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1.
Nasal transit time in normal subjects and pathologic conditions 总被引:2,自引:0,他引:2
A radionuclide method using Tc-99m was used to measure the nasal transit time in 43 patients, including normal smokers and nonsmokers and those with various nasal or paranasal pathologies. The technique described was slightly modified from that already in use in various centers in order to enable more precise measurement. Measurement of transit time of a droplet of Tc-99m phytate on the nasal mucosa appears to differentiate patients with immotile cilia syndrome from normal controls. A positive test, however, can occur also in smokers and in patients with other nasal and paranasal problems. The test is reproducible, cost-effective, and noninvasive, enabling the clinician to make a more appropriate selection of patients needing further investigation. 相似文献
2.
M Aickin C A Chapin T J Flood S J Englender G G Caldwell 《International journal of epidemiology》1992,21(4):649-655
Reports of a suspected cluster of childhood leukaemia cases in West Central Phoenix have led to a number of epidemiological studies in the geographical area. We report here on a death certificate-based mortality study, which indicated an elevated rate ratio of 1.95 during 1966-1986, using the remainder of the Phoenix standard metropolitan statistical area (SMSA) as a comparison region. In the process of analysing the data from this study, a methodology for dealing with denominator variability in a standardized mortality ratio was developed using a simple linear Poisson model. This new approach is seen as being of general use in the analysis of standardized rate ratios (SRR), as well as being particularly appropriate for cluster investigations. 相似文献
3.
Moshe Harell Moshe Englender Robert Kimhi Myriam Demer Moshe Zohar 《The Laryngoscope》1986,96(8):908-910
Auditory brain stem responses (ABR) were recorded from 20 schizophrenic patients, of whom ten were medicated and ten were unmedicated. A matched control group consisted of ten normal subjects. A statistically significant difference in the latencies of N3 and N5 recordings was found among the three groups. The results suggest that unmedicated schizophrenics have a delayed latency for peaks N3 and N5, and that medication (with neuroleptic drugs) shortens these delayed latencies back to the normal range. 相似文献
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5.
J. Englender J. P. Beregi D. Fayoux R. Astier J. Perennec A. Antonetti Y. Lecarpentier 《Lasers in medical science》1992,7(1-4):467-476
Using a new Q-switched Nd-YAG laser prototype (1064 nm), every initial pulse (15 ns or 33 ns duration, 10 Hz repetition rate,
2×E energy, Pmax power) was transformed into two successive pulses (each one with 15 or 33 ns duration, 1×E energy) delayed
by 27 ns. With a 15 ns initial pulse, the two 15 ns components (each one with Pmax/2) were well separated and called a 15
ns double pulse. When the duration of the initial pulse was stretched to 33 ns, the overlapping of the two 33ns components
(each with Pmax/4) produced only one pulse trapezoidally shaped, of 60 ns duration and called 60 bi-pulse. With double pulses,
it was possible to transmit 100 mJ through a silica-silica optical fibre of 400 μm diameter, whereas 155 mJ were transmitted
with bi-pulses. Human calcified atheromatous tissues were irradiated with bi-pulses through a 200 μm diameter optical fibre.
Craters (0.6–0.7 mm in diameter) were easily obtained in atheromatous aortic segment with 40 mJ energy per bi-pulse. No trace
of carbonization was noticed. Fragmentation of urinary and biliary calculi was also obtained. 相似文献
6.
Type 2A von Willebrand disease (vWD), the most common qualitative form of vWD, is characterized by a relative decrease in circulating intermediate and high molecular weight (HMW) multimers. We studied the biosynthesis of recombinant von Willebrand factor (vWF) containing each of two type 2A vWD mutations previously reported by us, Arg834Gln and Val902Glu. The structure of recombinant Arg834Gln vWF within transfected COS-7 cells and the secretion of HMW multimers were similar to wild type vWF. The normal transport and secretion of Arg834Gln vWF, categorizes it as a group II type 2A mutation. In contrast, the Val90- 2Glu mutation resulted in intracellular proteolysis of vWF with the generation of a 176-kD fragment and retention of vWF between the endoplasmic reticulum and the Golgi complex. Moreover, the 176-kD fragment was also increased in plasma from patients with the Val902Glu mutation. Significantly impaired secretion and intracellular proteolysis of Val902Glu vWF categorizes a new sub-group of type 2A mutations. The intracellular proteolysis of vWF Val902Glu explains the lack of response to 1-deamino 8-D-arginine vasopressin (DDAVP) in patients who carry the mutation. 相似文献
7.
