全文获取类型
收费全文 | 1995篇 |
免费 | 166篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 55篇 |
妇产科学 | 64篇 |
基础医学 | 303篇 |
口腔科学 | 77篇 |
临床医学 | 191篇 |
内科学 | 260篇 |
皮肤病学 | 11篇 |
神经病学 | 426篇 |
特种医学 | 53篇 |
外科学 | 279篇 |
综合类 | 14篇 |
一般理论 | 2篇 |
预防医学 | 134篇 |
眼科学 | 17篇 |
药学 | 155篇 |
中国医学 | 3篇 |
肿瘤学 | 72篇 |
出版年
2021年 | 18篇 |
2017年 | 20篇 |
2016年 | 25篇 |
2015年 | 21篇 |
2014年 | 37篇 |
2013年 | 58篇 |
2012年 | 67篇 |
2011年 | 84篇 |
2010年 | 44篇 |
2009年 | 36篇 |
2008年 | 52篇 |
2007年 | 67篇 |
2006年 | 69篇 |
2005年 | 75篇 |
2004年 | 77篇 |
2003年 | 73篇 |
2002年 | 79篇 |
2001年 | 61篇 |
2000年 | 62篇 |
1999年 | 52篇 |
1998年 | 26篇 |
1996年 | 21篇 |
1995年 | 22篇 |
1994年 | 18篇 |
1993年 | 20篇 |
1992年 | 38篇 |
1991年 | 35篇 |
1990年 | 43篇 |
1989年 | 34篇 |
1988年 | 42篇 |
1987年 | 54篇 |
1986年 | 40篇 |
1985年 | 50篇 |
1984年 | 39篇 |
1983年 | 31篇 |
1982年 | 39篇 |
1981年 | 34篇 |
1980年 | 32篇 |
1979年 | 44篇 |
1978年 | 34篇 |
1977年 | 30篇 |
1976年 | 29篇 |
1975年 | 34篇 |
1974年 | 33篇 |
1973年 | 44篇 |
1972年 | 43篇 |
1971年 | 24篇 |
1970年 | 21篇 |
1968年 | 20篇 |
1966年 | 17篇 |
排序方式: 共有2165条查询结果,搜索用时 15 毫秒
1.
Amy Y. Zhang Christopher Burant Alex Z. Fu Gerald Strauss Donald R. Bodner Lee Ponsky 《Journal of psychosocial oncology》2020,38(2):210-227
AbstractPurpose: We examined underlying psychosocial processes of a behavioral treatment for urinary incontinence (UI) of prostate cancer survivors.Design: Secondary analysis of data collected from a clinical trial.Sample: Two hundred forty-four prostate cancer survivors who participated in a clinical trial of behavioral intervention to UI as intervention or control subjects.Methods: The participants had a 3-month behavioral intervention or usual care and were followed up for an additional 3?months. They were assessed at baseline, 3, and 6?months. Latent growth curve models were performed to examine trajectories of each study variable and relationships among the variables.Findings: Increasing self-efficacy and social support were significantly and independently associated with more reduction of urinary leakage frequency over time.Implications for psychosocial oncology: Providing problem-solving skills and social support, including peer support, are essential for empowering patients to reduce UI. 相似文献
2.
3.
