全文获取类型
收费全文 | 7544篇 |
免费 | 456篇 |
国内免费 | 55篇 |
专业分类
耳鼻咽喉 | 93篇 |
儿科学 | 180篇 |
妇产科学 | 249篇 |
基础医学 | 984篇 |
口腔科学 | 112篇 |
临床医学 | 628篇 |
内科学 | 1965篇 |
皮肤病学 | 197篇 |
神经病学 | 692篇 |
特种医学 | 308篇 |
外科学 | 1124篇 |
综合类 | 37篇 |
一般理论 | 1篇 |
预防医学 | 385篇 |
眼科学 | 104篇 |
药学 | 444篇 |
中国医学 | 2篇 |
肿瘤学 | 550篇 |
出版年
2023年 | 58篇 |
2022年 | 129篇 |
2021年 | 232篇 |
2020年 | 139篇 |
2019年 | 179篇 |
2018年 | 212篇 |
2017年 | 159篇 |
2016年 | 194篇 |
2015年 | 191篇 |
2014年 | 236篇 |
2013年 | 321篇 |
2012年 | 421篇 |
2011年 | 478篇 |
2010年 | 281篇 |
2009年 | 256篇 |
2008年 | 402篇 |
2007年 | 409篇 |
2006年 | 369篇 |
2005年 | 347篇 |
2004年 | 301篇 |
2003年 | 247篇 |
2002年 | 256篇 |
2001年 | 160篇 |
2000年 | 195篇 |
1999年 | 148篇 |
1998年 | 74篇 |
1997年 | 76篇 |
1996年 | 63篇 |
1995年 | 58篇 |
1994年 | 38篇 |
1993年 | 49篇 |
1992年 | 113篇 |
1991年 | 100篇 |
1990年 | 95篇 |
1989年 | 84篇 |
1988年 | 62篇 |
1987年 | 56篇 |
1986年 | 62篇 |
1985年 | 68篇 |
1984年 | 55篇 |
1983年 | 60篇 |
1981年 | 35篇 |
1980年 | 27篇 |
1979年 | 44篇 |
1978年 | 30篇 |
1977年 | 32篇 |
1974年 | 25篇 |
1973年 | 30篇 |
1972年 | 32篇 |
1970年 | 25篇 |
排序方式: 共有8055条查询结果,搜索用时 15 毫秒
1.
A case of Rubinstein‐Taybi syndrome associated with growth hormone deficiency in childhood
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
3.
4.
5.
6.
J M Esteban J A Kuhn B Felder J Y Wong H Battifora J D Beatty P M Wanek J E Shively 《Cancer research》1991,51(14):3802-3806
We have previously shown that the colon carcinoma (LS174T) xenografts that emerged shortly after radioimmunotherapy with 90Y-labeled anti-CEA monoclonal antibody (MAb) ZCE025 lacked significant expression of CEA in comparison with the untreated tumors. The present study was designed to establish if the immunophenotype of the treated tumors was the result of CEA specific therapy and if the effect was permanent. Athymic mice bearing LS174T tumors were treated either with 120 mu Ci of 90Y-ZCE025, an equal dose of 90Y-96.5 (nonspecific MAb), or received no treatment. When the treated tumors grew to approximately 1.5 cm in diameter (6 weeks after therapy), they were resected and aliquoted to be transplanted to other mice, plated in tissue culture, fixed in formalin, and homogenized for CEA quantitation. The procedure was repeated 3 times (a total of 4 months after treatment). The CEA content was evaluated 2 and 6 weeks after therapy and when the tumors were transplanted. We confirmed a 4-fold decrease of CEA in the resurgent tumors 6 weeks after specific 90Y-ZCE025 therapy, which was twice the decrease experienced by the tumors treated with nonspecific 90Y-96.5, indicating substantial and specific killing of CEA-expressing cells. The CEA content slowly but progressively increased with each new pass of the tumor in the mice, reaching approximately one-half the value of the controls at the end of the study. The resurgent tumors were also studied by immunohistochemistry with MAbs detecting different epitopes of CEA, keratin, TAG-72, and epithelial membrane antigen to evaluate possible additional immunophenotypic changes induced by radioimmunotherapy. Only the expression of TAG-72 (recognized by MAb B72.3) increased immediately after therapy, but it returned to the original levels by the end of the study. These results suggest that: (a) specific radioimmunotherapy with 90Y-ZCE025 selectively kills cells that express higher levels of CEA; (b) the immunophenotype of the surviving fraction of the tumor appears to slowly revert to its original form; and (c) other tumor markers unrelated to CEA can also be affected. These observations have important implications for the design of radioimmunotherapy trials. 相似文献
7.
