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1.
FILIPPO DE LUCA PHILIPPE DUQUESNOY TERESA ARRIGO FORTUNATO LOMBARDO MICHEL GOOSSENS 《Acta paediatrica (Oslo, Norway : 1992)》1991,80(12):1235-1240
ABSTRACT. This case report concerns a 7-month-old infant with severe height retardation (–5.0 SD), typical growth hormone (GH)-deficient phenotype, and undetectable GH serum levels in response to three pharmacological stimuli. Diagnosis of isolated GH deficiency type 1A was confirmed by restriction endonuclease analysis of genomic DNA which pointed out GH-N gene deletion. The introduction of bio-methionyl-GH therapy in this patient was followed by a transient and clinically irrelevant appearance of low binding capacity GH antibodies as well as by a long-lasting catch-up growth (42.2 cm) which is continuing 44 months after beginning of treatment. This atypical pattern confirms that immune and growth response to exogenous GH in isolated GH deficiency 1A may be very heterogeneous. 相似文献
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Different Trends of Changes in Heart Rate Variability in Patients with Anterior and Inferior Acute Myocardial Infarction 总被引:2,自引:0,他引:2
MARIA VITTORIA PITZALIS FILIPPO MASTROPASQUA FRANCESCO MASSARI REA PASSANTINO GIOVANNI LUZZI LUANA LIGURGO ROBERTO COLOMBO MARIA GIUSEPPINA BIASCO PAOLO RIZZON 《Pacing and clinical electrophysiology : PACE》1998,21(6):1230-1238
Modifications in heart rate variability (HRV) parameters occur after acute myocardial infarction. The aim of this study was to evaluate the trend of HRV change during the acute phase and the first month after myocardial infarction, and establish whether they were affected by the anterior or inferior location of the infarction. The time-domain HRV measures of 59 patients with a first uncomplicated acute myocardial infarction were computed from 24-hour ECG recordings made on days 1, 2, 10, and 28 after hospital admission. At day 1, the mean RR cycle length (NN), the standard deviation of the NN intervals (SDNN), and the root mean square successive difference of NN intervals (RMSSD) were lower in the patients with anterior myocardial infarction. Although the parameters were similar in all of the patients at day 28, their behavior over time was different (P = 0.01): the SDNN in the patients with inferior myocardial infarction had decreased to the values found in anterior myocardial infarction patients by day 2 but, at day 10, both NN and SDNN tended to recover in both groups; RMSSD had diminished in both groups by day 2, but at day 10, had increased in the patients with anterior, but not in those with inferior myocardial infarction. These findings suggest that (1) in the very early phase of myocardial infarction, HRV is different in the two locations, (2) during the first hours of myocardial infarction patients with inferior location showed a greater vagal activity than patients with anterior location that became lower at day 10, and (3) the recovery of HRV is an early phenomenon in both groups, being already evident by the second week after myocardial infarction. 相似文献
3.
Device Longevity in a Contemporary Cohort of ICD/CRT‐D Patients Undergoing Device Replacement
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FRANCESCO ZANON M.D. F.E.S.C. F.H.R.S. CRISTIAN MARTIGNANI M.D. ERNESTO AMMENDOLA M.D. ENDRJ MENARDI M.D. MARIA LUCIA NARDUCCI M.D. Ph.D. PAOLO DE FILIPPO M.D. MATTEO SANTAMARIA M.D. ANDREA CAMPANA M.D. GIUSEPPE STABILE M.D. DOMENICO ROSARIO POTENZA M.D. GIANNI PASTORE M.D. MATTEO IORI M.D. CONCETTO LA ROSA M.D. MAURO BIFFI M.D. 《Journal of cardiovascular electrophysiology》2016,27(7):840-845
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RENZO COLOMBO LUIGI FILIPPO DA POZZO AVIGDOR LEV ANDREA SALONIA PATRIZIO RIGATTI ZVI LEIB CIRO SERVADIO EMANUELE CALDARERA MICHELE PAVONE-MACALUSO 《The Journal of urology》1998,159(3):783-787