全文获取类型
收费全文 | 281篇 |
免费 | 8篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 1篇 |
基础医学 | 9篇 |
口腔科学 | 2篇 |
临床医学 | 11篇 |
内科学 | 96篇 |
皮肤病学 | 1篇 |
神经病学 | 7篇 |
特种医学 | 2篇 |
外科学 | 59篇 |
预防医学 | 5篇 |
药学 | 2篇 |
肿瘤学 | 111篇 |
出版年
2024年 | 1篇 |
2023年 | 4篇 |
2022年 | 7篇 |
2021年 | 13篇 |
2020年 | 1篇 |
2019年 | 3篇 |
2018年 | 6篇 |
2017年 | 7篇 |
2016年 | 16篇 |
2015年 | 20篇 |
2014年 | 11篇 |
2013年 | 13篇 |
2012年 | 30篇 |
2011年 | 37篇 |
2010年 | 20篇 |
2009年 | 11篇 |
2008年 | 8篇 |
2007年 | 13篇 |
2006年 | 7篇 |
2005年 | 9篇 |
2004年 | 20篇 |
2003年 | 13篇 |
2002年 | 9篇 |
2001年 | 3篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1988年 | 5篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有310条查询结果,搜索用时 31 毫秒
1.
Eigo Otsuji Toshiharu Yamaguchi Nozomi Yamaguchi Kunihiko Koyama Jiro Imanishi Nobuki Yamaoka Toshio Takahashi 《Surgery today》1992,22(4):351-356
In a previous study, we used a murine monoclonal antibody, A7, against human colon carcinoma as a drug-carrier to treat colorectal cancer.1 In the present study, we found that MAb A7 also reacted immunohistochemically with 73% of human pancreatic carcinoma cell lines, with the A7 antigen mainly being detected on the cell surface. However, the A7 antigen was found in only 9% of the spent media of these human pancreatic carcinoma cell lines by ELISA. On the other hand, the positive incidence of CA19-9, POA, ferritin, CEA, DU-PAN-2 and SLX in those spent media was 100%, 64%, 64%, 55%, 55% and 36%, respectively. These results suggest that the A7 antigen may only rarely be shed into the sera of pancreatic cancer patients, in which case MAb A7 could be a suitable drug-carrier in targeting chemotherapy for pancreatic cancer patients. 相似文献
2.
Evaluation of nicotine,cotinine, thiocyanate,carboxyhemoglobin, and expired carbon monoxide as biochemical tobacco smoke uptake parameters 总被引:2,自引:0,他引:2
Hideo Muranaka Eigo Higashi Shunro Itani Yoshiharu Shimizu 《International archives of occupational and environmental health》1988,60(1):37-41
Summary In a cross-sectional study on 236 individuals in Japan (174 males, 62 females; 149 smokers, 87 non-smokers) plasma nicotine (pnic), cotinine (pcot) and thiocyanate (pSCN), urinary creatinine ratios of nicotine (unic), cotinine (ucot) and thiocyanate (uSCN) as well as carboxyhemoglobin (COHb) and expired carbon monoxide (COex) were determined. All tobacco smoke uptake parameters (TSUP) were significantly elevated in smokers as compared to non-smokers. The discriminant power (smokers vs non-smokers) rank in the following order: ucot pcot unic > pSCN COHb pnic > COex uSCN. All parameters except for pnic are significantly correlated with the self-reported number of cigarettes smoked per day. The reason for the poor correlation of pnic with daily cigarette consumption is the short half-life of pnic coupled with the arbitrary time of blood drawing in relation to the last time of smoking.Dr. Muranaka, the chief author of this paper, was the director of our hospital. He died suddenly on 18 April 1986. This article is therefore the last monument to be planned and achieved under the late Dr. Muranaka's direction. 相似文献
3.
Masahiko Fujita Eigo Takabatake Keiko Tsuchiya 《Archives of environmental contamination and toxicology》1982,11(5):645-649
Experiments were made to observe the effects of the maternal administration of cadmium and zinc and their influence on the metal-binding capacity of metallothionein in the rat fetus. Metallothionein was detected in the fetal liver as early as day 16 of gestation and may have appeared earlier. The zinc concentration in the metallothionein fraction was low on day 16 but increased as gestation progressed. The metal-binding capacity was fairly high on day 16 but increased at a slower rate than the zinc concentration. Following the intraperitoneal administration of zinc (100 moles Zn/kg) or cadmium (5 moles Cd/kg) once a day on days 14, 15 and 16 of gestation to the dam, the concentration of zinc in the metallothionein fraction of the maternal liver was far greater than that in the fetal liver. In contrast, cadmium was found only in the metallothionein fraction of the maternal liver; it was not found in the fetal liver, which suggests an effective placental barrier to cadmium. The metalbinding capacity in the fetal liver was induced by the maternal administration of zinc, but not cadmium. 相似文献
4.
5.
6.
