全文获取类型
收费全文 | 2325篇 |
免费 | 143篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 39篇 |
妇产科学 | 29篇 |
基础医学 | 298篇 |
口腔科学 | 39篇 |
临床医学 | 193篇 |
内科学 | 638篇 |
皮肤病学 | 41篇 |
神经病学 | 186篇 |
特种医学 | 108篇 |
外科学 | 275篇 |
综合类 | 6篇 |
预防医学 | 60篇 |
眼科学 | 59篇 |
药学 | 201篇 |
中国医学 | 3篇 |
肿瘤学 | 272篇 |
出版年
2024年 | 3篇 |
2023年 | 16篇 |
2022年 | 35篇 |
2021年 | 68篇 |
2020年 | 44篇 |
2019年 | 49篇 |
2018年 | 71篇 |
2017年 | 59篇 |
2016年 | 61篇 |
2015年 | 63篇 |
2014年 | 101篇 |
2013年 | 86篇 |
2012年 | 148篇 |
2011年 | 168篇 |
2010年 | 91篇 |
2009年 | 74篇 |
2008年 | 112篇 |
2007年 | 143篇 |
2006年 | 176篇 |
2005年 | 113篇 |
2004年 | 113篇 |
2003年 | 111篇 |
2002年 | 133篇 |
2001年 | 46篇 |
2000年 | 40篇 |
1999年 | 39篇 |
1998年 | 30篇 |
1997年 | 21篇 |
1996年 | 25篇 |
1995年 | 13篇 |
1994年 | 16篇 |
1993年 | 14篇 |
1992年 | 28篇 |
1991年 | 21篇 |
1990年 | 12篇 |
1989年 | 12篇 |
1988年 | 23篇 |
1987年 | 11篇 |
1986年 | 14篇 |
1985年 | 14篇 |
1984年 | 14篇 |
1983年 | 5篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1971年 | 2篇 |
1969年 | 4篇 |
1967年 | 2篇 |
1966年 | 5篇 |
排序方式: 共有2478条查询结果,搜索用时 31 毫秒
1.
Daisuke Kubota Chizuru Takishima Ken-ichi Ishii Takahiro Kawamura Tomoko Matsumoto Yasuhiro Itsui Eriko Okada Seishin Chin Shinya Oooka Kiichiro Tsuchiya Akihiro Araki Naoya Sakamoto Tatsuya Miyata Takanori Kanai Mamoru Watanabe 《Nihon Shokakibyo Gakkai zasshi》2006,103(9):1044-1049
A 23-year-old man was admitted for treatment of acute exacerbation of ileitis and perianal abscess caused by Crohn's disease. After incision and drainage of the abscess, coupled with antibiotic therapy, 6-mercaptopurine (6-MP) was commenced. His white blood cell (WBC) count on day 12 after initiation of 6-MP was not decreased. However, on day 24 he was re-admitted because of severe myelosuppression (WBC: 300/microl), which was complicated by the recurrence of the perianal abscess. Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level. 相似文献
2.
Yosiaki Yajima Nobutaka Takahashi Atsusi Miyazaki Ryosuke Kikuchi Keisuke Kakisaka Keisuke Oikawa Kazuhiko Sugawara Yoshiki Eda Hiroshi Naganuma Masamitsu Unagami 《Nihon Shokakibyo Gakkai zasshi》2006,103(5):515-522
From April 1989 to December 2004, we performed liver biopsy on 475 patients and obtained biopsy proven 35 cases of non-alcoholic fatty liver. Among them, 18 cases were diagnosed as non-alcoholic steatohepatitis (NASH). During the last three years, we have tried to detect NASH using ultrasonography and elevated value of serum ferritin (> 300 ng/ml). All of the eligible 7 cases biopsied during the course were diagnosed as NASH. In these 7 cases, ALT levels improved after the body weight loss accompanied by the parallel decrease of serum ferritin levels. Measurement of serum ferritin is useful in the detection of NASH but the normal value of ferritin cannot rule out the possibility of NASH. 相似文献
3.
