全文获取类型
收费全文 | 1117篇 |
免费 | 81篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 29篇 |
妇产科学 | 16篇 |
基础医学 | 228篇 |
口腔科学 | 9篇 |
临床医学 | 116篇 |
内科学 | 244篇 |
皮肤病学 | 31篇 |
神经病学 | 134篇 |
特种医学 | 28篇 |
外科学 | 80篇 |
综合类 | 1篇 |
预防医学 | 83篇 |
眼科学 | 14篇 |
药学 | 96篇 |
中国医学 | 2篇 |
肿瘤学 | 87篇 |
出版年
2024年 | 5篇 |
2023年 | 23篇 |
2022年 | 29篇 |
2021年 | 69篇 |
2020年 | 39篇 |
2019年 | 63篇 |
2018年 | 57篇 |
2017年 | 38篇 |
2016年 | 45篇 |
2015年 | 56篇 |
2014年 | 64篇 |
2013年 | 61篇 |
2012年 | 120篇 |
2011年 | 127篇 |
2010年 | 72篇 |
2009年 | 45篇 |
2008年 | 72篇 |
2007年 | 51篇 |
2006年 | 39篇 |
2005年 | 43篇 |
2004年 | 26篇 |
2003年 | 23篇 |
2002年 | 28篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
排序方式: 共有1202条查询结果,搜索用时 62 毫秒
1.
2.
Marion Imbert-Bouteille Frédéric Tran Mau Them Julien Thevenon Thomas Guignard Vincent Gatinois Jean-Baptiste Riviere Anne Boland Vincent Meyer Jean-François Deleuze Elodie Sanchez Florence Apparailly David Geneviève Marjolaine Willems 《European journal of medical genetics》2019,62(3):161-166
Alazami syndrome (AS) (MIM# 615071) is an autosomal recessive microcephalic primordial dwarfism (PD) with recognizable facial features and severe intellectual disability due to depletion or loss of function variants in LARP7. To date, 15 patients with AS have been reported. Here we describe two consanguineous Algerian sisters with Alazami PD due to LARP7 homozygous pathogenic variants detected by whole exome sequencing. By comparing these two additional cases with those previously reported, we strengthen the key features of AS: severe growth restriction, severe intellectual disability and some distinguishing facial features such as broad nose, malar hypoplasia, wide mouth, full lips and abnormally set teeth. We also report significant new findings enabling further delineation of this syndrome: disproportionately mild microcephaly, stereotypic hand wringing and severe anxiety, thickened skin over the hands and feet, and skeletal, eye and heart malformations. From previous reviews, we summarize the main etiologies of PD according to the involved mechanisms and cellular pathways, highlighting their clinical core features. 相似文献
3.
Philippe Hup Cline Rouveirol Isabel Brito Pierre Neuvial Philippe La Rosa Eric Viara Nicolas Stransky Gaëlle Pierron Elodie Mani Caroline Brennetot Isabelle Jannoueix Nadge Gruel Alain Aurias Olivier Delattre Franois Radvanyi Emmanuel Barillot 《European journal of medical genetics》2005,48(4):467-468
4.
Elodie Mordelet Heather A Davies Philippa Hillyer Ignacio A Romero David Male 《Endothelium》2007,14(1):7-15
Leukocyte migration across vascular endothelium is mediated by chemokines that are either synthesized by the endothelium or transferred across the endothelium from the tissue. The mechanism of transfer of two chemokines, CXCL10 (interferon gamma-inducible protein [IP]-10) and CCL2 (macrophage chemotactic protein [MCP]-1), was compared across dermal and lung microvessel endothelium and saphenous vein endothelium. The rate of transfer depended on both the type of endothelium and the chemokine. The permeability coefficient (Pe) for CCL2 movement across saphenous vein was twice the value for dermal endothelium and four times that for lung endothelium. In contrast, the Pe value for CXCL10 was lower for saphenous vein endothelium than the other endothelia. The differences in transfer rate between endothelia was not related to variation in paracellular permeability using a paracellular tracer, inulin, and immunoelectron microscopy showed that CXCL10 was transferred from the basal membrane in a vesicular compartment, before distribution to the apical membrane. Although all three endothelia expressed high levels of the receptor for CXCL10 (CXCR3), the transfer was not readily saturable and did not appear to be receptor dependent. After 30 min, the chemokine started to be reinternalized from the apical membrane in clathrin-coated vesicles. The data suggest a model for chemokine transcytosis, with a separate pathway for clearance of the apical surface. 相似文献
5.
