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1.
ALBERTO Q FARIAS LUCIANA L GONÇALVES EDUARDO LR CANÇADO ANTONIO C SEGURO SILVIA B CAMPOS CLARICE P ABRANTES-LEMOS FLAIR J CARRILHO 《Journal of gastroenterology and hepatology》2006,20(1):147-152
Background and Aims: Primary biliary cirrhosis (PBC) might be complicated by osteoporosis, whose etiology remains unknown but seems to be multifactorial. Prevalence rates of 30% to 60% for distal renal tubular acidosis (DRTA) have been reported in PBC patients, generally as incomplete DRTA. Although it is undisputed that a reduced bone mineral density (BMD) is the expected outcome among patients who have been suffering from longstanding chronic metabolic acidosis, it is unclear if incomplete DRTA is also associated with metabolic bone disease in PBC patients. The present study was undertaken to compare the BMD of PBC patients with and without DRTA.
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
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MIGUEL Kreisler ANTONIO Arnaiz EENIGNO Perez EDUARDO FERNANDEZ Cruz ALFREDO Bootello 《Tissue antigens》1974,4(2):197-201
HL—A phenotype frequencies were studied in 30 patients with leprosy and in 149 healthy controls. Leprosy patients had a significantly higher frequency of HL—A14. In addition, a majority of the HL—A14 patients gave a negative response to leproma antigen using the Mitsuda test. 相似文献
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EDUARDO ARANA‐RUEDA M.D. Ph.D. ALONSO PEDROTE M.D. Ph.D. LORENA GARCÍA‐RIESCO M.D. ALVARO ARCE‐LEÓN M.D. FEDERICO GÓMEZ‐PULIDO M.D. JUAN‐MANUEL DURÁN‐GUERRERO M.D. AGUSTÍN FERNÁNDEZ‐CISNAL M.D. MANUEL FRUTOS‐LÓPEZ M.D. JUAN‐ANTONIO SÁNCHEZ‐BROTONS M.D. 《Pacing and clinical electrophysiology : PACE》2015,38(2):216-224
8.
JEFFREY H. PLOCHOCKI JOSE R. RODRIGUEZ‐SOSA BRENT ADRIAN SAUL A. RUIZ MARGARET I. HALL 《Clinical anatomy (New York, N.Y.)》2016,29(8):1053-1058
Modern anatomical and surgical references illustrate perineal muscles all innervated by branches of the pudendal nerve but still organized into anatomically distinct urogenital and anal triangles with muscles inserting onto a central perineal body. However, these conflict with the anatomy commonly encountered during dissection. We used dissections of 43 human cadavers to characterize the anatomical organization of the human perineum and compare our findings to standard references. We found bulbospongiosus and the superficial portion of the external anal sphincter (EAS) were continuous anatomically with a common innervation in 92.3% of specimens. The superficial transverse perineal muscle inserted anterior and lateral to the midline, interdigitating with bulbospongiosus. The three EAS subdivisions were anatomically discontinuous. Additionally, in 89.2% of our sample the inferior rectal nerve emerged as a branch of S3 and S4 distinct from the pudendal nerve and innervated only the subcutaneous EAS. Branches of the perineal nerve innervated bulbospongiosus and the superficial EAS and nerve to levator ani innervated the deep EAS. In conclusion, we empirically demonstrate important and clinically relevant differences with perineal anatomy commonly described in standard texts. First, independent innervation to the three portions of EAS suggests the potential for functional independence. Second, neuromuscular continuity between bulbospongiosus and superficial EAS suggests the possibility of shared or overlapping function of the urogenital and anal triangles. Clin. Anat. 29:1053–1058, 2016. © 2016 Wiley Periodicals, Inc. 相似文献
9.
Unexpected Immunoresponse to Gal and APA Antigens in Diabetic Type 1 Patients Receiving Neonatal Pig Islets After 6 Years 总被引:1,自引:0,他引:1
Valdés-González RA Dorantes LM Garibay GN Bracho-Blanchet E Dávila-Pérez R Terán L Ormsby CE Ayala-Sumuano JT Copeman L White DJ 《Journal of clinical immunology》2007,27(3):266-274
Cotransplantation of porcine islets and Sertoli cells into preimplanted subcutaneous devices improve metabolic control in
type 1 diabetic patients, and survive grafted for more than 4 years. We report here, further assessment of the endocrine and
porcine nature of the surviving cells and the immune responses elicited toward Gal α(1,3)-Gal β(1,4)-GlcNAc (Gal) antigen
in patients who received a second and third transplants. No immunosuppressive drugs were administered. We were able to immunostain
insulin- and glucagon-positive cells in all biopsies of patients and Sertoli cell markers in 60.9% of biopsies. Additionally,
all biopsies tested, amplified the porcine COII gene. Patients demonstrated an increase in antipig antibodies in response
to the first transplant with a decreasing response toward the second and third transplants. In all transplants, the IgG levels
promptly returned to basal values after 3–4 months. The long-term survival of porcine cells and the reduced humoral immune
response to multiple transplants indicate a form of tolerance. We have not been able to find CD25-positive cells, indicating
that it is probably an immune accommodation of the graft. 相似文献
10.
BERNARDO LÉO WAJCHENBERG FERNANDO PRESTES CESAR CARLOS EDUARDO LEME RENATO DIDIO JÚLIO KIEFFER 《Clinical endocrinology》1978,8(3):233-236
The disappearance curves of plasma insulin after intravenous injection of unlabelled pork insulin was studied in nine young female hyperthyroid subjects with Graves' disease and eleven young female normal subjects, who served as controls. Comparison of the curves by analysis of variance did not reveal statistical differences between them (F obtained = 2.8, F F 0.05 = 4.41), implying that there was no significant differences in the transference of injected insulin from plasma to the extra-vascular space between hyper- and euthyroid subjects. The results may suggest that the metabolism of insulin is not appreciably affected in hyperthyroidism. 相似文献