Daisuke Kubota Takanori Kanai Fumiro Yui Tomoko Matsumoto Takahiro Kawamura Yasuhiro Itsui Eriko Okada Seishin Chin Shinya Ooka Masakazu Nagahori Kiichiro Tsuchiya Akihiro Araki Naoya Sakamoto Tatsuya Miyata Mamoru Watanabe 《Nihon Shokakibyo Gakkai zasshi》2007,104(1):42-46
A 44-year-old women developed marked myopathy one year earlier, when she was treated with intravenous prednisolone for acute severe exacerbation of ulcerative colitis. When she was admitted to our hospital for another severe exacerbation, intravenous cyclosporine A was administered as monotherapy because she could not tolerate corticosteroid. The treatment was successful and she obtained complete remission. Cyclosporine A monotherapy is considered to be a valuable alternative to proctocolectomy for severe ulcerative colitis patients who cannot tolerate corticosteroid. 相似文献
4.
Hirotaka Inaba Kazuhiko Higuchi Kenji Koseni Haruo Yamauchi Junichi Naganuma 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(11):587-592
OBJECTIVE: The aortic connector system was used to minimize cerebrovascular complications when performing the proximal anastomosis of vein grafts during coronary artery bypass grafting (CABG). The goal of this study was to investigate the intermediate outcomes of patients undergoing CABG with the aortic connector system. METHODS: The aortic connector was used on nine patients undergoing CABG between November 2002 and July 2003. Intermediate outcomes of the patients were examined, and the results of coronary angiography, which were performed before patient discharge and at least 6 months after discharge, were evaluated. RESULTS: There were no operative deaths or cerebrovascular accidents. One patient died 9 months after discharge, one patient had angina, and the remaining seven patients were asymptomatic. When evaluating the results of angiography performed before patient discharge, two of the 21 distal vein graft anastomoses were occluded (patency rate, 90.5%), but there was no stenosis or occlusion at the proximal anastomoses sites that were performed using the aortic connector. When evaluating the results of the second angiography performed after patient discharge, four of the eight proximal anastomoses were patent, one was completely occluded, two had 90% stenosis and one had 75% stenosis. Further, four of the 18 distal anastomoses were occluded (patency rate, 77.8%). There was no significant difference in graft flow or device size when comparing patients with patent vein grafts and those with stenotic or occluded vein grafts. CONCLUSION: Intermediate outcomes of vein grafting using the aortic connector were suboptimal. Long-term outcome data are forthcoming. 相似文献
5.
6.
7.
Yoshiji Asaoka Tokuma Yanai Haruko Hirayama Yumi Une Eriko Saito Hiroki Sakai 《Avian pathology》2004,33(1):19-24
Sporadic outbreaks of fatal enteritis occurred among free-living wild crows (‘large billed’ or ‘wok’ crow; Corvus macrorhynchos) in an open-air park in Japan in 2002. Eight crows were found dead during February, followed by two more in September, and five of the eight were examined histopathologically. At necropsy, all cases showed a markedly dilated small intestine, especially the jejunum and ileum, with large amounts of gas, and dark red to greenish–brown soft content. The necrotic intestinal wall was markedly thickened with multifocal haemorrhages. All cases had multifocal white foci in the liver, and four cases showed marked splenomegaly. Histologically, there was severe necrotic enteritis characterized by extensive mucosal necrosis and multifocal haemorrhages, as well as inflammatory cell infiltrations. A prominent pseudo-membrane formation was noted in the affected intestine. Severe adhesive peritonitis was also observed in three cases. Gram-positive bacilli were present in large numbers in the lumen, and in and around necrotic lesions in the affected intestine. The bacilli were positive for Clostridium perfringens enterotoxin type A by immunohistochemistry, and were also positive for C. perfringens type A using the immunofluorescence method. C. perfringens was isolated by anaerobic culture from the intestinal contents. The present enteritis was thought to be induced by proliferated C. perfringens in the intestine, and to be the cause of death. 相似文献
8.
