全文获取类型
收费全文 | 385篇 |
免费 | 11篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 2篇 |
妇产科学 | 23篇 |
基础医学 | 59篇 |
口腔科学 | 5篇 |
临床医学 | 27篇 |
内科学 | 92篇 |
皮肤病学 | 5篇 |
神经病学 | 9篇 |
特种医学 | 3篇 |
外科学 | 54篇 |
综合类 | 26篇 |
一般理论 | 2篇 |
预防医学 | 40篇 |
眼科学 | 7篇 |
药学 | 26篇 |
肿瘤学 | 3篇 |
出版年
2018年 | 2篇 |
2017年 | 5篇 |
2015年 | 2篇 |
2010年 | 5篇 |
2009年 | 2篇 |
2008年 | 2篇 |
2005年 | 2篇 |
2001年 | 2篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1997年 | 5篇 |
1996年 | 9篇 |
1995年 | 7篇 |
1994年 | 5篇 |
1993年 | 12篇 |
1992年 | 3篇 |
1991年 | 12篇 |
1990年 | 8篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 7篇 |
1985年 | 2篇 |
1984年 | 6篇 |
1983年 | 3篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1973年 | 2篇 |
1971年 | 2篇 |
1970年 | 1篇 |
1967年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1963年 | 14篇 |
1962年 | 3篇 |
1961年 | 3篇 |
1960年 | 5篇 |
1959年 | 18篇 |
1958年 | 27篇 |
1957年 | 29篇 |
1956年 | 27篇 |
1955年 | 23篇 |
1954年 | 39篇 |
1949年 | 14篇 |
1948年 | 28篇 |
1947年 | 6篇 |
排序方式: 共有396条查询结果,搜索用时 31 毫秒
1.
S. G. WOOLFREY J. HEGBRANT H. THYSELL P. A. FOX D. W. LENDREM G. F. LOCKWOOD K. LASHER J. ROGERS D. GREENSLADE 《The Journal of pharmacy and pharmacology》1995,47(8):651-655
This study was designed to test a proposed dose modification for intravenous milrinone in congestive heart failure patients (CHF, NYHA I-II) with either moderate or severe renal impairment. All the patients were administered an intravenous loading dose of drug at 50 μg kg-1 over 10 min. This was followed by an 18 h maintenance infusion of milrinone at 0·45 or 0·35 μg kg?1 min?1 for the moderate (chromium-EDTA clearance of 31–75 mL min?1, n = 10) and severe renally impaired subjects (chromium-EDTA of clearance 10–30 mL min?1, n = 11), respectively. Plasma and urine samples were collected for up to 34 h and analysed for parent drug by validated HPLC methods. The mean (± s.d.) steady-state plasma concentrations of milrinone were within the therapeutic range (100–300 ng mL?1) for both groups, with values of 239 ± 71 ng mL?1 and 269 ± 32 ng mL?1 for the moderate and severe patients, respectively. No statistical differences were observed between the steady-state values for the two groups. With the exception of two patients per group, individual steady-state levels were also within the therapeutic range. Those outside the nominal range showed steady-state levels, ranging between 308 and 353 ng mL?1, that were not associated with any serious adverse events. As predicted for this highly renally cleared drug, there were differences (P < 0·001) in the total plasma clearance (CLP), renal clearance (CLr), and plasma terminal half-life (t1/2) of drug, with values in the severe group being 44% lower, 75% lower, and about 134% longer respectively, when compared with the moderate group. High (correlation coefficient > 0·8) and significant correlations (P < 0·001) were observed between CLP and CLr and the degree of renal impairment (chromium-EDTA clearance). The apparent volume of distribution was approximately 40% higher (P < 0·01) in the severe group compared with that for the moderate group (moderates were 0·443 ± 0·155 L kg?1). This volume difference suggests a decrease in the plasma protein-binding of milrinone because of the renal disease. The fraction of drug excreted in the urine was 0·705 ± 0·100 for the moderate group and 0·320 ± 0·089 for the severe group (P < 0·001). These results may suggest an increase in non-renal clearance of the compound, representing a partial compensation mechanism for the reduced renal function. In conclusion, this study has confirmed that the current dose reductions recommended for the use of intravenous milrinone in CHF patients with impaired renal function will yield plasma concentrations of the drug within the therapeutic range. 相似文献
2.
3.
4.
5.
Pre-anesthetic hypnosis with rectal pentothal in children 总被引:1,自引:0,他引:1
6.
