全文获取类型
收费全文 | 2146篇 |
免费 | 133篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 158篇 |
妇产科学 | 13篇 |
基础医学 | 246篇 |
口腔科学 | 79篇 |
临床医学 | 161篇 |
内科学 | 516篇 |
皮肤病学 | 40篇 |
神经病学 | 113篇 |
特种医学 | 80篇 |
外科学 | 332篇 |
综合类 | 36篇 |
预防医学 | 60篇 |
眼科学 | 36篇 |
药学 | 176篇 |
中国医学 | 10篇 |
肿瘤学 | 213篇 |
出版年
2023年 | 20篇 |
2022年 | 33篇 |
2021年 | 70篇 |
2020年 | 42篇 |
2019年 | 69篇 |
2018年 | 70篇 |
2017年 | 60篇 |
2016年 | 69篇 |
2015年 | 66篇 |
2014年 | 87篇 |
2013年 | 118篇 |
2012年 | 186篇 |
2011年 | 183篇 |
2010年 | 90篇 |
2009年 | 81篇 |
2008年 | 146篇 |
2007年 | 134篇 |
2006年 | 131篇 |
2005年 | 108篇 |
2004年 | 106篇 |
2003年 | 67篇 |
2002年 | 60篇 |
2001年 | 32篇 |
2000年 | 32篇 |
1999年 | 30篇 |
1998年 | 16篇 |
1997年 | 8篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 6篇 |
1992年 | 10篇 |
1991年 | 16篇 |
1990年 | 12篇 |
1989年 | 12篇 |
1988年 | 18篇 |
1987年 | 6篇 |
1986年 | 11篇 |
1985年 | 8篇 |
1984年 | 8篇 |
1983年 | 3篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 7篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1973年 | 2篇 |
1968年 | 4篇 |
1967年 | 4篇 |
1966年 | 4篇 |
排序方式: 共有2294条查询结果,搜索用时 793 毫秒
1.
2.
Lesley A. Inker Morgan E. Grams Andrew S. Levey Josef Coresh Massimo Cirillo John F. Collins Ron T. Gansevoort Orlando M. Gutierrez Takayuki Hamano Gunnar H. Heine Shizukiyo Ishikawa Sun Ha Jee Florian Kronenberg Martin J. Landray Katsuyuki Miura Girish N. Nadkarni Carmen A. Peralta Dietrich Rothenbacher Mark Woodward 《American journal of kidney diseases》2019,73(2):206-217
3.
Clinical Rheumatology - Our aim was to determine reasons for admission, the prevalence and spectrum of infections, and the outcomes in a multiethnic cohort of hospitalized systemic lupus... 相似文献
4.
The clinical relevance of t(14; 18)/BCL-2 rearrangement and DEL 6q in diffuse large cell lymphoma and immunoblastic lymphoma 总被引:1,自引:0,他引:1
Background: t(14; 18)/bcl-2 gene rearrangement (R) is claimedto impart a worse rate of complete remission and disease-freesurvival in diffuse large cell lymphoma (DLCL). DEL 6q has alsobeen associated with poor outcome. Design: Retrospective studyof 54 patients with either diffuse large cell or immunoblasticlymphoma who had cytogenetics and/or molecular studies performed.Results: Patient characteristics, complete remission rate, andtime to treatment failure (TTF) were similar at three year follow-upfor groups with and without t(14; 18)/BCL-2R Survival was worsefor the former but the difference was not statistically significant.For DEL 6q, patient characteristics and survival rates weresimilar at three year follow-up for patients with and withoutthe abnormality. TTF was worse for the former but this was notstatistically significant. Conclusion: This study, with equalor greater number of patients with t(14; 18) than previous reports,fails to show a worse prognosis for patients with the t(14;18) chromosomal abnormality. A definite association will awaitfurther accrual of patients and a meaningul multivariate analysis. lymphoma, BCL-2, cytogenetics, DEL 6q 相似文献
5.
We report our experience of eight cases of isolated full thickness burns of the penis. Early excision of burns of the penile shaft and repair with a preputial flap or mesh split skin graft produces excellent results, with a reduction in complications and an early re-establishment of sexual function. Conservative treatment of burns of the glans, on the other hand, is appropriate and results in minimal scarring. 相似文献
6.