Serotonin (5-HT) is a mediator (through 5-HT1P receptors) of slow EPSPs in myenteric ganglia of the small intestine. The effect of 5-HT can be mimicked by elevating cAMP; therefore, we tested the hypothesis that the slow EPSP-like response to 5-HT is cAMP-mediated. Guinea pig gut was enzymatically dissociated; myenteric ganglia remained intact and were collected by filtration. Neurons in the isolated ganglia retained their ability to manifest the slow EPSP-like response to 5-HT. Exposure to 5-HT raised the ganglionic level of cAMP (ED50 0.3 μM). This effect was not antagonized by the 5-HT1P antagonist, N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide (100.0 μM), or mimicked by the 5-HT1P agonist, 5-hydroxyindalpine (10.0 μM). Increases in cAMP were also evoked by the 5-HT1 agonist, 5-carboxyamidotryptamine (10.0 μM), the 5-HT2 agonist, (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI; 1.0–10.0 μM), and by the 5-HT4 agonists, renzapride (1.0–10.0 μM) and 5-methoxytryptamine (1.0–10.0 μM); however, neither the 5-HT1/5-HT2 antagonists, spiperone, methysergide, and methiothepin, nor the 5-HT4 antagonist, tropisetron (ICS 205–930; 10.0 μM), were able to inhibit the rise in cAMP evoked by these compounds or by 5-HT (0.1–10.0 μM). The 5-HT-evoked elevation of cAMP was antagonized by ketanserin (10.0 μM), which also blocked the effects of 5-methoxytryptamine and DOI, but not those of renzapride. The effective concentration of DOI, however, was higher than that needed for activation of 5-HT2 receptors, and Northern analysis using a cDNA probe encoding the rat 5-HT2 receptor failed to reveal the presence of 5-HT2 mRNA in myenteric ganglia, although it hybridizes with mRNA of the right size in the guinea pig brain. Compounds that failed to change levels of cAMP or to antagonize the action of 5-HT included 8-hydroxy-di-n-propylamino tetralin, R58639, R88226, and sumatriptan. It is concluded that the receptor responsible for the 5-HT-induced rise in cAMP in ganglia isolated from the guinea pig myenteric plexus is not a known subtype of 5-HT receptor. Since the pharmacology of this novel receptor is different from that of the slow EPSP-like response to 5-HT, the receptor probably does not mediate the slow EPSP. © 1993 Wiley-Liss, Inc. 相似文献
4.
5.
6.
7.
8.
Psychiatric disorders in the first-degree relatives of probands with bulimia nervosa 总被引:1,自引:0,他引:1
J A Kassett E S Gershon M E Maxwell J J Guroff D M Kazuba A L Smith H A Brandt D C Jimerson 《The American journal of psychiatry》1989,146(11):1468-1471
Data from a family study of psychiatric disorders showed higher rates of major affective disorders, eating disorders, and alcoholism in first-degree relatives of 40 bulimic probands than in first-degree relatives of 24 control subjects. More importantly, the data showed higher rates of major affective disorders in relatives of bulimic probands who themselves had no history of major affective disorders than in relatives of control subjects. This significant finding indicates a familial relationship between bulimia nervosa and major affective disorders, which suggests the possibility of a common diathesis. 相似文献
9.
Michael Chorny Ilia Fishbein Haim D Danenberg Gershon Golomb 《Journal of controlled release》2002,83(3):401-414
The present study focused on in vitro release of polylactide-nanoencapsulated tyrphostin AG-1295, a potential agent for local therapy of restenosis. The drug was formulated in matrix-type nanoparticles, termed nanospheres (NS) using the nanoprecipitation method. AG-1295 is a model for low-molecular weight lipophilic compounds, the release behavior of which cannot be adequately characterized by existing methods. An in vitro release technique suitable for optimizing the nanoparticulate formulation release behavior was developed through a novel external sink method and an in situ release method utilizing the environmental sensitivity of the AG-1295 fluorescence spectrum. Similar tendencies were demonstrated by both methods in drug release studied as a function of selected NS preparation variables. The release properties of the drug fractions varying in their binding mode to the carrier particles were studied by the external sink method. The NS surface-adsorbed drug exhibited a significantly higher release rate compared to the drug entrapped in the polymeric matrix. The in situ release of the encapsulated drug was analyzed using the diffusion models of release from a matrix-type sphere. The release was shown to be a composite process, with a burst phase attributed largely to the rapid dissociation of the surface-bound AG-1295. The diffusion-controlled phase exhibited an alteration in kinetic pattern obviously due to the drug distribution between polymeric matrix compartments differing in their permeability. Drug in vitro release investigation may be effectively used to characterize the drug-carrier interaction and internal carrier structure in nanoparticulate formulations, as well as optimize the release behavior in respect to their therapeutic application. 相似文献
10.