8.
Lucio Lucchin Amleto D’Amicis Maria Gabriella Gentile Nino Carlo Battistini Maria Antonia Fusco Augusta Palmo Maurizio Muscaritoli Franco Contaldo Emanuele Cereda 《Mediterranean journal of nutrition and metabolism》2009,2(3):171-179
Aim and methods Nutrition, unhealthy lifestyles and cancer appear to be strictly related, but few authors have analysed the interest in dietary
information of cancer patients and their families. This survey was conducted in the Veneto area (Italy) to investigate the
concern of cancer patients and their family members about diet as a health tool before and after diagnosis of cancer.
Results Seven hundred and four questionnaires were collected: 380 from cancer patients and 324 from family members of cancer subjects.
Breast cancer (BC) was the most frequent disease for patients (61.8%) as well as families (26.5%). Generally, the importance
of having precise diet information after diagnosis is recognised by 40.3% of patients, with significant differences between
the various types of cancer: gastric and colon/rectum cancer (GCC) patients were more concerned than BC women about precise
information concerning a diet to follow immediately after diagnosis (p = 0.000, ODs = 3.10, CI 1.68–5.71) or during treatments (p = 0.001, ODs = 2.67, CI 1.46–4.89). The nutritional information is supplied to patients in 34% of cases and to relatives
in 30.3%, often from non-medical sources. In total healthcare workers (family doctor, oncologist, surgeon, dietician) represented
the exclusive source of dietary information for 24.9% of patients and 22.9% of family members. Diet after diagnosis changes
in 69.1% of GCC patients and in 39.2% of BC women. Relatives, particularly women, report difficulties preparing patients’
meals in 30.7% of cases, changes in the eating habits of the entire family in 29.9% and discontent connected with patients
diet in 13.9%. The concern about proper nutrition after diagnosis increases more in GCC subjects (p < 0.025) when compared to BC subjects and in patients with more recent diagnosis (p < 0.041) when compared with patients with diagnosis >5 years ago, while in family members the interest in diet after diagnosis
increases more in women than in men (p < 0.030) without other differences regarding the degree of relationship, type of cancer or diagnosis time. Relatives (92.7%)
have more interest in nutritional education than patients (74.9%). Cancer patients <65 years were more interested in educational
initiatives concerning nutrition (p = 0.000, ODs = 4.46, CI 2.6–7.4) than older patients (>65 years) and female subjects were more concerned than male patients
(p = 0.008, ODs = 2.11, CI 1.2–3.6).
Conclusions The interest in the dietary knowledge and in educational initiatives concerning nutrition is high in cancer patients and their
relatives, although it decreases with the age. The poor attention paid to nutrition of cancer patients by various healthcare
workers deserves consideration, since the psychophysical wellbeing and perhaps also survival of cancer patients can be improved
by correct dietary management, as well as, naturally, by the principal treatments themselves. 相似文献
9.
D S Rao R Antonelli K R Kane J E Kuhn C Hetnal 《Henry Ford Hospital medical journal》1991,39(1):41-44
Coexistent primary hyperparathyroidism and monoclonal gammopathy, although rare, has been reported previously by a number of investigators. We report four patients with such an occurrence who were seen between 1976 and 1988. Another patient with primary hyperparathyroidism also had multiple myeloma and was in remission for 12 years. These patients represent approximately 1% of the 386 patients with primary hyperparathyroidism seen during the same 12-year period. Although several mechanisms have been proposed to explain this concurrence, we believe it is the result of a chance occurrence. A review of the literature, an estimate of the chance occurrence of coincidental monoclonal gammopathy, benign or malignant, in patients with primary hyperparathyroidism, and some practical implications of this interesting coexistence are presented. 相似文献
10.
Dr. med. H. Kuhn Dr. med. R. Gerdes-Kuhn Prof. Dr. med. H.-H. Küster 《Fu? & Sprunggelenk》2007,5(1):26-31
The Cinderella shoe syndrome specifies a commonly observed, not yet labeled disproportion of footwear and the morphologic conditions of the wearer. Disproportioned shoes and socks are worn–frequently unconsciously–due to personal reasons, fashion trends, misinformation and wrong advice; they can induce severe foot disorders. The Cinderella shoe syndrome has an important significance within the development, the treatment and the recurrence-prophylaxis of foot disorders, as well as in the assessment of possible reasons for recurrence after foot surgery. To recognize it, to treat individual psychologic reasons, to give support in the choice of footwear, to inform about and to change social reasons are all challenges of the foot surgeon. 相似文献