全文获取类型
收费全文 | 608篇 |
免费 | 36篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 2篇 |
妇产科学 | 6篇 |
基础医学 | 121篇 |
口腔科学 | 17篇 |
临床医学 | 50篇 |
内科学 | 149篇 |
皮肤病学 | 10篇 |
神经病学 | 103篇 |
特种医学 | 17篇 |
外科学 | 47篇 |
综合类 | 2篇 |
预防医学 | 12篇 |
药学 | 87篇 |
中国医学 | 3篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 5篇 |
2022年 | 16篇 |
2021年 | 19篇 |
2020年 | 10篇 |
2019年 | 14篇 |
2018年 | 16篇 |
2017年 | 16篇 |
2016年 | 11篇 |
2015年 | 17篇 |
2014年 | 17篇 |
2013年 | 18篇 |
2012年 | 34篇 |
2011年 | 46篇 |
2010年 | 14篇 |
2009年 | 14篇 |
2008年 | 30篇 |
2007年 | 41篇 |
2006年 | 30篇 |
2005年 | 33篇 |
2004年 | 34篇 |
2003年 | 42篇 |
2002年 | 39篇 |
2001年 | 12篇 |
2000年 | 16篇 |
1999年 | 14篇 |
1998年 | 12篇 |
1997年 | 14篇 |
1996年 | 9篇 |
1995年 | 5篇 |
1994年 | 9篇 |
1993年 | 5篇 |
1992年 | 7篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1978年 | 1篇 |
1937年 | 1篇 |
1915年 | 1篇 |
1914年 | 1篇 |
排序方式: 共有650条查询结果,搜索用时 15 毫秒
1.
Megakaryocytic Progenitors Can Be Generated Ex Vivo and Safely Administered to Autologous Peripheral Blood Progenitor Cell Transplant Recipients 总被引:9,自引:1,他引:8
2.
3.
Torti C Quiros-Roldan E Monno L Patroni A Saracino A Angarano G Tinelli C Lo Caputo S Tirelli V Mazzotta F Carosi G;MASTER Cohort GenPheRex Study Group;MASTER Cohort PhenGen Study Group 《Journal of medical virology》2004,74(1):29-33
This study aimed at identifying HIV-1 protease amino acid changes associated with protease inhibitor (PI) exposure and susceptibility. New amino acid substitutions were correlated with the number of experienced PIs, reaching statistical significance only for those at positions 3, 44, and 74. The correspondence multivariate model demonstrated that > or =3 experienced PIs and substitutions or mutations at positions 3, 46, 54, 73, 74, and 84 were correlated with PI cross-resistance, including resistance for lopinavir and amprenavir in this cohort of patients who were naive for these drugs. 相似文献
4.
Scotto G Saracino A El-Hamed I Iannece MD Geraci S Palumbo E Cibelli DC Angarano G 《Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive》2004,12(4):245-251
In order to retrospectively evaluate the prevalence of immigrant patients affected by active tuberculosis, we analysed the clinical data of 2255 immigrant patients hospitalised during 2002 in ordinary admission or in Day Hospital in 48 Clinics of Infectious Diseases. In all, 303 patients were affected by active tuberculosis (13.4% of the total immigrant hospitalised patients); 30 patients (9.9%) were also HIV-positive. There was a considerable male gender bias (62.5%); the mean age was 29.7 years; 144 patients were from Africa (47.5%), 72 (23.7%) from Asia, 47 (15.5%) from eastern Europe and 40 (13.2%) from South America. The clinical variants were: pulmonary (57.7%), lymph node (15.8%), meningitis (13.8%), intestinal (4.2%), bone (3.3%), pleurical (2.3%), peritoneal (2.3%) and renal (0.6%). We conclude that tuberculosis is a very frequent disease among immigrants, especially of African origin. The high percentage is due to several factors, such as no vaccine prophylaxis and poor, overcrowded living conditions. It is fundamental to focus on the need to provide better health support for all subjects by setting up screening plans to estimate the real incidence of this pathology and ensure medical treatment to prevent the spread of this infection among immigrants and the local host population. 相似文献
5.
IL-10, an inflammatory/inhibitory cytokine,but not always 总被引:24,自引:0,他引:24
6.
