全文获取类型
收费全文 | 35235篇 |
免费 | 1796篇 |
国内免费 | 350篇 |
专业分类
耳鼻咽喉 | 335篇 |
儿科学 | 740篇 |
妇产科学 | 1031篇 |
基础医学 | 4203篇 |
口腔科学 | 845篇 |
临床医学 | 2539篇 |
内科学 | 9616篇 |
皮肤病学 | 586篇 |
神经病学 | 3631篇 |
特种医学 | 1411篇 |
外科学 | 5475篇 |
综合类 | 80篇 |
一般理论 | 5篇 |
预防医学 | 1346篇 |
眼科学 | 426篇 |
药学 | 1963篇 |
中国医学 | 69篇 |
肿瘤学 | 3080篇 |
出版年
2024年 | 24篇 |
2023年 | 236篇 |
2022年 | 462篇 |
2021年 | 1071篇 |
2020年 | 622篇 |
2019年 | 783篇 |
2018年 | 1028篇 |
2017年 | 804篇 |
2016年 | 922篇 |
2015年 | 1030篇 |
2014年 | 1428篇 |
2013年 | 1745篇 |
2012年 | 2637篇 |
2011年 | 2682篇 |
2010年 | 1600篇 |
2009年 | 1513篇 |
2008年 | 2519篇 |
2007年 | 2498篇 |
2006年 | 2270篇 |
2005年 | 2232篇 |
2004年 | 2098篇 |
2003年 | 1911篇 |
2002年 | 1693篇 |
2001年 | 223篇 |
2000年 | 187篇 |
1999年 | 256篇 |
1998年 | 319篇 |
1997年 | 268篇 |
1996年 | 274篇 |
1995年 | 202篇 |
1994年 | 177篇 |
1993年 | 164篇 |
1992年 | 156篇 |
1991年 | 122篇 |
1990年 | 114篇 |
1989年 | 115篇 |
1988年 | 79篇 |
1987年 | 82篇 |
1986年 | 84篇 |
1985年 | 66篇 |
1984年 | 85篇 |
1983年 | 70篇 |
1982年 | 62篇 |
1981年 | 75篇 |
1980年 | 71篇 |
1979年 | 37篇 |
1978年 | 18篇 |
1977年 | 27篇 |
1976年 | 23篇 |
1974年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Julie Despres Yasmina Ramdani Marine di Giovanni Magalie Bnard Abderrakib Zahid Mait Montero‐Hadjadje Florent Yvergnaux Thibaut Saguet Azeddine Driouich Marie‐Laure Follet‐Gueye 《Experimental dermatology》2019,28(8):922-932
It is well recognized that the world population is ageing rapidly. Therefore, it is important to understand ageing processes at the cellular and molecular levels to predict the onset of age‐related diseases and prevent them. Recent research has focused on the identification of ageing biomarkers, including those associated with the properties of the Golgi apparatus. In this context, Golgi‐mediated glycosylation of proteins has been well characterized. Additionally, other studies show that the secretion of many compounds, including pro‐inflammatory cytokines and extracellular matrix–degrading enzymes, is modified during ageing, resulting in physical and functional skin degradation. Since the Golgi apparatus is a central organelle of the secretory pathway, we investigated its structural organization in senescent primary human dermal fibroblasts using confocal and electron microscopy. In addition, we monitored the expression of Golgi‐related genes in the same cells. Our data showed a marked alteration in the Golgi morphology during replicative senescence. In contrast to its small and compact structure in non‐senescent cells, the Golgi apparatus exhibited a large and expanded morphology in senescent fibroblasts. Our data also demonstrated that the expression of many genes related to Golgi structural integrity and function was significantly modified in senescent cells, suggesting a relationship between Golgi apparatus function and ageing. 相似文献
2.
3.
Angela Mauro Salvatore Mauro Roberto Rega Luigi Martemucci Rita Sottile 《Pediatric dermatology》2019,36(1):e34-e36
Henoch‐Schonlein purpura (HSP) is the most common systemic vasculitis in childhood. There is no consensus about the management for isolated cutaneous manifestations in HSP. We describe a case of HSP presenting with severe skin lesions that did not respond to standard therapy with corticosteroids. The 11‐year‐old child was treated with intravenous immunoglobulins, which induced rapid and persistent resolution of symptomatology. 相似文献
4.
5.
6.
7.
Anna Maria Colangelo Giovanni Cirillo Lilia Alberghina Michele Papa Hans V.Westerhoff 《中国神经再生研究》2019,(2)
The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology. 相似文献
8.
9.
10.
Michael M Gezalian Luigi Mangiacotti Padmesh Rajput Nicklaus Sparrow Konrad Schlick Shouri Lahiri 《Journal of cerebral blood flow and metabolism》2021,41(4):693
Adrenoceptor and calcium channel modulating medications are widely used in clinical practice for acute neurological and systemic conditions. It is generally assumed that the cerebrovascular effects of these drugs mirror that of their systemic effects – and this is reflected in how these medications are currently used in clinical practice. However, recent research suggests that there are distinct cerebrovascular-specific effects of these medications that are related to the unique characteristics of the cerebrovascular anatomy including the regional heterogeneity in density and distribution of adrenoceptor subtypes and calcium channels along the cerebrovasculature. In this review, we critically evaluate existing basic science and clinical research to discuss known and putative interactions between adrenoceptor and calcium channel modulating pharmacotherapies, the neurovascular unit, and cerebrovascular anatomy. In doing so, we provide a rationale for selecting vasoactive medications based on lesion location and lay a foundation for future investigations that will define neuroprotective paradigms of adrenoceptor and calcium channel modulating therapies to improve neurological outcomes in acute neurological and systemic disorders. 相似文献