Kouroku Y Fujita E Jimbo A Kikuchi T Yamagata T Momoi MY Kominami E Kuida K Sakamaki K Yonehara S Momoi T 《Human molecular genetics》2002,11(13):1505-1515
Accumulation of unfolded and malfolded proteins causes endoplasmic reticulum (ER) stress, stimulating unfolded protein response (UPR) and c-Jun N-terminal kinase (JNK) activation and activating caspase-12 located on the ER. Little is known about the relationship between the ER stress and polyglutamine [poly(Q)] aggregates. Poly(Q)72 repeats [poly(Q)(72)] induced the stimulation of ER stress signals such as JNK activation, upregulation of Grp78/Bip and caspase-12 activation in C2C5 cells. We prepared antiserum against the cleavage site of mouse caspase-12 at D(318) (anti-m12D318), and showed that poly(Q)(72) with perinuclear aggregates, cytoplasmic inclusions and nuclear inclusions stimulated JNK activation and anti-m12D318 immunoreactivity, but poly(Q)(72) with dispersed aggregates and small nuclear aggregates showed a significantly less effect. Poly(Q)(72) and poly(Q)(11) dispersed in cytoplasm did not. Anti-m12D318-positive cells showed apoptotic features. Unlike anti-m8D387 immunoreactivity, the anti-m12D318 immunoreactivity was not coaggregated with poly(Q). Ac-IETD-fmk (caspase-8 inhibitor) and Ac-DEVD-CHO (caspase-3 inhibitor) did not prevent the anti-m12D318 immunoreactivity induced by poly(Q)(72) aggregates. Anti-m12D318 immunoreactivity was detected in caspase-8(-/-) and caspase-3(-/-) mouse embryonic fibroblasts expressing poly(Q)(72) aggregates. Thus, caspase-12 was activated by poly(Q)(72) aggregates via a pathway independent of caspase-8 and caspase-3 activation, and caspase-12 activation was closely associated with poly(Q) aggregate-mediated cell death. Stimulation of ER stress signals may be involved in the pathogenesis of neurodegenerative disorders with poly(Q) expansion. 相似文献
9.
10.
T. Yambe S. Nanka S. Naganuma S. Kobayashi S. Nitta T. Fukuju N. Uchida K. Tabayashi A. Tanaka K. Abe H. Takayasu M. Yoshizawa H. Takeda 《Journal of artificial organs》2002,5(1):1-5
Artificial circulation has been analyzed by decomposing it into parts. However, the sum of the decomposed parts is not equal
to the whole system, especially in nonlinear dynamic systems such as biological systems. To evaluate prosthetic circulation
as an entity, not as decomposed parts, nonlinear mathematical analytic techniques, including fractal dimension analyzing theory,
were used. Two pneumatically actuated ventricular assist devices were implanted as biventricular bypasses (BVB) in chronic
animal experiments using four healthy adult goats. For comparison between natural and prosthetic circulation in the same experimental
animals, the BVB-type complete prosthetic circulation model with ventricular fibrillation was adopted. All hemodynamic parameters
with natural and prosthetic circulation were recorded under awake conditions and calculated by a personal computer system.
By the use of nonlinear mathematical techniques, time-series data of the hemodynamics were embedded into the phase space,
and correlation dimension analysis was performed to evaluate the reconstructed attractor. Our results suggest that the correlation
dimension of the arterial blood pressure does not linearly increase according to the increase of the embedding dimension,
even during artificial circulation, suggesting those are the fractal time series data. Dimensional analysis of the hemodynamics
revealed that lower dimensional fractal dynamics were observed during prosthetic circulation. Fractal time series data are
suggested to have robustness and error resistance. Thus, our results suggest that the circulatory regulatory system with the
artificial heart may have these desirable characteristics.
Accepted: July 14, 1995 相似文献