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排序方式: 共有178条查询结果,搜索用时 31 毫秒
1.
F. Fotiou K. N. Fountoulakis A. Goulas L. Alexopoulos A. Palikaras 《Clinical physiology and functional imaging》2000,20(5):336-347
The aim of the current study was the introduction and standardization of two experimental conditions for dynamic pupillometry. Pupillometry is a method that can provide valuable data concerning the functioning of the autonomous nervous system. The system for recording the pupil reaction was developed in the Laboratory of Clinical Neurophysiology of the 1st Department of Neurology of Aristotle University of Thessaloniki, in co‐operation with the Laboratory of Fluid Mechanics of the Aristotle University of Thessaloniki. This system is fully automated. It includes an infra‐red video camera, which has the capacity to record in complete darkness, and an SLE (clinical photic stimulator) lamp. A software application automatically performed all the procedures. During the first experiment, one flash was administered. During the second experiment, a series of 25 flashes (1 Hz frequency) was administered. Fifty physically and mentally healthy subjects aged 23–48 years took part in the study. Means, standard deviations and ranges for all variables characterizing normal subjects during both experimental conditions are reported. Test/re‐test results and comparisons of the two eyes are also reported. The combined use of these two experimental conditions in dynamic pupillometry may be a very useful tool in medical research. There are already reports on the usefulness of pupillometry in the research of various diseases, including depression and Alzheimer’s disease. It is expected that it will also be a valuable research tool in the study of diabetes, alcoholism, myasthenia gravis, cancer, multiple sclerosis, etc. 相似文献
2.
Stanimir I. Stoilov Nikolaos Fountoulakis Angeliki Panagiotou Stephen Thomas Janaka Karalliedde 《Journal of diabetes and its complications》2021,35(5):107875
To our knowledge, there are no studies examining eGFR trajectories in an ethnically diverse cohort of T2DM patients with established DKD and long follow-up. We conducted a retrospective analysis of medical records of T2DM patients attending a specialist diabetes renal clinic in order to identify risk factors and specific eGFR trajectories associated with ESRD. There is limited information and long term follow-up on eGFR trajectories in ethnically diverse cohorts of T2DM patients with established diabetic kidney disease. We conducted a retrospective analysis of medical records of 398 T2DM patients (46.5% African-Carribean ethnicity) to identify risk factors and specific eGFR trajectories associated with end-stage renal disease (ESRD). A non-linear eGFR trajectory was observed in 59% of the 71 patients who reached ESRD. African-Caribbean ethnicity and glycaemic variability are independently associated with distinct non-linear eGFR trajectories that result in fast progression to ESRD. Clinicians should be aware that non-linear eGFR decline is frequent in patients with T2DM who have fast progression to ESRD. Predicting renal function decline based on patterns and early changes in eGFR trajectories and associated risk factors, may better enable individualized risk stratification and care for those at highest risk of rapid progression to ESRD. 相似文献
3.
Kesavan Muralidharan Mazen Ali Leonardo E. Silveira David J. Bond Konstantinos N. Fountoulakis Raymond W. Lam Lakshmi N. Yatham 《Journal of affective disorders》2013
Background
The literature on the treatment mixed episodes in Bipolar Disorder [BD] is sparse. Second generation antipsychotics [SGA] have documented efficacy in mania, but not mixed episodes. The objective of this meta-analysis was to ascertain the efficacy of SGA, either as mono- and/or adjunctive therapy, in the treatment of acute mixed episodes of BD, compared to placebo.Methods
A MEDLINE search for English language publications of randomized controlled trials [RCTs] comparing SGA with placebo in the treatment of an acute manic/mixed episode of BD, during the period 1990–2012, was performed using the terms ‘atypical antipsychotics’, ‘SGA’, ‘mixed episodes’, ‘dysphoric mania’ and each SGA independently. 9 RCTs reporting data on 1289 mixed episode patients treated with aripiprazole, asenapine, olanzapine, paliperidone-ER, risperidone, and ziprasidone, either as monotherapy or as adjunctive therapy, versus placebo, for 3–6 weeks, were included in the meta-analysis. We extracted data on the number of patients, SGA, duration of study and mean change in mania and depression scores from baseline to endpoint. Standardized mean difference between SGA and placebo for the mean baseline-to-endpoint change in mania and depression rating scores was calculated, with a 95% confidence limit.Results
SGA, either alone or in combination with mood stabilizers, had superior efficacy in treating manic symptoms of mixed episodes compared to placebo (−0.41, 95% CI −0.53, −0.30; overall effect p<0.00001). SGA were equally effective for manic symptoms in mixed episodes and pure mania (p=0.99). SGA had superior efficacy in treating depressive symptoms of mixed episodes (−0.30, 95% CI −0.47, −0.13; p<0.001) compared to placebo in two trials reporting this information.Limitations
Thirteen relevant studies could not be included as data for mixed-episodes were not presented separately.Conclusions
SGA are effective in treating acute mixed episodes of BD, with predominant manic symptoms. Their efficacy in treating depressed mixed episodes remains unclear. 相似文献4.