Mancuso M Conforti FL Rocchi A Tessitore A Muglia M Tedeschi G Panza D Monsurrò M Sola P Mandrioli J Choub A DelCorona A Manca ML Mazzei R Sprovieri T Filosto M Salviati A Valentino P Bono F Caracciolo M Simone IL La Bella V Majorana G Siciliano G Murri L Quattrone A 《Neuroscience letters》2004,371(2-3):158-162
Mitochondrial impairment has been implicated in the pathogenesis of the amyotrophic lateral sclerosis (ALS). Furthermore, mitochondrial-specific polymorphisms were previously related to other neurodegenerative diseases, such as Parkinson, Friedreich and Alzheimer disease. To investigate if specific genetic polymorphisms within the mitochondrial genome (mtDNA) could act as susceptibility factors and contribute to the clinical expression of sporadic ALS (sALS), we have genotyped predefined European mtDNA haplogroups in 222 Italian patients with sALS and 151 matched controls. Individuals classified as haplogroup I demonstrated a significant decrease in risk of ALS versus individuals carrying the most common haplogroup, H (odds ratio 0.08, 95% confidence interval 0.04-0.4, p < 0.01). Further stratification of the dataset by sex, age and site of onset of disease and survival failed to reach significance for association. Our study provides evidence of the contribution of mitochondrial variation to the risk of ALS development in Caucasians. Further it may help elucidate the mechanism of the mitochondrial dysfunction detectable in ALS, and may be of relevance in development of strategies for the treatment of this disease. 相似文献
7.
8.
Marcello Moccia Francesco Brigo Gioacchino Tedeschi Simona Bonavita Luigi Lavorgna 《Neurological sciences》2018,39(6):981-987
Nowadays, the Internet is the major source to obtain information about diseases and their treatments. The Internet is gaining relevance in the neurological setting, considering the possibility of timely social interaction, contributing to general public awareness on otherwise less-well-known neurological conditions, promoting health equity and improving the health-related coping. Neurological patients can easily find several online opportunities for peer interactions and learning. On the other hand, neurologist can analyze user-generated data to better understand patient needs and to run epidemiological studies. Indeed, analyses of queries from Internet search engines on certain neurological diseases have shown a strict temporal and spatial correlation with the “real world.” In this narrative review, we will discuss how the Internet is radically affecting the healthcare of people with neurological disorders and, most importantly, is shifting the paradigm of care from the hands of those who deliver care, into the hands of those who receive it. Besides, we will review possible limitations, such as safety concerns, financial issues, and the need for easy-to-access platforms. 相似文献
9.
Valeria Navach Luca Salvatore Calabrese Valeria Zurlo Daniela Alterio Luigi Funicelli Gioacchino Giugliano 《Dysphagia》2011,26(2):196-199
Lipofilling is a well-established technique in reconstructive plastic surgery. It is used primarily in recontouring of the
body and face to correct post-traumatic and congenital defects. The regenerative properties of adipose tissue have allowed
the use of the lipofilling technique for the treatment of burn sequelae and irradiated breast to improve tissue quality and
elasticity. We report on the case of a patient treated with radiation therapy for a nasopharyngeal carcinoma who presented
with severe postradiation dysphagia. The lipofilling technique was successfully used to improve abnormal swallowing. The technical
details and functional outcomes are discussed. 相似文献
10.
Paola L. Minciullo Gioacchino Calapai Sebastiano Gangemi 《Allergy, asthma & immunology research》2014,6(5):467-469
Glatiramer acetate (GA) is a synthetic amino acid polymer, used for relapsing-remitting multiple sclerosis. The most common adverse effect of GA is a skin reaction at the injection site with a probable IgE-mediated mechanism. We report a case of a 45-year-old woman with multiple sclerosis and urticaria to interferon-β1a, who underwent a challenge test to GA. She presented itching wheals at the intradermal sites. A month later the patient repeated the test and presented the same reactions of the first test. The next day she continued the test with subcutaneous injections. One hour later she presented a flare up of the reactions appeared during the previous 2 tests. No reactions appeared at the subcutaneous injection sites. The patient also presented dyspnea. Flare-up reactions are characterized by the reactivation of previously positive reactions to intradermal or skin tests triggered by patch testing and after systemic provocation with an allergen. The phenomenon is not common to drugs. The mechanisms involved in this reaction seem to be heterogeneous and are not completely understood. To our knowledge this is the first case of allergic reaction to GA manifested as a flare-up reaction during challenge test. 相似文献