Fluoxetine treatment of depression and associated self-injury in two adults with mental retardation 总被引:1,自引:0,他引:1
R. SOVNER C. J. FOX M. J. LOWRY M. A. LOWRY 《Journal of intellectual disability research : JIDR》1993,37(3):301-311
ABSTRACT. The use of fluoxeiine to treat chronic depression and associated self-injurious behaviour (SIB) in a woman with severe mental retardation and a man with profound mental retardation is reported. In the first case, behavioural monitoring of treatment response revealed a dramatic decrease in SIB and a normalization of the woman's sleep disturbance. In the second case, SIB and the use of mechanical restraint decreased substantially. In both cases, anecdotal reports also indicated a diminution of other depressive symptoms. These cases highlight the need to consider an affective disorder as a cause of SIB in persons with severe and profound developmental disabilities. The behaviour monitoring system proved to be a practical aid in the diagnosis of depression and evaluation of antidepressant treatment in individuals who were incapable of self-report. 相似文献
7.
Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14 总被引:2,自引:0,他引:2
G. T. GILLETT M. F. FOX P. S. N. ROWE C. M. CASIMIR S. POVEY 《Annals of human genetics》1996,60(3):201-211
Cofilin is a widely-distributed, intracellular, actin binding protein which is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. We have cloned a non-muscle-type cofilin (CFL1) from a human promyelocytic cDNA library and mapped this to human chromosome 11 by PCR amplification of 3' untranslated sequence in a panel of rodent-human somatic cell hybrids, and to the interval 11q12-q13.2 in a chromosome 11 somatic cell hybrid mapping panel. Confirmation of regional localisation to 11q13 has been obtained by fluorescent in situ hybridisation of genomic cosmid clones, by demonstration of the presence of both SEA (the human homologue of avian retrovirus pro viral tyrosine kinase, 11q13) and CFL1 in some of these clones and by close linkage of CFL1 to SEA in a panel of high-dose irradiation hybrids.
We have identified human muscle-type cofilin sequences by comparison of human expressed sequence tags with M-type cofilins of other species and we have mapped the human M-type cofilin, CFL2, to chromosome 14. 相似文献
We have identified human muscle-type cofilin sequences by comparison of human expressed sequence tags with M-type cofilins of other species and we have mapped the human M-type cofilin, CFL2, to chromosome 14. 相似文献
8.
In an immunocytochemical study of 41 human lung tumours we have shown that Langerhans cells can be reliably identified using the anti-CD1 monoclonal antibody NA1/34. Langerhans cells are present in all the main varieties of human lung tumour although they are infrequent in both small cell carcinoma and carcinoid tumour. There is considerable variation in numbers of Langerhans cells in both adenocarcinomas and squamous cell carcinomas. In this study tumours were divided into those with high numbers of Langerhans cells (greater than 2 per high power field) and those with low numbers (less than 2 per high power field). Analysing these results against patient survival showed a markedly worse survival in those tumours with a high number of Langerhans cells for all the tumours as a single group and for squamous cell carcinoma as a single entity. 相似文献
9.
Mouse Liver Carcinogenesis: Mechanisms and Relevance 总被引:6,自引:5,他引:1
GOODMAN JAY I.; WARD JERROLD M.; POPP JAMES A.; KLAUNIG JAMES E.; FOX TONY R. 《Toxicological sciences》1991,17(4):651-665
Symposium Overview: Mouse Liver Carcinogenesis: Mechanisms andRelevance. GOODMAN, J. I., WARD, J. M., POPP, J. A., KALUNIG,J. E., AND FOX, T. R. (1991). Fundam. Appl. Toxicol. 17, 651665. 相似文献
10.
FOX K.; POOL J.; VOS J.; LUBSEN J.; ON BEHALF OF THE ROCKET-STUDY GROUP 《European heart journal》1991,12(9):1283-1287
This study was designed to examine the effects of nisoldipine(relative to placebo), a new dihydropyridine calcium entry blockingagent, in the treatment of silent ischaemia in conventionaldoses. A total of 409 patients with proven coronary artery diseasewere screened and of this 64 had at least six episodes or atotal duration of 30 mm of ST segment depression (1 mm lastingat least 1 min) over 48 h. Fifty-two patients ultimately completeda randomized double-blind cross-over study comparing nisoldipine5 mg twice a day, nisoldipine 10 mg daily and placebo. There was a reduction in the ST segment integral and numberof episodes of ST segment depression when compared to placeboon treatment with nisoldipine 5 mg twice a day and nisoldipine10 mg daily. However, the confidence limits were wide and crossedthe no-treatment effect line. In addition, the nisoldipine dosesneither affected the circadian distribution of ischaemic episodesnor caused an alteration of the workload achieved either atpeak exercise or at 1 mm ST segment depression measured 24 hafter nidoldipine 10 mg or 12 h after nisoldipine 5 mg. We conclude that frequent silent ischaemia in patients withproven coronary artery disease is relatively uncommon, it accountsfor approximately 16% of patients with positive exercise. Inthese patients nisoldipine, given as 5mg twice a day and 10mg daily, showed no significant therapeutic effects, eitheron the frequency or severity of silent ischaemia. New formulationsof slow release nisoldipine are consequently being developedso that a fuller 24 h therapeutic profile may be obtained. 相似文献