全文获取类型
收费全文 | 22907篇 |
免费 | 1462篇 |
国内免费 | 168篇 |
专业分类
耳鼻咽喉 | 208篇 |
儿科学 | 669篇 |
妇产科学 | 597篇 |
基础医学 | 3319篇 |
口腔科学 | 410篇 |
临床医学 | 1818篇 |
内科学 | 5572篇 |
皮肤病学 | 523篇 |
神经病学 | 2961篇 |
特种医学 | 597篇 |
外科学 | 2547篇 |
综合类 | 53篇 |
一般理论 | 1篇 |
预防医学 | 1235篇 |
眼科学 | 258篇 |
药学 | 1495篇 |
中国医学 | 39篇 |
肿瘤学 | 2235篇 |
出版年
2024年 | 33篇 |
2023年 | 256篇 |
2022年 | 513篇 |
2021年 | 923篇 |
2020年 | 490篇 |
2019年 | 640篇 |
2018年 | 801篇 |
2017年 | 592篇 |
2016年 | 701篇 |
2015年 | 754篇 |
2014年 | 939篇 |
2013年 | 1239篇 |
2012年 | 1775篇 |
2011年 | 1755篇 |
2010年 | 1018篇 |
2009年 | 903篇 |
2008年 | 1523篇 |
2007年 | 1438篇 |
2006年 | 1333篇 |
2005年 | 1209篇 |
2004年 | 1115篇 |
2003年 | 971篇 |
2002年 | 786篇 |
2001年 | 291篇 |
2000年 | 296篇 |
1999年 | 247篇 |
1998年 | 170篇 |
1997年 | 133篇 |
1996年 | 118篇 |
1995年 | 93篇 |
1994年 | 92篇 |
1993年 | 56篇 |
1992年 | 147篇 |
1991年 | 133篇 |
1990年 | 116篇 |
1989年 | 106篇 |
1988年 | 88篇 |
1987年 | 92篇 |
1986年 | 78篇 |
1985年 | 73篇 |
1984年 | 83篇 |
1983年 | 51篇 |
1982年 | 38篇 |
1981年 | 33篇 |
1980年 | 31篇 |
1979年 | 45篇 |
1978年 | 30篇 |
1976年 | 30篇 |
1974年 | 19篇 |
1973年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Marco Maruzzo Umberto Basso Eugenio Borsatti Laura Evangelista Filippo Alongi Orazio Caffo Francesca Maines Sara Galuppo Rocco De Vivo Fable Zustovich Dario Palleschi Andrea Zivi Teodoro Sava Mariella Sorarù Roberto Iacovelli Maurizio Nicodemo Susanne Baier Lucia Fratino Vittorina Zagonel 《Clinical genitourinary cancer》2019,17(1):e187-e194
Background
Radium 223 was introduced for metastatic castration-resistant prostate cancer based on the results of a randomized controlled trial showing risk reduction for death and skeletal events. Our aim was to evaluate the outcome of patients receiving radium 223 in a real-world setting.Patients and Methods
We conducted a multicenter retrospective analysis in the Triveneto region of Italy.Results
One hundred fifty-eight patients received radium 223 in our region. After a median follow-up of 9.5 months, 75 patients died. The median overall survival (OS) was 14.2 months, and the median progression-free survival (PFS) was 6.2 months. Seventy-one (45%) patients achieved progression as best response. Thirty-seven (23%) patients stopped the treatment early because of progression. Eastern Cooperative Oncology Group performance status was prognostic for OS (18.4 vs. 12.3 vs. 7.5 months; 0 vs. 1, P = .0062; 0 vs. 2, P = .0002), whereas previous prostatectomy or docetaxel exposure were not. A neutrophil to lymphocytes ratio ≥ 3 significantly impacted OS (18.1 vs. 9.7 months; P < .001) and slightly impacted PFS (6.6 vs. 5.6 months; P = .05). Patients with a baseline alkaline phosphatase (ALP) value ≥ 220 U/L had worse OS and PFS (24.1 vs. 10.5 months; 7.2 vs. 5.5 months; P < .001). Patients with changes in ALP value achieved better OS (P = .029) and PFS (P = .002). There was no difference according to the line of therapy (0 vs. ≥ 1; P = .490). The main grade 3/4 toxicities were anemia, asthenia, and thrombocytopenia.Conclusion
This large real-world report confirms comparable OS and PFS data when compared with the pivotal study, as well as the predictive role of ALP and neutrophil to lymphocytes ratio. The definition of the optimal position of radium 223 in the treatment of metastatic castration-resistant prostate cancer has still to be defined. 相似文献5.
6.
7.
Michele D. Mignogna Stefano Fedele Lucio Lo Russo Lorenzo Lo Muzio 《Journal of oral pathology & medicine》2003,32(4):200-205
BACKGROUND: The recurrent chronic orofacial swelling caused by orofacial granulomatosis (OFG) can cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. Although the enlargement of the lips is described to be the most common presenting complaint, the clinical onset of OFG may be characterized by minor associated mucosal and neurological manifestations, making early diagnosis very difficult or, sometimes, merely presumable. PATIENTS AND METHODS: We retrospectively analyzed the clinical manifestations of 19 patients with OFG, who were examined at our institution between 1998 and 2002, in order to determine their initial manifestations and presenting symptoms. RESULTS: A total of 10 patients showed classical recurrent enlargement of the lips (six lower; four upper) as presenting symptom. In the other nine patients, OFG onset was characterized by transient unilateral facial nerve palsy (two cases), intraoral manifestations (two cases), recurrent swelling of the periorbital area (two cases), of the chin (one case), of the zygomatic area (one case), and of the cheeks (one case). CONCLUSION: Our data underlined that OFG onset could be frequently characterized by widely variable, multiform, and temporary clinical findings. Involvement of atypical sites of the orofacial region and presence of single minor manifestations may occur as presenting symptoms, often preceding the development of traditional clinical findings. 相似文献
8.
Accuracy evaluation of image registration and segmentation tools used in conformal treatment planning of prostate cancer. 总被引:1,自引:0,他引:1
Stefania Pallotta Marta Bucciolini Serenella Russo Cinzia Talamonti Talamonti Cinzia Giampaolo Biti 《Computerized medical imaging and graphics》2006,30(1):1-7
Segmentation and registration tools are commonly used in radiotherapy for target and at risk organs localisation. In this work the performances of three different segmentation tools and of a surface matching registration technique, used on computed tomography (CT) and magnetic resonance (MR) images for the treatment planning of conformal prostate carcinoma, are studied. The accuracy of the segmentation and registration tools was evaluated by phantom experiment and on patient data, respectively. A preliminary estimate of MR image distortion was also performed. 相似文献
9.
Low signal intensity on long-repetition-time MR sequences has been observed in deep gray matter structures in patients with multiple sclerosis. This T2 shortening most likely represents a nonspecific degenerative process. We recently observed T2 shortening in the pericentral cortical gray matter and subcortical white matter in a patient with severe multiple sclerosis and we postulate that this represents an additional manifestation of neural degeneration. 相似文献
10.
Summary A case of bilateral congenital pseudarthrosis of the clavicle in a baby boy is described. The patient is fully asymptomatic, and no functional impairment is present. This is probably only the seventh case described of this rare congenital anomaly. 相似文献