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排序方式: 共有143条查询结果,搜索用时 15 毫秒
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Emily M. Grundy Cecilia Albala Elizabeth Allen Alan D. Dangour Diana Elbourne Ricardo Uauy 《Aging & mental health》2012,16(8):1047-1057
Objectives: To investigate factors associated with Chilean grandparents’ provision of help to grandchildren and associations between provision of such help and grandparents’ mental well-being two years later. Methods: Data are drawn from a representative sample of 2000 people aged 66–68 resident in low- or middle-income areas of Santiago who were surveyed in 2005 and re-interviewed two years later. Multivariable analyses were used to investigate factors associated with provision of help to grandchildren at baseline and associations between providing such help and life satisfaction, SF36-Mental Component Summary scores, and depression two years later. Results: 41% of grandparents lived with one or more grandchildren and over half provided four or more hours per week of help to grandchildren. Models controlling for baseline mental health, grandchild characteristics, marital and household characteristics, socio-economic status and functional health showed that grandfathers who provided four or more hours per week of help to grandchildren had better life satisfaction two years later and that those providing material help had higher SF36 MCS scores at follow-up. Grandmothers providing four or more hours of help a week had lower risks of depression. Conclusion: Older Chileans make important contributions to their families through the provision of help to grandchildren and these appear to have some benefits for their own psychosocial health. Gender differences in the pattern of associations may reflect differences in overall family responsibilities and merit further investigation. 相似文献
3.
Background: The Magpie Trial compared magnesium sulfate with placebo for women with preeclampsia. The objective of this study was to explore women's views and experiences of participating in the Magpie Trial in the United Kingdom. Methods: Postal questionnaires were sent to 771 women participants in the Magpie Trial to assess long‐term health of UK women and children. The questionnaire included three questions exploring women's experience of participating in the trial: (a) If time suddenly went backward, and you had to do it all over again, would you agree to participate in the Magpie Trial? (b) Please tell us if there was anything about the Magpie Trial that you think could have been done better; and (c) Please tell us if there was anything about the Magpie Trial, or your experience of joining the trial, that you think was particularly good. Results: Overall, 619 of the 771 women who were sent questionnaires returned them. In response to the three questions: (a) 58 percent (356) of women responded “definitely yes,” 27 percent (169) “probably yes,” 4 percent (23) “probably no,” 5 percent (33) “definitely no,” and 5 percent (34) “not sure.” No clear evidence was shown of a relationship with allocated treatment, although women who responded “probably or definitely no” were more likely to have had side effects from trial treatment. (b) Although 44 percent of women stated that nothing could have been done better, free text suggestions related to content of recruitment information, and its timing, and wanting to know treatment allocation and trial results. c) Women were generally extremely positive about being followed up and receiving trial results. Conclusions: Women were largely positive about participation in the trial and its follow‐up, but still reported ways they believed the study could have been improved, such as more information, given earlier, which also has implications for clinical care. 相似文献
4.
Gray A Elbourne D Dezateux C King A Quinn A Gardner F 《The Journal of bone and joint surgery. American volume》2005,87(11):2472-2479
BACKGROUND: Clinical neonatal hip screening is performed to identify hip instability and the increased risk of later hip subluxation and dislocation. However, there is minimal information regarding the costs of such screening to parents and health services. The aim of this study was to assess these costs in association with the use of ultrasonography for the diagnosis and management of neonatal hip instability. METHODS: We conducted a prospective economic analysis in conjunction with a randomized clinical trial (the Hip Trial), for which 629 patients were recruited from thirty-three centers in the United Kingdom and Ireland to be randomized to undergo either ultrasonographic hip examination (314 patients) or clinical assessment alone (315 patients). Information on clinical outcomes was obtained from hospital records and records from the Hip Trial. Resource information was obtained from hospital records and from repeated periodic cross-sectional surveys of the families. Typical unit costs were applied to resource information to obtain a cost per patient, and the mean costs in the two study groups were calculated and compared. RESULTS: The average overall health-service cost per patient (and standard deviation) was $1298 +/- $2168 in the ultrasonography group and $1488 +/- $2912 in the group that underwent clinical assessment alone, a net difference of -$190 (95% confidence interval, -$630 to $250). Families in which the infant was examined with ultrasonography had significantly lower costs associated with splinting: $92 compared with $118 in the group that underwent clinical assessment alone, a mean difference of -$26 (95% confidence interval, -$46 to -$6). Costs associated with surgery and total costs to the family were also slightly, but not significantly, lower in the ultrasonography group. CONCLUSIONS: Our results suggest that use of ultrasonography in the management of neonates with clinical hip instability is unlikely to impose an increased cost burden and may reduce costs to health services and families. 相似文献
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6.