Measurement of cerebral monoamine oxidase B activity using L-[11C]deprenyl and dynamic positron emission tomography 总被引:3,自引:0,他引:3
A A Lammertsma C J Bench G W Price J E Cremer S K Luthra D Turton N D Wood R S Frackowiak 《Journal of cerebral blood flow and metabolism》1991,11(4):545-556
A tracer kinetic procedure was developed for the measurement of monoamine oxidase type B (MAO-B) activity using L-[11C]deprenyl and positron emission tomography (PET). The kinetic model consisted of two tissue compartments with irreversible binding to the second compartment (three rate constants). In addition, a blood volume component was included. Special attention was given to the accurate measurement of the plasma and whole blood input functions. The method was applied to the measurement of the dose-response curve of a reversible MAO-B inhibitor (Ro 19-6327). From the results, it followed that the rate constant for irreversible binding (k3) appeared to be a better index of MAO-B activity than the net influx constant Ki. Furthermore, regional analysis demonstrated that Ki, but not k3, was flow dependent. This implies that full kinetic analysis is required for an accurate assessment of MAO-B activity. 相似文献
7.
Girish S. Mishra Arpan Bhatia 《Indian journal of otolaryngology and head and neck surgery》2007,59(3):296-297
Dermatofibrosarcoma protuberance of head and neck is a rare neoplasm and accounts for less than one percent of Head and Neck Neoplasm. The objective of this report is to understand etiology, presentation, histopathologic identification and treatment option for this tumour. The goal of current report is to acquaint the clinician with presentation and treatment option for this disease. 相似文献
8.
D J Brooks J S Gibbs P Sharp S Herold D R Turton S K Luthra E M Kohner S R Bloom T Jones 《Journal of cerebral blood flow and metabolism》1986,6(2):240-244
Regional cerebral [11C]3-O-methyl-D-glucose ([11C]MeG) uptake kinetics have been measured in five insulin-dependent diabetic patients and four normal controls using positron emission tomography (PET). Concomitant measurement of regional cerebral blood volume and CBF enabled corrections for the presence of intravascular [11C]MeG signal in cerebral regions of interest to be carried out, and regional cerebral [11C]MeG unidirectional extraction fractions to be computed. Four of the five diabetic subjects were studied with their fasting plasma glucose level clamped at a normoglycaemic level (4 mM), and four were studied at hyperglycaemic plasma glucose levels (mean 13 mM). The four diabetic subjects whose fasting plasma glucose levels were clamped at a normoglycaemic level of 4 mM had mean fasting whole-brain, cortical, and white matter [11C]MeG extraction fractions of 15, 15, and 16%, respectively, values similar to those found for the four normal controls (whole brain, 14%; cortex, 13%; white matter, 17%). Mean regional cerebral [11C]MeG extraction fractions were significantly reduced in diabetic subjects during hyperglycaemia whether their plasma insulin levels were undetectable or whether they were raised by continuous intravenous insulin infusion. Such a reduction in [11C]MeG extraction under hyperglycaemic conditions can be explained entirely in terms of increased competition between [11C]MeG and D-glucose for the passive facilitated transport carrier system for hexoses across the blood-brain barrier (BBB). It is concluded that the number and affinity of D-glucose carriers present in the BBB are within normal limits in treated insulin-dependent diabetic subjects. In addition, insulin appears to have no effect on the transport of D-glucose across the BBB. 相似文献
9.
10.
Weiss Robert A. MD McDaniel David H. MD † Geronemus Roy G. MD ‡ MARGARET A. WEISS MD KAREN L. BEASLEY MD § Munavalli Girish M. MD§ § Bellew Supriya G. MD ¶ 《Dermatologic surgery》2005,31(S3):1199-1205
Background. Light-emitting diode (LED) photomodulation is a novel nonthermal technology used to modulate cellular activity with light.
Objective:. We describe our experience over the last 2 years using 590 nm LED photomodulation within a dermatologic surgery environment.
Methods. Practical use of nonthermal light energy and emerging applications in 3,500 treatments delivered to 900 patients is detailed.
Results. LED photomodulation has been used alone for skin rejuvenation in over 300 patients but has been effective in augmentation of results in 600 patients receiving concomitant nonablative thermal and vascular treatments such as intense pulsed light, pulsed dye laser, KTP and infrared lasers, radiofrequency energy, and ablative lasers.
Conclusion:. LED photomodulation reverses signs of photoaging using a new nonthermal mechanism. The anti-inflammatory component of LED in combination with the cell regulatory component helps improve the outcome of other thermal-based rejuvenation treatments. 相似文献
Objective:. We describe our experience over the last 2 years using 590 nm LED photomodulation within a dermatologic surgery environment.
Methods. Practical use of nonthermal light energy and emerging applications in 3,500 treatments delivered to 900 patients is detailed.
Results. LED photomodulation has been used alone for skin rejuvenation in over 300 patients but has been effective in augmentation of results in 600 patients receiving concomitant nonablative thermal and vascular treatments such as intense pulsed light, pulsed dye laser, KTP and infrared lasers, radiofrequency energy, and ablative lasers.
Conclusion:. LED photomodulation reverses signs of photoaging using a new nonthermal mechanism. The anti-inflammatory component of LED in combination with the cell regulatory component helps improve the outcome of other thermal-based rejuvenation treatments. 相似文献