Pagot E Fiedler S Cloetens P Bravin A Coan P Fezzaa K Baruchel J Härtwig J von Smitten K Leidenius M Karjalainen-Lindsberg ML Keyriläinen J 《Physics in medicine and biology》2005,50(4):709-724
Two x-ray phase contrast imaging techniques are compared in a quantitative way for future mammographic applications: diffraction enhanced imaging (DEI) and phase propagation imaging (PPI). DEI involves, downstream of the sample, an analyser crystal acting as an angular filter for x-rays refracted by the sample. PPI simply uses the propagation (Fresnel diffraction) of the monochromatic and partially coherent x-ray beam over large distances. The information given by the two techniques is assessed by theoretical simulations and compared at the level of the experimental results for different kinds of samples (phantoms and real tissues). The imaging parameters such as the energy, the angular position of the analyser crystal in the DEI case or the sample to detector distance in the PPI case were varied in order to optimize the image quality in terms of contrast, visibility and figure of merit. 相似文献
6.
Mathilde Chataigner Marie Martin Cline Lucas Veronique Pallet Sophie Lay Alexis Mehaignerie Elodie Bouvret Anne-Laure Dinel Corinne Joffre 《Nutrients》2021,13(3)
Neuroinflammation constitutes a normal part of the brain immune response orchestrated by microglial cells. However, a sustained and uncontrolled production of proinflammatory factors together with microglial activation contribute to the onset of a chronic low-grade inflammation, leading to neuronal damage and cognitive as well as behavioral impairments. Hence, limiting brain inflammatory response and improving the resolution of inflammation could be particularly of interest to prevent these alterations. Dietary n-3 long chain polyunsaturated fatty acids (LC-PUFAs) and low molecular weight peptides are good candidates because of their immunomodulatory and proresolutive properties. These compounds are present in a fish hydrolysate derived from marine-derived byproducts. In this study, we compared the effect of an 18-day supplementation with this fish hydrolysate to a supplementation with docosahexaenoic acid (DHA) on lipopolysaccharide (LPS)-induced inflammation in mice. In response to peripherally injected LPS, the fish hydrolysate supplementation decreased the hippocampal mRNA expression of the proinflammatory cytokines IL-6 (p < 0.001), IL-1β (p = 0.0008) and TNF-α (p < 0.0001), whereas the DHA supplementation reduced only the expression of IL-6 (p = 0.004). This decline in proinflammatory cytokine expressions was associated with an increase in the protein expression of IκB (p = 0.014 and p = 0.0054 as compared to the DHA supplementation and control groups, respectively) and to a modulation of microglial activation markers in the hippocampus. The beneficial effects of the fish hydrolysate could be due in part to the switch of the hippocampal oxylipin profile towards a more anti-inflammatory profile as compared to the DHA supplementation. Thus, the valorization of fish byproducts seems very attractive to prevent and counteract neuroinflammation. 相似文献
7.
Alice Nourissat MD Isabelle Bairati MD PhD Elodie Samson MSc André Fortin MD MSc Michel Gélinas MD Abdenour Nabid MD François Brochet MD Bernard Têtu MD François Meyer MD DSc 《Cancer》2010,116(9):2275-2283
BACKGROUND:
The purpose of the study was to identify predictors of weight loss during radiotherapy (RT) in patients with stage I or II head and neck (HN) cancer.METHODS:
This study was conducted as part of a phase 3 chemoprevention trial. A total of 540 patients were randomized. The patients were weighed before and after RT. Their baseline characteristics, including lifestyle habits, diet, and quality of life, were assessed as potential predictors. Predictors were identified using multiple linear regressions. The reliability of the model was assessed by bootstrap resampling. A receiver operating characteristics curve was generated to estimate the model's accuracy in predicting critical weight loss (≥5%).RESULTS:
The mean weight loss was 2.2 kg (standard deviation, 3.4). Five factors were associated with a greater weight loss: all HN cancer sites other than the glottic larynx (P<.001), higher pre‐RT body weight (P<.001), stage II disease (P = .002), dysphagia and/or odynophagia before RT (P = .001), and a lower Karnofsky performance score (P = .028). There was no association with pre‐RT lifestyle habits, diet, or quality of life. The bootstrapping method confirmed the reliability of this predictive model. The area under the curve was 71.3% (95% confidence interval, 65.8‐76.9), which represents an acceptable ability of the model to predict critical weight loss.CONCLUSIONS:
These results could be useful to clinicians for screening patients with early stage HN cancer treated by RT who require special nutritional attention. Cancer 2010. © 2010 American Cancer Society. 相似文献8.
Arnaud Scherpereel Julien Mazieres Laurent Greillier Sylvie Lantuejoul Pascal Dô Olivier Bylicki Isabelle Monnet Romain Corre Clarisse Audigier-Valette Myriam Locatelli-Sanchez Olivier Molinier Florian Guisier Thierry Urban Catherine Ligeza-Poisson David Planchard Elodie Amour Franck Morin Denis Moro-Sibilot Delphine CARMIER 《The lancet oncology》2019,20(2):239-253
9.