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Noriyuki Fuku Seijiro Mori Haruka Murakami Yuko Gando Heying Zhou Hideki Ito Masashi Tanaka Motohiko Miyachi 《Geriatrics & Gerontology International》2012,12(2):292-297
Aim: Sarcopenia is the significant degenerative loss of skeletal muscle mass and strength associated with aging, and it is one of the components of frailty. We previously reported an association between the 29C>T polymorphism in the transforming growth factor‐β1 gene (rs1800470) and the prevalence of vertebral fractures in subjects with postmenopausal osteoporosis. The association was not attributable to bone mineral density, which suggests that polymorphism influences some aspects of bone quality that affects strength and/or frailty rather than bone strength itself. Thus, we examined the relationship between genetic polymorphism and lean body mass in a Japanese population. Methods: A total of 479 adults comprising 143 men and 336 women, age 23 to 85 years, participated in the present study. Fat‐free mass was measured by dual energy X‐ray absorptiometry, and the relative skeletal muscle index was calculated as the ratio of appendicular (sum of arms and legs) fat‐free mass to the square of height. Results: Total, leg, and appendicular fat‐free mass as well as the relative skeletal muscle index were significantly lower in male subjects with CT/TT genotypes compared to those with CC genotype. Female subjects did not show any genotype‐dependent differences when analyzed as a group, but when those without menstruation (postmenopausal women) were analyzed, arm fat‐free mass was significantly lower in the CT/TT genotypes than in the CC genotype. Conclusions: T allele of the 29C>T polymorphism in the transforming growth factor‐β1 gene might be a risk factor of sarcopenia in a Japanese population. Geriatr Gerontol Int 2012; 12: 292–297. 相似文献
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Pinós Tomàs Fuku Noriyuki Cámara Yolanda Arai Yasumichi Abe Yukiko Rodríguez-Romo Gabriel Garatachea Nuria Santos-Lozano Alejandro Miro-Casas Elisabet Ruiz-Meana Marisol Otaegui Imanol Murakami Haruka Miyachi Motohiko Garcia-Dorado David Hinohara Kunihiko Andreu Antoni L. Kimura Akinori Hirose Nobuyoshi Lucia Alejandro 《Age (Dordrecht, Netherlands)》2014,36(2):933-943
GeroScience - The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery... 相似文献
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Hidekazu Itoh Hidenori Nakata Shingo Nishioka Kazuyo Aikawa Yukihiro Yokoya Tuneo Nakayama Koukichi Fuku 《Digestive endoscopy》2000,12(2):191-195
This report presents a rare case of a patient with gastric cancer whose clinical course with the development of tumor from early cancer type IIc to advanced cancer of linitis plastica was observed for 9.5 years. The cancer remained in early stage for 3 years and 8 months after the patient’s first endoscopy. At 5 years and 10 months after initial endoscopy, the lesion progressed to advanced cancer, and after 6 years and 7 months sclerotic changes in the gastric wall were detected at the lesion site. After 9 years, advanced gastric cancer of linitis plastica was present throughout the stomach. The initial stage of linitis plastica is considered to be early gastric cancer type IIc with histologically undifferentiated cancer cells. It is widely accepted that a period of 6–8 years is required for this type of cancer to develop from carcinogenesis to completion of lesions. The present case is valuable in that development from early gastric cancer type IIc to linitis plastica during approximately 10 years of follow up was clinically observed, and will contribute to knowledge of the natural history of gastric cancer. 相似文献
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Nagai J Hashimoto T Togo Y Fuku K Yasuda K Nakao A Maruyama T Kondoh N Nojima M Takiuchi H Mori Y Shima H Akiyama K 《Hinyokika kiyo. Acta urologica Japonica》2005,51(10):695-697