D Hirano G A Gellert K Fleming D Boyd S J Englender H Hawks 《American journal of public health》1994,84(12):2008-2010
The purpose of this study was to evaluate the impact of anonymous testing availability on human immunodeficiency virus (HIV) test demand in Arizona. Testing patterns before and after the introduction of anonymous testing were compared. Client knowledge of new test policy and delay in testing until an anonymous option was available were assessed. Test numbers among men who have sex with men showed a statistically significant increase after introduction of an anonymous testing option. Arizona continues to maintain anonymous testing availability. Public health agencies should consider how test policy may influence people's HIV test decisions. 相似文献
8.
Oded Szold Ron Ben-Abraham Avi A. Weinbroum Talma E. Englender Dror Ovadia Marc Sorkine Cassian Bon Ron Flaison Patrick Sorkine 《Intensive care medicine》2001,27(5):884-888
OBJECTIVES: Tumor necrosis factor (TNF) has been reported as a mediator of local tissue injury following snake envenomation in an intact rat model. We investigated whether systemic release of TNF occurs following Vipera aspis envenomation. We further analyzed the possible connection between envenomation-related hemodynamic depression and TNF antagonization (TNF antibodies or soluble TNF receptor). DESIGN: A prospective, randomized, controlled experimental study using a rat model for snake envenomation. SETTINGS: A medical university hospital research laboratory. INTERVENTION: Eighty rats (300-400 g) were divided into four groups (n = 20): control and three experimental groups. Intramuscular injection of V. asis 500 microg/kg was administered to the three experimental groups: venom only (group 1), venom and 40 microg anti-TNF antibodies (group 2), venom and 250 microg soluble TNF receptor (p55-R; group 3). Hemodynamic parameters were monitored up to 4 h following venom injection. MEASUREMENTS AND RESULTS: A significant hemodynamic deterioration (reduction in heart rate and blood pressure) occurred 30 min following venom injection in group 1 compared to groups 2 and 3, where hemodynamic parameters remained stable throughout the 4 h observation period. Serum levels of TNF were detected 15 min after venom injection and peaked after 2 h at 485+/-12 pg/ml. CONCLUSIONS: The hemodynamic consequences of intramuscular injection of V. aspis venom can be blunted in a rat by systemic antagonization of TNF activity prior to venom injection. The poisonous hemodynamic effects of the V. aspis venom might be caused by systemic release of TNF. 相似文献
9.
4 beta-Phorbol-12-myristate-13-acetate (PMA) at 100 ng/ml was able to induce platelet aggregation in the presence of agents which inhibited aggregation, triggered by other agonists such as adenosine diphosphate sodium salt (ADP), thrombin and collagen. PMA induced aggregation in acid-citrate-dextrose platelet-rich plasma. 100 microM tetracaine, 5 microM bromophenacyl bromide and 0.2 mM mepacrine decreased PMA-induced aggregation by only 10% in contrast to their high inhibitory effect on other aggregation systems. However, 0.4 mM mepacrine did inhibit PMA-induced aggregation at the same rate as the other aggregation systems. 100 mg/ml vincristine slightly affected PMA-induced platelet aggregation, whereas cytochalasin B rather enhanced it. Nordihydroguaiaretic acid, 5, 8, 11, 14-eicosatetraynoic acid and p-nitrophenyl-phosphorylcholine had no effect on PMA- or collagen-induced platelet aggregation, partially inhibited aggregation triggered by ADP and strongly inhibited aggregation caused by thrombin. It is suggested that PMA exerts its effect on platelets mainly due to its ability to alter their membranes. 相似文献
10.
Claire Dossier Anne-Laure Sellier-Leclerc Alexandra Rousseau Yanne Michel Agnès Gautheret-Dejean Mariana Englender Fouad Madhi Marina Charbit Tim Ulinski Tabassome Simon Evelyne Jacqz-Aigrain Georges Deschênes 《Pediatric nephrology (Berlin, Germany)》2014,29(12):2325-2331