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1.
E.K. Lavu FRCPA M. Nelson M.Sc PhD H.J. Popp AAIMS BA J. Gibson FRCP FRCPA PhD H. Kronenberg DCP FRCP FRCPA FRCPath H. Pearson FAIMS A. Child FRCOG 《The Australian & New Zealand journal of obstetrics & gynaecology》1997,37(2):180-183
Summary: regnant women who attended antenatal clinics at King George V Hospital, the Birth Centre or were referred by obstetricians from February to July. 1996 were screened for the platelet antigen HPA-la by flow cytometry. Forty out of 2300 (1.7%) were found to be negative for this antigen . Of the 28 women followed throughout their pregnancy, none developed antibody to HPA-la. Platelet counts performed on samples from 17 babies born to 17 of these mothers were all normal. This study proves the simplicity and rapidity of flow cytometry for platelet antigen screening. The results were comparable with the Solid Phase Red Cell Adherence (SPRCA) method and with PCR. The lack of a plentiful supply of specific antibody and the rarity of fetomaternai alloimmune thrombocytopenia (FMAIT) argue against the introduction of routine screening for maternal HPA-la status at the present time. 相似文献
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Melvin LH Ling BMed MD Jason Yosar MBBS Brendon WH Lee BMed Saumil A Shah BMed MD Ivy W Jiang BMed Anna Finniss FRACP Alexandra Allende FRCPA PhD Ian C Francis FRACS FRANZCO PhD 《Clinical & experimental optometry》2020,103(5):572-582
Temporal arteritis (TA), or giant cell arteritis, is a systemic autoimmune vasculitis affecting patients over 50 years of age. It can cause rapid, irreversible bilateral vision loss in older adults and is therefore considered an ophthalmological emergency. Many of the symptoms and signs of TA can be vague, non-specific and gradual in onset, often leading to a delayed or inaccurate diagnosis. As such, it is important for a wide variety of primary optometrists and health practitioners to maintain a robust understanding of the clinical presentation, key investigations and time-sensitive management of this disease, as early initiation of treatment for TA can be vision- and life-saving. 相似文献
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Naresh Kumar FRCS Qasim Ahmed Diplomate ABPath Victor K. M. Lee FRCPA Yongsheng Chen MRCS Aye Sandar Zaw MPH Raymond Goy FANZCA Rohit Vijay Agrawal FANZCA Aisha Naheed Dhewar MSc Hee Kit Wong MChOrth 《Annals of surgical oncology》2014,21(7):2436-2443
Background
Intraoperative cell salvage (IOCS) has been used in musculoskeletal surgery extensively. However, it has never found its place in musculoskeletal oncologic surgery. We have conducted the first-ever study to evaluate the feasibility of IOCS in combination with a leucocyte-depletion filter (LDF) in metastatic spine tumor surgery. This was to pave the path for use of IOCS-LDF in musculoskeletal oncologic surgery.Methods
Patients with a known primary epithelial tumor, who were offered surgery for metastatic spinal disease, were recruited. Blood samples were collected at three different stages during the surgery: from the operative field before IOCS processing, after IOCS processing, and after IOCS-LDF processing. Three separate samples (5 mL each) were taken at each stage. Samples were examined using immunohistochemical monoclonal antibodies to identify tumor cells of epithelial origin.Results
Of 30 patients in the study, 6 were excluded for not fulfilling the inclusion criteria, leaving 24 patients. Malignant tumor cells were detected in the samples from the operative field before IOCS processing in eight patients and in the samples from the transfusion bag after IOCS processing in three patients. No viable malignant cell was detectable in any of the blood samples after passage through both IOCS and LDF.Conclusions
The findings support the notion that the IOCS-LDF combination works effectively in eliminating tumor cells from salvaged blood, so this technique can be applied successfully in spine tumor surgery. This concept can then further be extended to whole musculoskeletal tumor surgery and other oncologic surgeries with further appropriate clinical studies. 相似文献10.