We report a case of bladder hernia. A 68-year-old man was admitted to our hospital for the management of prostate cancer. An egg-sized soft mass was palpated at his right inguinal region. Magnetic resonance imaging and cystography revealed that the mass was a bladder hernia. During radical prostatectomy, we had to resect the bladder hernia for safe regional lymphadenectomy. This hernia was the extraperitoneal type. The stage of prostate cancer was pT3b N0 M0. This is the third reported case of inguinal bladder hernia associated with prostate cancer in Japan. 相似文献
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Tanaka M Fuku N Nishigaki Y Matsuo H Segawa T Watanabe S Kato K Yokoi K Yoko K Ito M Nozawa Y Yamada Y 《Diabetes》2007,56(2):518-521
To identify mitochondrial haplogroups that confer resistance against or susceptibility to metabolic syndrome, we performed a large-scale association study on 1,337 unrelated Japanese individuals, including 871 subjects with metabolic syndrome and 466 control subjects. Metabolic syndrome was diagnosed according to modified National Cholesterol Education Program Adult Treatment Panel III guidelines, using the cutoff point for obesity as a BMI of >/=25 kg/m(2) instead of waist circumference. The genotypes for 25 polymorphisms in the coding region of the mitochondrial genome were determined, and the haplotypes were classified into 10 major haplogroups, i.e., F, B, A, N9a, M7a, M7b, G1, G2, D5, and D4. Multivariate logistic regression analysis revealed that the haplogroup N9a was significantly associated with resistance against metabolic syndrome in women with an odds ratio (OR) of 0.21 (95% CI 0.07-0.58, P = 0.0042). Women with haplogroups G1 and D5 tended to be resistant against metabolic syndrome with an OR of 0.22 (0.06-0.68, P = 0.0129) for G1 and with an OR of 0.32 (0.10-0.96, P = 0.0469) for D5, respectively. These results indicate that mitochondrial haplogroup N9a may be a protective factor against metabolic syndrome in Japanese women. 相似文献
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Mitsuhiro Marumoto Sadao Suzuki Akihiro Hosono Kazuyuki Arakawa Kiyoshi Shibata Mizuho Fuku Chiho Goto Yuko Tokudome Hideki Hoshino Nahomi Imaeda Masaaki Kobayashi Junji Yodoi Shinkan Tokudome 《Environmental health and preventive medicine》2010,15(3):129-134
Objectives
Changes in plasma thioredoxin (TRX) concentrations before, during, and after a 130-km endurance race were measured with the aim of elucidating the relationship between exercise and oxidative stress (OS).Methods
Blood samples were taken from 18 runners participating in a 2-day-long 130-km ultra-marathon during the 2 days of the race and for 1 week thereafter. There were six sampling time points: at baseline, after the goal had been reached on the first and second day of the endurance race, respectively, and on 1, 3, and 5/6 days post-endurance race. The samples were analyzed for plasma TRX concentrations, platelet count, and blood lipid profiles.Results
Concentrations of plasma TRX increased from 17.9 ± 1.2 ng/mL (mean ± standard error of the mean) at baseline to 57.3 ± 5.0 ng/mL after the first day’s goal had been reached and to 70.1 ± 6.9 ng/mL after the second day's goal had been reached; it then returned to the baseline level 1 day after the race. Platelet counts of 21.3 ± 1.2 × 104 cell/μL at baseline increased to 23.9 ± 1.5 × 104 cells/μL on Day 1 and to 26.1 ± 1.0 × 104 cells/μL on Day 2. On Day 7, the platelet counts had fallen to 22.1 ± 1.2 × 104 cell/μL. There was a significant positive correlation between plasma TRX and platelet count.Conclusions
These data suggest that plasma TRX is an OS marker during physical exercise. Further studies are needed to determine the appropriate level of exercise for the promotion of health. 相似文献9.
Masanobu Ohya Kazushige Kadota Mamoru Toyofuku Takeshi Morimoto Hirooki Higami Yasushi Fuku Kyohei Yamaji Hiromi Muranishi Yuhei Yamaji Koji Nishida Daisuke Furukawa Tomohisa Tada Euihong Ko Kenji Ando Hiroki Sakamoto Takashi Tamura Kazuya Kawai Takeshi Kimura 《The American journal of cardiology》2017,119(3):355-364
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Norihiro Yamada Kiyoshi Shibata Mizuho Fuku Kiyonori Kuriki Chiho Goto Yuko Tokudome Machiko Miyata Kenji Maeda Hideki Hoshino Sadao Suzuki Mitsuhiro Marumoto Hiromitsu Ichikawa Hiroyuki Agawa Nami Ishikawa Kazuyuki Arakawa Akihiro Hosono Masaaki Kobayashi Shinkan Tokudome 《Sport Sciences for Health》2016,12(1):77-83