Hiroki Takeshita Daisuke Ichikawa Shuhei Komatsu Takeshi Kubota Kazuma Okamoto Atsushi Shiozaki Hitoshi Fujiwara Eigo Otsuji 《World journal of surgery》2013,37(12):2891-2898
Background
This study was designed to determine the surgical outcomes of gastric cancer in elderly patients. This information can help establish appropriate treatment for these patients.Methods
A total of 1,193 patients with gastric cancer who underwent gastrectomy between 1995 and 2010 were enrolled in this retrospective study. The clinicopathologic features of 104 elderly patients (aged ≥80 years) were compared with those of 1,089 nonelderly patients.Results
(1) Tumors located in the lower-third of the stomach, differentiated cancer, and surgery with limited lymph node dissection were more common in elderly patients. However, there was no difference in the proportion of laparoscopic gastrectomy between elderly and nonelderly patients. (2) Although surgical complication rates were similar in the two groups, the operative mortality rate was higher in elderly patients (1.9 %) than in nonelderly patients (0.7 %). (3) Elderly patients had a significantly poorer overall survival rate, whereas the disease-specific survival rates of the two groups were similar. Limited lymph node dissection did not influence the disease-specific survival rate of elderly patients. (4) The median life expectancy of elderly gastric cancer survivors was 9.8 years in patients aged 80–84 years and 6.0 years in those ≥85 years. The patients with limited lymph node dissection had slightly better prognosis.Conclusions
The treatment results in elderly patients were comparable to those in nonelderly patients. These findings suggest that R0 resection with at least limited lymph node dissection according to Japanese guidelines should be considered, even for elderly patients. 相似文献7.
Shuhei?KomatsuEmail author Daisuke?Ichikawa Mahito?Miyamae Toshiyuki?Kosuga Kazuma?Okamoto Tomohiro?Arita Hirotaka?Konishi Ryo?Morimura Yasutoshi?Murayama Atsushi?Shiozaki Yoshiaki?Kuriu Hisashi?Ikoma Masayoshi?Nakanishi Hitoshi?Fujiwara Eigo?Otsuji 《Journal of gastrointestinal surgery》2016,20(9):1565-1571
Background
Nodal metastasis is an important clinical issue in gastric cancer patients. This study was designed to investigate the clinical usefulness of the positive lymph node ratio (PLNR), which reflects both metastatic and retrieved lymph node numbers, in patients with pN3 gastric cancer.Methods
We retrospectively analyzed the records of 138 consecutive pN3 patients who underwent curative gastrectomy with lymphadenectomy from 2000 to 2012.Results
A PLNR of 0.4 was proved to be the best cutoff value to stratify the prognosis of patients with pN3 gastric cancer (P?<?0.001). Univariate and multivariate analyses revealed that older age, larger tumor size (≥10 cm), and PLNR?≥?0.4 [P?<?0.001, HR 3.1 (95 % CI 1.7–5.4)] were independent prognostic factors in pN3 gastric cancer. Regarding the recurrence, patients with PLNR <0.4 had a significantly lower rate of lymph node recurrence than those with PLNR ≥0.4 (P?=?0.020). There was no significant difference in the lymph node recurrence rate between N3a and N3b patients in the PLNR <0.4 group [P?=?0.546, 11.6 % (7/60) vs. 12.5 (1/8)], indicating a better local control regardless of pN3 subgroups.Conclusions
PLNR is useful to stratify the prognosis and evaluate the extent of local tumor clearance in pN3 gastric cancer.8.
Kato Shunji Shiozaki Atsushi Kudou Michihiro Shimizu Hiroki Kosuga Toshiyuki Ohashi Takuma Arita Tomohiro Konishi Hirotaka Komatsu Shuhei Kubota Takeshi Fujiwara Hitoshi Okamoto Kazuma Kishimoto Mitsuo Konishi Eiichi Otsuji Eigo 《Annals of surgical oncology》2022,29(5):2944-2956
Annals of Surgical Oncology - Transient receptor potential vanilloid 2 (TRPV2) is a highly Ca2+-permeable ion channel that is involved in a number of cellular processes. It is expressed in various... 相似文献
9.
Otsuji E Kuriu Y Ichikawa D Ochiai T Okamoto K Hagiwara A Yamagishi H 《Hepato-gastroenterology》2008,55(82-83):755-759
BACKGROUND/AIMS: Extended lymphadenectomy with gastrectomy is widely performed for patients with advanced gastric carcinoma. However, the therapeutic value of prophylactic extensive lymphadenectomy in patients with node-negative advanced gastric cancer is controversial. METHODOLOGY: We retrospectively analyzed 221 patients who underwent curative gastrectomy for advanced gastric carcinoma without lymph node metastasis to evaluate the effect of prophylactic extended lymphadenectomy on postoperative survival. The postoperative survival rate of patients who underwent extended lymphadenectomy was compared with that of patients who underwent limited lymphadenectomy. Predictive risk factors for tumor recurrence and recurrent patterns also were analyzed. RESULTS: Extended lymphadenectomy improved the postoperative survival rate of patients with advanced tumors even when lymph node spread was absent. Whether or not prophylactic extended lymphadenectomy was performed significantly affected tumor recurrence in patients with node-negative advanced gastric carcinoma. CONCLUSIONS: Extensive lymphadenectomy with gastrectomy prolongs survival of patients with node-negative advanced tumors. 相似文献
10.
Hiroki Shimizu Atsushi Shiozaki Daisuke Ichikawa Hitoshi Fujiwara Hirotaka Konishi Hiromichi Ishii Shuhei Komatsu Takeshi Kubota Kazuma Okamoto Mitsuo Kishimoto Eigo Otsuji 《Journal of gastroenterology》2014,49(4):655-666