全文获取类型
收费全文 | 1204篇 |
免费 | 77篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 23篇 |
妇产科学 | 21篇 |
基础医学 | 152篇 |
口腔科学 | 40篇 |
临床医学 | 58篇 |
内科学 | 257篇 |
皮肤病学 | 3篇 |
神经病学 | 155篇 |
特种医学 | 16篇 |
外科学 | 328篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 23篇 |
眼科学 | 39篇 |
药学 | 89篇 |
中国医学 | 1篇 |
肿瘤学 | 71篇 |
出版年
2023年 | 5篇 |
2022年 | 17篇 |
2021年 | 28篇 |
2020年 | 12篇 |
2019年 | 18篇 |
2018年 | 29篇 |
2017年 | 16篇 |
2016年 | 20篇 |
2015年 | 17篇 |
2014年 | 45篇 |
2013年 | 27篇 |
2012年 | 60篇 |
2011年 | 58篇 |
2010年 | 37篇 |
2009年 | 31篇 |
2008年 | 53篇 |
2007年 | 63篇 |
2006年 | 59篇 |
2005年 | 71篇 |
2004年 | 64篇 |
2003年 | 59篇 |
2002年 | 52篇 |
2001年 | 47篇 |
2000年 | 59篇 |
1999年 | 53篇 |
1998年 | 21篇 |
1997年 | 14篇 |
1996年 | 10篇 |
1995年 | 7篇 |
1994年 | 7篇 |
1993年 | 10篇 |
1992年 | 27篇 |
1991年 | 18篇 |
1990年 | 19篇 |
1989年 | 21篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 9篇 |
1983年 | 11篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1978年 | 9篇 |
1977年 | 6篇 |
1974年 | 5篇 |
1970年 | 5篇 |
1969年 | 5篇 |
1968年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有1283条查询结果,搜索用时 15 毫秒
1.
Lesley A. Inker Morgan E. Grams Andrew S. Levey Josef Coresh Massimo Cirillo John F. Collins Ron T. Gansevoort Orlando M. Gutierrez Takayuki Hamano Gunnar H. Heine Shizukiyo Ishikawa Sun Ha Jee Florian Kronenberg Martin J. Landray Katsuyuki Miura Girish N. Nadkarni Carmen A. Peralta Dietrich Rothenbacher Mark Woodward 《American journal of kidney diseases》2019,73(2):206-217
2.
Masanori Murakami Haruhiko Okada Masahiko Nishida Kimikazu Hamano 《Annals of thoracic and cardiovascular surgery》2006,12(3):216-218
A 14-year-old boy had a needle accidentally inserted through his chest wall. Chest X-ray showed a needle-shaped metallic density localized in the cardiac silhouette. An echocardiography indicated the needle had passed through the interventricular septum, and its eye and point had reached the right and left ventricle, respectively. Surgical removal of the needle was performed. The needle could not be observed from the heart surface, and was recognized in a dent 5 mm on the right side from the left anterior descending branch (LAD). The needle was easily removed under extracorporeal circulation, and he was discharged ten days after the operation. 相似文献
3.
K. Hamano Hiroshi Ito Andrew Bushell Kathryn J. Wood Kensuke Esato 《Transplant international》1997,10(4):293-298
In this study, the effect of combining anti-CD4 monoclonal antibody (mAb) and cyclosporin (CyA) therapy at the time of transplantation
was examined. A mouse cardiac allograft model was used. Anti-CD4 mAb administered perioperatively induces long-term survival.
The addition of a short course of CyA given subcutaneously in a regimen of either a high-dose treatment or a standard dose
treatment to the anti-CD4 mAb treatment protocol did not have a detrimental effect on graft survival. Despite having no significant
effect on graft survival, the addition of CyA to the treatment protocol did result in a significant decrease in the level
of IL-2 present in the hearts 7 days after transplantation. The decrease in IL-2 production was directly related to the presence
of CyA in vivo. When CyA treatment was continued throughout the period during which unresponsiveness to the graft is induced
by anti-CD4 mAb therapy, 50 % of the grafted hearts were rejected once the CyA was discontinued. In conclusion, the combined
use of anti-CD4 mAb therapy and CyA did not have a negative effect on graft survival in this model when the two agents were
used concurrently at the time of transplantation.
Received: 2 October 1996 Received after revision: 31 January 1997 Accepted: 5 February 1997 相似文献
4.
B A Holden J Newton-Howes L Winterton I Fatt H Hamano D La Hood N A Brennan N Efron 《Optometry and vision science》1990,67(6):476-481
The oxygen transmissibilities (Dk/L) of a set of 48 contact lenses made from 8 different materials were measured by 4 laboratories. The L/Dk measurements from each laboratory were compared and correlated. Samples which were not masked with a fixed front surface aperture during measurement were corrected for edge effects. This paper shows that provided L/Dk is calculated for each lens using the same technique and Dk is derived using a graphical method of calculation, similar results can be obtained by all laboratories. However, the agreement was less good for materials of Dk greater than 70 x 10(-11) (cm2/s) (ml O2/ml x mm Hg). 相似文献
5.
