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Thirty-six male cocaine abusers, in withdrawal, were studied for 99 days in a double-blind design. Treatment with bromocriptine was significantly more effective than placebo in alleviating withdrawal symptoms. Adding desipramine to the bromocriptine regimen was significantly more effective than either placebo or bromocriptine alone. The authors hypothesize that these results support a model of dopamine depletion and receptor supersensitivity in cocaine withdrawal. 相似文献
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Sequential contrast-enhanced MR imaging of the penis 总被引:1,自引:0,他引:1
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G Canton L Giannini G Magni A Bertinaria M Cibin L Gallimberti 《Acta psychiatrica Scandinavica》1988,78(1):18-23
We investigated the relationship of locus of control and life events to outcome of treatment at 6 months in 67 patients with alcohol dependence. Outcome was less favourable in patients with pre-treatment scores indicating external locus of control than in those with internal locus of control. Furthermore, patients with relapse in the follow-up period experienced more independent life events with moderate to severe objective negative impact than those with more favourable outcome. These results suggest that locus of control may be of clinical use in formulating treatment and prognosis, and that the occurrence of life events may influence outcome. The results are discussed in relation to strategies for treatment and prevention of relapse. 相似文献
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Amyloid fibril formation by human stefin B: influence of pH and TFE on fibril growth and morphology.
Eva Zerovnik Miha Skarabot Katja Skerget Silva Giannini Veronika Stoka Sasa Jenko-Kokalj Rosemary A Staniforth 《Amyloid》2007,14(3):237-247
As shown before, human stefin B (cystatin B) populates two partly unfolded species, a native-like state at pH 4.8 and a structured molten globule state at pH 3.3 (high ionic strength), from each of which amyloid fibrils grow. Here, we show that the fibrils obtained at pH 3.3 differ from those at pH 4.8 and that those obtained at pH 3.3 (protofibrils) do not transform readily to mature fibrils. In addition we show that amorphous aggregates are also a source of fibrils. The kinetics of amyloid fibril formation at different trifluoroethanol (TFE) concentrations were measured. TFE accelerates fibril growth at predenaturational concentrations of the alcohol. At concentrations higher than 10%, the fibrillar yield decreases proportionately as the population of an all alpha-helical, denatured form of the protein increases. At an optimum TFE concentration, the lag and the growth phases are observed, similarly to some other amyloidogenic proteins. Morphology of the protein species at the beginning and the end of the reactions was observed using atomic force microscopy and transmission electron microscopy. Final fibril morphologies differ depending on solvent conditions. 相似文献
8.
C. Faldini S. Pagkrati F. Acri M. T. Miscione D. Francesconi S. Giannini 《Journal of orthopaedics and traumatology》2007,8(3):128-133
Degenerative spondylolisthesis is characterized by the slippage of one vertebral body over the one below, with association
of intervertebral disc degeneration and degenerative arthritis of the facet joints, which cause spinal stenosis. The aim of
this study was to evaluate the clinical and radiographic results of 22 patients with symptomatic degenerative spondylolisthesis,
operated on by decompressive laminectomy and instrumented posterolateral fusion associated with interbody fusion (PLIF). Mean
age at surgery was 64 years (range, 57–72). Clinical results were evaluated on a questionnaire at the last follow-up visit
concerning postoperative low back and leg pain, restriction of daily life activities, and resumption of sports activity. Lumbar
spine radiographs were used to evaluate the status of fixation devices, the reduction of the spondylolisthesis, the lumbar
sagittal balance and the presence of spinal fusion. No intraoperative or postoperative complications were encountered. There
were no superficial or deep infections, fixation device loosening, or hardware removal. Mean follow-up time was 4 years (range,
3–6 years). Clinical outcome was excellent or good in 19 patients and fair in 3 patients. Preoperatively, mean forward vertebral
slipping on neutral lateral radiographs was 5 mm, while postoperatively it decreased to 3 mm. Preoperatively, mean sagittal
motion was 3 mm and angular motion was 8°, while postoperatively these values decreased to 1 mm and 1°, respectively. This
study demonstrated that spinal decompression followed by transpedicular instrumentation associated with PLIF technique is
a valid surgical option for the treatment of degenerative spondylolisthesis with symptomatic spinal stenosis. Clinical outcome,
intended as relief of pain and resumption of activity, was improved significantly and fusion rate was high. 相似文献
9.
Genotype-phenotype correlation for nucleotide substitutions in the IgII- IgIII linker of FGFR2 总被引:6,自引:3,他引:3
10.
In a recent paper, we showed that the number of endoneurial microvessels per square millimeter and the average luminal area and size distribution of these microvessels are not significantly different in sural nerves of patients with diabetes mellitus as compared to control subjects. Mural area, especially the component due to basement membrane reduplication and cellular debris, was unequivocally increased in diabetes mellitus. Because these latter changes are associated with a decrease in periendothelial cell area, we hypothesized that cellular degeneration, especially of pericytes, may account for basement membrane reduplication and increased frequency of cellular debris. In the present study, we showed that endoneurial microvessels undergo a statistically significant increase in basement membrane area, mural area, and frequency of cellular debris in diabetics without polyneuropathy and an even greater increase in diabetics with polyneuropathy. We also found that duration of diabetes mellitus was significantly associated with area occupied by reduplicated basement membrane and cellular debris, but not with mural and periendothelial area. None of the examined measurements was associated with age. Since the microvessel abnormalities we describe are already present before the development of polyneuropathy and increase with severity of polyneuropathy, it is likely that they reflect functional derangements of pericytes and microvessel function which precede and might be implicated in fiber degeneration. 相似文献