Perinatal pathology in the context of a clinical trial: attitudes of neonatologists and pathologists 总被引:1,自引:0,他引:1
Snowdon C Elbourne DR Garcia J 《Archives of disease in childhood. Fetal and neonatal edition》2004,89(3):F204-F207
OBJECTIVE: To describe the attitudes of neonatologists to trial related perinatal postmortem examinations (PMs), in the light of declining perinatal PM rates and poor levels of participation in pathology studies. METHODS: A qualitative study was carried out, using semistructured interviews. Twenty six neonatologists from five UK neonatal units were interviewed; five UK perinatal pathologists also contributed to the study. The professionals involved were all linked to one or both of two neonatal trials. RESULTS: Pathologists expressed concern over the difficulties experienced in UK perinatal pathology and the impact on research of inadequate levels of samples. The interviews with neonatologists reveal discomfort over approaching bereaved parents for PMs, and a widespread concern that parents should not be further distressed or feel under pressure to consent. Although there was support for neonatal trials, the study highlights a view that PMs may be unnecessary if the cause of death seems apparent or when a baby was born prematurely, and a devaluation of PMs among some younger staff. Poor rates of participation in pathology studies may be accounted for by a notable sense of disconnection between trial interventions and pathology studies. CONCLUSIONS: Neonatologists were concerned to protect vulnerable parents and varied in whether they saw this as compatible with inclusion in trial related pathology studies. Dedicated research is needed to document and gain an understanding of the consent process and should examine the usefulness and impact of consent forms. It should assess whether professionals might benefit from training, to help parents to come to their decisions. 相似文献
7.
Elbourne D Ayers S Dellagrammaticas H Johnson A Leloup M Lenoir-Piat S;EC Ethamsylate Trial Group 《Archives of disease in childhood. Fetal and neonatal edition》2001,84(3):F183-F187
AIM: To assess the role of etamsylate in reducing the risk of haemorrhagic brain damage and its consequences. DESIGN: Follow up of babies recruited into a randomised controlled trial. METHODS: A total of 334 infants born before 33 weeks gestation in France and Greece were randomly allocated within the first four hours of birth either to receive etamsylate or to act as controls. The principal outcomes in the trial were death or impairment and/or disability at the age of 2 years. RESULTS: Fifty nine children were lost to follow up. A total of 115 (34%) either died or had some impairment or disability, and 88 (26%) either died or had severe impairment or disability at 2 years of age. These outcomes did not differ significantly between the two randomised groups: relative risks and 95% confidence intervals 1.14 (0.78 to 1.4) and 1.17 (0.82 to 1.68) respectively. The findings were similar for all the prespecified subgroup analyses stratified by key prognostic factors at trial entry: country of birth, gestational age < or >or= 29 weeks, inborn or outborn, age < or >or= 1 hour, and with or without cerebral scan abnormality. CONCLUSION: These findings do not support the use of etamsylate. Other strategies need to be evaluated for the prevention of mortality and morbidity in these vulnerable infants. 相似文献
8.
9.
A. D. Dangour E. Allen D. Elbourne A. Fletcher M. Richards R. Uauy 《The journal of nutrition, health & aging》2009,13(3):198-202
Background Observational epidemiological data suggest that habitual consumption in later life of oily fish, rich in n-3 long-chain polyunsaturated
fatty acids (n-3 LCPs), is associated with better cognitive function, slower rates of cognitive decline and a lower risk of
dementia. In this paper we present data on baseline fish consumption and cognitive function in cognitively healthy older people
randomised onto the Older People And n-3 Long-chain polyunsaturated fatty acid (OPAL) study.
Methods In total, 867 older people were recruited to join the OPAL study from 20 general practices in England and Wales. Participants
were aged 70–79 years at baseline were free of dementia and diabetes, had a Mini-Mental State Examination score of 24 or greater
and did not report daily fish oil supplement consumption. Self-reported habitual fish consumption was assessed at baseline
via questions on frequency and type of fish consumption. Cognitive function at baseline was assessed via validated cognitive
tests assessing memory, executive function, psychomotor speed and attention, including the Californian Verbal Learning Test
(CVLT), the primary outcome of the OPAL study. Reported age at leaving full time education was recorded as a measure of educational
achievement and psychological health was measured using the GHQ-30 questionnaire.
