subjects will be followed
with device interrogations every 3 months and clinic visits every 6 months for 1 year. Subjects with a documented history
of AT/AF prior to enrollment and those who develop AT/AF during the 12-month follow-up will be followed until the last subject
enrolled in the study has completed their 24-month follow-up.
Conclusions: The results of the TRENDS study should help clarify the implications of data retrieved from an implantable device with regard
to the risk for thromboembolic complications from atrial arrhythmias, even in the absence of symptoms. 相似文献