Konstantinos N. Fountoulakis Christos Savopoulos Melina Siamouli Eleni Zaggelidou Stamatia Mageiria Apostolos Iacovides Apostolos I. Hatzitolios 《European archives of psychiatry and clinical neuroscience》2013,263(5):441-444
For the decade 2000–2010, suicidal rates appear to be both low and stable in Greece and unrelated to the socioeconomic environment. It is highly possible that the recent crisis caused a significant increase in dysphoria, stress, depression and maybe suicidal ideation in the general population, but completed suicides do not seem to have increased so far. Measures are needed to make sure there will be no increase in completed suicides in the near future, since historically, periods of socioeconomic instability might be related to increased suicidality. Community interventions reduce stigma and enhance help-seeking. However, only those including the creation of social support networks are essential in the fight against suicidality. 相似文献
5.
Fountoulakis Konstantinos N. Panagiotidis Panagiotis Tegos Thomas Kimiskidis Vasileios Nimatoudis Ioannis 《European archives of psychiatry and clinical neuroscience》2022,272(6):1087-1096
European Archives of Psychiatry and Clinical Neuroscience - Advanced parental age at delivery and neurological soft signs (NSS) constitute risk factors for schizophrenia. The aim of the current... 相似文献
6.
7.
Fountoulakis A Zafirellis KD Dolan K Dexter SP Martin IG Sue-Ling HM 《The British journal of surgery》2004,91(8):997-1003
BACKGROUND: Surveillance programmes for Barrett's oesophagus have been implemented in an effort to detect oesophageal adenocarcinoma at an earlier and potentially curable stage. The aim of this study was to examine the impact of endoscopic surveillance on the clinical outcome of patients with adenocarcinoma complicating Barrett's oesophagus. METHOD: Consecutive patients who underwent oesophageal resection for high-grade dysplasia or adenocarcinoma arising from Barrett's oesophagus were studied retrospectively. The pathological stage and survival of patients identified as part of a surveillance programme were compared with those of patients presenting with symptomatic adenocarcinoma. RESULTS: Seventeen patients in the surveillance group and 74 in the non-surveillance group underwent oesophagectomy. Disease detected in the surveillance programme was at a significantly earlier stage: 13 of 17 versus 11 of 74 stage 0 or I, three versus 26 stage II, and one versus 37 stage III or IV (P < 0.001). Lymphatic metastases were seen in three of 17 patients in the surveillance group and 42 of 74 who were not under surveillance (P = 0.004). Three-year survival was 80 and 31 per cent respectively (P = 0.008). CONCLUSION: Patients with surveillance-detected adenocarcinoma of the oesophagus are diagnosed at an earlier stage and have a better prognosis than those who present with symptomatic tumours. 相似文献
8.
Concomitant alterations of metabolic parameters,cardiovascular risk factors and altered cortisol secretion in patients with adrenal incidentalomas during prolonged follow‐up 下载免费PDF全文
9.
Biological rhythms have always been considered to be disrupted in depression, with the predominant theory being that of hyperarousal.
However, recent data suggest that it might be more appropriate to suggest that depressed patients are incapable of achieving
and maintaining the particular level of internal homeostasis which permits them to function smoothly, to lower the level of
arousal during sleep sufficiently so that quality of sleep is good, and to increase this level enough during the day so the
person can function properly. Therefore, the transition from one state to another is somewhat problematic, delayed, incomplete
and desynchronised. Thus, agents with a 'rhythm stabilising' effect could be beneficial in the treatment of mood disorders.
Such an agent should have a beneficial effect on restoring and stabilising the rhythm of a physiological function while not
pushing it towards a specific pole, or inducing the opposite pole; it should also allow response to internal and environmental
stimuli and zeitgebers, and restore synchronisation of the various body rhythms while not inducing or worsening desynchronisation.
Agomelatine could represent the first of a new class of 'rhythm stabilising antidepressants', but further research is necessary
to support this theory. 相似文献
10.