6.
S Ohnishi T Minamino Y Hamano H Saito K Yasui M Matsumoto S Fukui M Inoue T Kamada 《Journal of cardiology》1987,17(4):711-720
To determine the clinical significance of regional left ventricular asynergy in patients with impending myocardial infarction, we recorded two-dimensional echocardiograms (2DE) serially and performed coronary angiography immediately after the hospital admission in nine patients with initial impending infarction and their last anginal attacks were within 48 hours. Left ventricular asynergy on the first 2DE was observed in six of nine patients during symptom-free periods (Group A: LV asynergy group). Five of the six patients had significant coronary artery lesions (greater than or equal to 75% stenosis) in at least one major coronary artery. Intracoronary filling defects were detected in four of the five patients. Another three patients without asynergy (Group B) had significant fixed stenosis. Coronary artery spasm was observed in two patients during coronary angiography, but no patient had intracoronary filling defects. Intracoronary nitroglycerin (0.1-0.3 mg) reduced the severity of coronary artery narrowing in two patients. In addition, urokinase (240,000-480,000 IU) via the corresponding vessel (PTCR) in the remaining seven patients resulted in reduction in the severity of coronary artery stenosis in four patients, but not in the remaining three patients. Left ventricular wall movement in the asynergy group improved rapidly and no asynergy was observed by the seventh hospital day in five of the six patients. Successful PTCR treatment resulted in improvement of left ventricular wall movement. No asynergy was found in the non-asynergy group throughout their hospitalizations. These findings indicated that abnormal left ventricular wall movement is found in patients with impending myocardial infarction, even during symptom-free periods, but the wall movement gradually improves. The 2DE observations are useful for estimating the clinical status and for planning precise therapy for impending myocardial infarction. 相似文献
7.
8.
S Kikuchi Y Takehana S Hamano K Ichikawa H Komatsu T Okegawa S Ikeda 《Nihon yakurigaku zasshi. Folia pharmacologica Japonica》1990,95(3):131-137
We studied the effects of OKY-046 on types II, III and IV allergic reactions, as classified by Coombs and Gell. In Type II, OKY-046 at 30-100 mg/kg intraduodenally (i.d.) and at 1-30 mg/kg intravenously (i.v.) inhibited the bronchoconstriction in a dose-dependent manner after Forssman antigen injection. Aspirin (3 mg/kg, i.v.) also suppressed it. OKY-046 (30-100 mg/kg, i.d.) suppressed the increase of TXB2 level in the plasma in a dose-dependent manner. However, there was no effect of OKY-046 and aspirin on the decrease in complement activity (CH50), platelets and leukocytes. Additionally, OKY-046 (300 mg/kg, p.o.) prolonged the survival time following Forssman antigen injection. However, the immune hemolysis reaction was not prevented by OKY-046 (10(-6)-10(-3) M). FUT-175 protected against the Forssman shock at 1 mg/kg, i.v. and the in vitro immune hemolysis reaction at 10(-5) M. In Type III, OKY-046 (300 mg/kg, p.o.) significantly suppressed the direct passive Arthus reaction and immune complex nephritis in rats. There was no effect of OKY-046 on the delayed-type hypersensitive response to picryl chloride in mice. We think that OKY-046 should be a beneficial drug for the treatment of types II and III allergic reactions. 相似文献
9.
Corneal topographic evaluation of retinal detachment surgery 总被引:1,自引:0,他引:1
K Watanabe K Emi T Hamano S Danjo R Manabe N Maeda A Uni S Shirai R Yoshida 《Nippon Ganka Gakkai zasshi》1988,92(3):367-371
10.
Takao Kato Tsunehito Kimura Ryuhei Miyakawa Shinichi Tanaka Akiho Fujii Kazuko Yamamoto Shingo Kameoka Kyoichi Hamano Makio Kawakami Motohiko Aiba 《World journal of surgery》1997,21(1):49-56
p
= 0.0007) and tumor necrosis (TN) (HMC:
p
= 0.0050). Univariate analysis showed that AMC or HMC was a statistically significant predictor of overall survival in all
patients (
p
= 0.0086 and
p
= 0.0307, respectively). Multivariate analysis showed that AMC was an independent predictor of node status when we fitted
a model with node status, BVI, and either AMC or HMC; but HMC was not independent. However, when we fitted a model including
all 11 of the other indicators and AMC or HMC, the node status, HG, and LI were independent predictors, but AMC and HMC were
not. Although AMC was a better method than HMC for evaluating angiogenesis, we cannot confirm angiogenesis as a significant
independent prognostic factor associated with long-term survival in Japanese breast cancer patients. 相似文献