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排序方式: 共有814条查询结果,搜索用时 218 毫秒
1.
Anela Stanic Denis Rybin Francis Cannata Carole Hohl Jennifer Brody Jessie Gaeta 《AIDS care》2021,33(1):1-9
ABSTRACT The lack of stable housing can impair access and continuity of care for patients living with human immunodeficiency virus (HIV). This study investigated the relationship between housing status assessed at multiple time points and several core HIV-related outcomes within the same group of HIV patients experiencing homelessness. Patients with consistently stable housing (CSH) during the year were compared to patients who lacked CSH (non-CSH group). The study outcomes included HIV viral load (VL), CD4 counts, and health care utilization. Multivariable and propensity weighted analyses were used to assess outcomes adjusting for potential group differences. Of 208 patients, 88 (42%) had CSH and 120 (58%) were non-CSH. Patients with CSH had significantly higher proportion of VL suppression and higher mean CD4 counts. The frequency of nurse visits in the CSH group was less than a half of that in the non-CSH group. Patients with CSH were less likely to be admitted to the medical respite facility, and if admitted, their length of stay was about a half of that for the non-CSH group. Our study findings show that patients with CSH had significantly better HIV virologic control and immune status as well as improved health care utilization. 相似文献
2.
目的 探索LDH实验检测细胞活力的可行性。方法 原代培养骨髓细胞和软骨细胞,用LDH实验测定上述两组细胞的活力,并与镜下活体观察到细胞的生长状况相比较。与目前比较成熟的测定细胞活力的MTS实验的测得的值相比较。结果 LDH实验对上述两组细胞的活力的测定结果与镜下活体观察到的结果相符合。与MTS实验的测得的结果经统计学处理无显著差异。结论 LDH实验可用于细胞活力的直接测定,而对活细胞的生存、繁殖无影响。 相似文献
3.
K. J. M. Panosian A. Lopez-Beltran G. A. Croghan J. F. Gaeta M. Gamarra 《World journal of urology》1989,7(3):173-177
Summary A total of 30 urinary bladder cytological specimens (urine and bladder washings) from 25 patients were reacted with a panel of 8 monoclonal antibodies predominantly derived from urinary bladder carcinoma, using avidin-biotin complex (ABC) immunohistochemical methodology. The clinical and epidemiological history of each of the patients evaluated was also revewed. A relatively high degree of sensitivity and specificity in the detection of malignancy was obtained in tests of urinary bladder cytological specimens with a combination of monoclonal antibodies. A role for monoclonal antibodies in the diagnosis of urinary bladder cytological specimens is discussed. 相似文献
4.
L. Ressia M.D. A.M. Grande M.D. R. Gaeta M.D. G. De Pieri M.D. M. Aiello M.D. M. Viganò M.D. 《Journal of cardiac surgery》1997,12(6):431-433
A bstract Eight patients (4 men, 4 women), mean age 51 years, referred to our Institution for left atrial myxoma underwent removal of the tumor through a superior transseptal approach. All patients in sinus rhythm with normal conduction time. The myxomas were localized in the fossa ovalis (3 cases), interatrial septum (2 cases), left appendage (2 cases), and mitral annulus (1 case). One patient died in hospital after emergency operation for low-output syndrome complicated by septic shock. All other patients had an uneventful postoperative course. Atrial arrhythmias did not represent a major postoperative complication. Transient PR interval elongation was occasionally seen. Electrophysiological studies showed normal sinus node function. At 6 months following operation, patients were evaluated with transeso-phageal echocardiography. There was no tumor recurrence. There were no episodes of arrhythmia in 24-hour electrocardiographic monitoring, and all patients were in NYHA Class I. We believe that the superior transseptal approach gives optimal exposure of the left atrial cavity, overcoming all difficulties related to a small left atrium which is an usual pattern in left atrial myxomas. 相似文献
5.
