全文获取类型
收费全文 | 6397篇 |
免费 | 419篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 167篇 |
儿科学 | 124篇 |
妇产科学 | 88篇 |
基础医学 | 720篇 |
口腔科学 | 174篇 |
临床医学 | 563篇 |
内科学 | 1694篇 |
皮肤病学 | 104篇 |
神经病学 | 808篇 |
特种医学 | 198篇 |
外科学 | 1067篇 |
综合类 | 12篇 |
一般理论 | 1篇 |
预防医学 | 261篇 |
眼科学 | 90篇 |
药学 | 431篇 |
中国医学 | 9篇 |
肿瘤学 | 350篇 |
出版年
2024年 | 5篇 |
2023年 | 61篇 |
2022年 | 144篇 |
2021年 | 227篇 |
2020年 | 120篇 |
2019年 | 185篇 |
2018年 | 218篇 |
2017年 | 146篇 |
2016年 | 184篇 |
2015年 | 188篇 |
2014年 | 259篇 |
2013年 | 332篇 |
2012年 | 456篇 |
2011年 | 458篇 |
2010年 | 267篇 |
2009年 | 284篇 |
2008年 | 409篇 |
2007年 | 401篇 |
2006年 | 363篇 |
2005年 | 392篇 |
2004年 | 376篇 |
2003年 | 315篇 |
2002年 | 268篇 |
2001年 | 75篇 |
2000年 | 71篇 |
1999年 | 77篇 |
1998年 | 74篇 |
1997年 | 40篇 |
1996年 | 42篇 |
1995年 | 34篇 |
1994年 | 42篇 |
1993年 | 20篇 |
1992年 | 36篇 |
1991年 | 31篇 |
1990年 | 31篇 |
1989年 | 37篇 |
1988年 | 26篇 |
1987年 | 25篇 |
1986年 | 26篇 |
1985年 | 21篇 |
1984年 | 15篇 |
1983年 | 21篇 |
1982年 | 9篇 |
1980年 | 8篇 |
1979年 | 8篇 |
1978年 | 3篇 |
1976年 | 3篇 |
1969年 | 3篇 |
1968年 | 9篇 |
1967年 | 2篇 |
排序方式: 共有6861条查询结果,搜索用时 15 毫秒
1.
2.
3.
I. Udroiu A. Sgura L. Vignoli M.A. Bologna M. D'Amen D. Salvi A. Ruzza A. Antoccia C. Tanzarella 《Environmental and molecular mutagenesis》2015,56(4):412-417
The amphibian micronucleus test has been widely used during the last 30 years to test the genotoxic properties of several chemicals and as a tool for ecogenotoxic monitoring. The vast majority of these studies were performed on peripheral blood of urodelan larvae and anuran tadpoles and to a lesser extent adults were also used. In this study, we developed protocols for measuring micronuclei in adult shed skin cells and larval gill cells of the Italian crested newt (Triturus carnifex). Amphibians were collected from ponds in two protected areas in Italy that differed in their radon content. Twenty‐three adult newts and 31 larvae were captured from the radon‐rich pond, while 20 adults and 27 larvae were taken from the radon‐free site. The animals were brought to the laboratory and the micronucleus test was performed on peripheral blood and shed skins taken from the adults and on larval gills. Samples from the radon‐rich site showed micronucleus frequencies higher than those from the radon‐free site and the difference was statistically significant in gill cells (P < 0.00001). Moreover, the larval gills seem to be more sensitive than the adult tissues. This method represents an easy (and noninvasive in the case of the shed skin) application of the micronucleus assay that can be useful for environmental studies in situ. Environ. Mol. Mutagen. 56:412–417, 2015. © 2014 Wiley Periodicals, Inc. 相似文献
4.