Results Unadjusted analysis revealed significant positive associations between reported fish consumption and the CVLT scores with
a mean increase of approximately 0.24 words remembered for each increase in level of reported fish consumption. These associations
were noticeably attenuated on adjustment for age, gender and reported age at leaving full-time education and did not remain
significant on further adjustment for GHQ-30 score. Similar associations were also observed between fish consumption and the
global cognitive z-score, memory score, executive function score and delay scores in unadjusted analysis with the associations
again attenuated on adjustment.
Conclusions Baseline data from participants randomised into the OPAL study provide support for the hypothesis that higher fish consumption
is associated with better cognitive function in later life. However, although in the main associations remain after adjusting
for education and psychological health, the data do not allow us to rule out the possibility of residual confounding e.g.
from socioeconomic status or other health behaviours. Evidence is needed from randomised clinical trials to clarify the role
of n-3 LCPs in cognitive health in later life in the normal older person population. 相似文献
10.
F. M. Fairlie Consultant Obstetrician Gynaecologist L. Marshall Labour Ward Sister/Midwife J. J. Walker Professor D. Elbourne Senior Lecturer 《BJOG : an international journal of obstetrics and gynaecology》1999,106(11):1181-1187
Objective To compare the pain relief and side effects of intramuscular pethidine with intramuscular diamorphine in labour.
Design Double-blind randomised controlled trial.
Setting The labour ward in a UK teaching hospital.
Participants Sixty-nine nulliparous women and 64 multiparous women in labour who requested narcotic analgesia and remained undelivered one hour after trial entry.
Methods Nulliparous women were randomised to receive either 150 mg intramuscular pethidine or 7–5 mg intramuscular diamorphine. Multiparous women were randomised to receive either 100 mg intramuscular pethidine or 5 mg intramuscular diamorphine. All participants received the anti-emetic prochloroperazine at the same time as the trial drugs.
Main outcome measures Maternal analgesia assessed by a visual analogue score and verbal scales of pain intensity and pain relief, maternal sedation and vomiting, neonatal outcome assessed by Apgar scores and the need for resuscitation.
Results More women allocated to receiving pethidine than to diamorphine reported slight or no pain relief at 60 minutes after administration of these drugs ( P = 0.03 ). This trend was repeated in most of the other measures for maternal analgesia. There was no difference in maternal sedation, but the incidence of vomiting within 60 minutes was lower for women who received diamorphine ( P = 0.02 ). Pethidine was associated with lower Apgar scores at 1 minute ( P < 0.05 ).
Conclusion Intramuscular diamorphine in labour appears to have some benefits, compared with intramuscular pethidine, but the trial was small and further research, particularly into alternative opioids and long term effects on the infants is still needed. 相似文献
Design Double-blind randomised controlled trial.
Setting The labour ward in a UK teaching hospital.
Participants Sixty-nine nulliparous women and 64 multiparous women in labour who requested narcotic analgesia and remained undelivered one hour after trial entry.
Methods Nulliparous women were randomised to receive either 150 mg intramuscular pethidine or 7–5 mg intramuscular diamorphine. Multiparous women were randomised to receive either 100 mg intramuscular pethidine or 5 mg intramuscular diamorphine. All participants received the anti-emetic prochloroperazine at the same time as the trial drugs.
Main outcome measures Maternal analgesia assessed by a visual analogue score and verbal scales of pain intensity and pain relief, maternal sedation and vomiting, neonatal outcome assessed by Apgar scores and the need for resuscitation.
Results More women allocated to receiving pethidine than to diamorphine reported slight or no pain relief at 60 minutes after administration of these drugs ( P = 0.03 ). This trend was repeated in most of the other measures for maternal analgesia. There was no difference in maternal sedation, but the incidence of vomiting within 60 minutes was lower for women who received diamorphine ( P = 0.02 ). Pethidine was associated with lower Apgar scores at 1 minute ( P < 0.05 ).
Conclusion Intramuscular diamorphine in labour appears to have some benefits, compared with intramuscular pethidine, but the trial was small and further research, particularly into alternative opioids and long term effects on the infants is still needed. 相似文献