W. G. Hopkins H. Gaeta A. C. Thomas P. N. Hill 《European journal of applied physiology》1987,56(1):69-73
Summary Twenty-seven children (age 7–17 years) with varying degrees of blindness but with no other known disorder were assessed for physical fitness. Twenty-seven randomly selected children with normal eyesight were also assessed. Maximum oxygen uptake (
) was measured directly during a progressive exercise test on a treadmill. There was a significant and substantial reduction in
in totally blind children (mean ± standard deviation 35.0±7.5 ml · min–1 · kg–1) compared with normal children (45.9±6.6 ml · min–1 · kg–1). Partially sighted children had a significant but smaller reduction in
. Fitness assessed by a step-test was significantly reduced in the visually impaired children, and skin-fold thickness was also significantly greater in totally blind children.The level of habitual physical activity for each child, as assessed by a questionnaire, correlated with
(r=0.53,p<0.0001). Blind children were significantly less active than normal children, and the difference between mean
for blind and normal children became non-significant when their different activity levels were taken into account. It is concluded that totally blind children are less fit than other children at least partly because of their lower level of habitual activity. 相似文献
6.
Mutations in the Ca(2+)-sensing receptor gene cause autosomal dominant and sporadic hypoparathyroidism 总被引:3,自引:0,他引:3
Baron J; Winer KK; Yanovski JA; Cunningham AW; Laue L; Zimmerman D; Cutler GB Jr 《Human molecular genetics》1996,5(5):601-606
Parathyroid hormone secretion is negatively regulated by a 7- transmembrane
domain, G-protein coupled Ca(2+)-sensing receptor. We hypothesized that
activating mutations in this receptor might cause autosomal dominant
hypoparathyroidism (ADHP). Consistent with this hypothesis, we identified,
in two families with ADHP, heterozygous missense mutations in the
Ca(2+)-sensing receptor gene that cosegregated with the disorder. None of
50 normal controls had either mutation. We also identified a de novo,
missense Ca(2+)-sensing receptor mutation in a child with severe sporadic
hypoparathyroidism. The amino acid substitution in one ADHP family affected
the N-terminal, extracellular domain of the receptor. The other mutations
involved the transmembrane region. Unlike patients with acquired
hypoparathyroidism, patients with these mutations had hypercalciuria even
at low serum calcium concentrations. Their greater hypercalciuria
presumably reflected activation of Ca(2+)-sensing receptors in kidney
cells, where the receptor negatively regulates calcium reabsorption. This
augmented hypercalciuria increases the risk of renal complications and thus
has implications for the choice of therapy.
相似文献
7.
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9.
C. Gallo G. B. Gaeta B. Galanti G. Giusti Cooperative Study Group of the Italian Society for the Study of Infectious Diseases 《European journal of epidemiology》1986,2(2):95-98
The role of surgery as an additional risk in transmitting post-transfusion hepatitis was investigated in a retrospective study on acute hepatitis occurring in 77 transfused patients, 293 transfused and operated patients and 243 hepatitis cases with history of surgery without transfusion.Hepatitis A patients admitted to the same centres in the same period were utilized as controls. In transfused patients the percentage of NANB hepatitis was higher than that of type B (61.0% vs. 36.4%), while in the operated not transfused group the percentage of type B was twice that of type NANB (63.4% vs. 32.5%).In transfused and operated cases intermediate values were observed. The age-adjusted measures of association between exposures and the different hepatitis types showed a lack of effect of transfusion and a dominant role of surgery in transmitting type B hepatitis. In contrast, NANB post-transfusional cases were actually a mixture of post-transfusional and post-surgical cases, since both these exposures were found to be significantly associated with the disease.Our results suggest that studies on the incidence and the etiology of post-transfusion hepatitis should take into account the risk of surgical exposure which might have occurred.Corresponding author. 相似文献
10.
Changes in sensitivity to stimulus deviance in Alzheimer's disease: an ERP perspective 总被引:1,自引:0,他引:1
The mismatch negativity (MMN) of the event-related brain potential (ERP) reflects the storage of information in sensory memory. MMNs were recorded from eight patients with Alzheimer's disease (AD) and eight controls to small (delta50 Hz), large (delta300 Hz), and a variety of highly deviant, environmental sounds. Both old controls and patients showed robust MMNs to all three classes of deviant events, and robust P3 compounds (indicative of active attention) to the environmental sounds. The data suggest that patients with mild AD have an intact sensory memory mechanism that responds similarly to that of controls to systematic increases in deviance. However, for both older controls and patients, only highly deviant acoustic events are likely to involuntary capture attention. 相似文献