Paolo Mazzone Fabrizio Stocchi Salvatore Galati Angelo Insola Maria Grazia Altibrandi Nicola Modugno Domenicantonio Tropepi Livia Brusa Alessandro Stefani 《Neuromodulation》2006,9(3):221-228
Objectives. Traditional deep brain stimulation (DBS) at the subthalamic nucleus (STN) has proved to be efficacious on core Parkinsonian symptoms. However, very disabling l ‐dopa–induced abnormal involuntary movements (AIMs) and axial signs are slightly affected, suggesting that we target less conventional targets. Our candidates for DBS were the globus pallidus internus (GPi) plus the intralaminar thalamic complex (Pf or CM), given its extensive functional links with basal ganglia nuclei. Materials and Methods. The routine utilization of our innovative stereotactic apparatus allows us to implant, at the same time, both the CM‐Pf complex together with the GPi in six Parkinson disease patients. Both intraoperative and postoperative neurophysiologic assessments helped us recognize functional subregions while optimizing implantation of electrodes. Unified Parkinson disease rating scale (UPDRS) motor scores, AIMs, and freezing were carefully blindly evaluated for each condition. Results. A significant amelioration of UPDRS scores was achieved by simultaneous activation of both targets. CM‐Pf activation was only slightly effective in reducing rigidity and akinesia, but more efficacious on freezing. Not surprisingly, AIMs were peculiarly decreased by the activation of the permanent electro‐catheter in the posteroventral GPi. Conclusions. These findings confirm that, in selected patients, it is conceivable to target structures other than the conventional STN in order to maximize clinical benefit. 相似文献
5.
Lucio Posteraro Fabrizio Pezzoni Emilio Varalda Gloria Fugazza Anna Mazzucchi 《Journal of neurology》1991,238(6):337-339
Summary A patient who developed a unilateral opercular syndrome following a cerebrovascular accident is described. Computed tomography showed that the lesion did not affect the opercular cortex, but involved deep white matter and the head of the caudate nucleus of the left hemisphere. Persistent hypophonia and transient aphasia were associated. Comparison with previous cases is discussed. 相似文献
6.
Enza-Maria Valente Anjum Misbahuddin Francesco Brancati Mark R Placzek Barbara Garavaglia Sergio Salvi Andrea Nemeth Charles Shaw-Smith Nardo Nardocci Anna-Rita Bentivoglio Alfredo Berardelli Roberto Eleopra Bruno Dallapiccola Thomas T Warner 《Movement disorders》2003,18(9):1047-1051
The epsilon-sarcoglycan gene (SGCE) on human chromosome 7q21 has been reported to be a major locus for inherited myoclonus-dystonia. Linkage to the SGCE locus has been detected in the majority of families tested, and mutations in the coding region have been found recently in families with autosomal dominant myoclonus-dystonia. To evaluate the relevance of SGCE in myoclonus-dystonia, we sequenced the entire coding region of the epsilon-sarcoglycan gene in 16 patients with either sporadic or familial myoclonus-dystonia. No mutations were found. This study suggests that epsilon-sarcoglycan does not play an important role in sporadic myoclonus-dystonia and supports genetic heterogeneity in familial cases. 相似文献
7.
8.
9.
10.
Empty Sella and Headache 总被引:2,自引:0,他引:2
Teresa Catarci Fabrizio Fiacco Luigi Bozzao Manuela Pati Alice Valeria Magiar Rosanna Cerbo 《Headache》1994,34(10):583-586
SYNOPSIS
Empty sella is an anatomical condition caused by herniation of the subarachnoid space into the pituitary fossa through an incompetent seller diaphragm. Headache seems to be one of the most frequently reported symptoms. We studied 13 headache patients (12 females, 1 male) presenting with primary empty sella (PES) on CT scan. The characteristics of the headache were analyzed and plasma levels of pituitary hormones or cortisol assessed. We confirmed the nonspecific nature of the headache in PES even though the majority of our patients complained of daily headache, mostly localized anteriorly. Hormone plasma levels were within normal range in all the patients assessed. However, four patients reported earlier endocrine disorders and more than half of the patients presented with obesity.
In our opinion, PES should be suspected in middle-aged overweight women with daily headache even in the absence of endocrine symptomatology. 相似文献
Empty sella is an anatomical condition caused by herniation of the subarachnoid space into the pituitary fossa through an incompetent seller diaphragm. Headache seems to be one of the most frequently reported symptoms. We studied 13 headache patients (12 females, 1 male) presenting with primary empty sella (PES) on CT scan. The characteristics of the headache were analyzed and plasma levels of pituitary hormones or cortisol assessed. We confirmed the nonspecific nature of the headache in PES even though the majority of our patients complained of daily headache, mostly localized anteriorly. Hormone plasma levels were within normal range in all the patients assessed. However, four patients reported earlier endocrine disorders and more than half of the patients presented with obesity.
In our opinion, PES should be suspected in middle-aged overweight women with daily headache even in the absence of endocrine symptomatology. 相似文献