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ALBERTO Q FARIAS LUCIANA L GONÇALVES EDUARDO LR CANÇADO ANTONIO C SEGURO SILVIA B CAMPOS CLARICE P ABRANTES-LEMOS FLAIR J CARRILHO 《Journal of gastroenterology and hepatology》2006,20(1):147-152
Background and Aims: Primary biliary cirrhosis (PBC) might be complicated by osteoporosis, whose etiology remains unknown but seems to be multifactorial. Prevalence rates of 30% to 60% for distal renal tubular acidosis (DRTA) have been reported in PBC patients, generally as incomplete DRTA. Although it is undisputed that a reduced bone mineral density (BMD) is the expected outcome among patients who have been suffering from longstanding chronic metabolic acidosis, it is unclear if incomplete DRTA is also associated with metabolic bone disease in PBC patients. The present study was undertaken to compare the BMD of PBC patients with and without DRTA.
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
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MIGUEL Kreisler ANTONIO Arnaiz EENIGNO Perez EDUARDO FERNANDEZ Cruz ALFREDO Bootello 《Tissue antigens》1974,4(2):197-201
HL—A phenotype frequencies were studied in 30 patients with leprosy and in 149 healthy controls. Leprosy patients had a significantly higher frequency of HL—A14. In addition, a majority of the HL—A14 patients gave a negative response to leproma antigen using the Mitsuda test. 相似文献
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Atypical Response to Diagnostic Maneuvers in a Narrow QRS Tachycardia: What is the Mechanism?
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Wireless Ultrasound Guidance for Femoral Venous Cannulation in Electrophysiology: Impact on Safety,Efficacy, and Procedural Delay
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DANIEL RODRÍGUEZ MUÑOZ M.D. EDUARDO FRANCO DÍEZ M.D. JAVIER MORENO M.D. Ph.D. GIUSEPPE LUMIA M.D. ALEJANDRA CARBONELL SAN ROMÁN M.D. TERESA SEGURA DE LA CAL M.D. ROBERTO MATÍA FRANCÉS M.D. Ph.D. ANTONIO HERNÁNDEZ MADRID M.D. Ph.D. JOSÉ LUIS ZAMORANO GÓMEZ M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2015,38(9):1058-1065
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EDUARDO ARANA‐RUEDA M.D. Ph.D. ALONSO PEDROTE M.D. Ph.D. LORENA GARCÍA‐RIESCO M.D. ALVARO ARCE‐LEÓN M.D. FEDERICO GÓMEZ‐PULIDO M.D. JUAN‐MANUEL DURÁN‐GUERRERO M.D. AGUSTÍN FERNÁNDEZ‐CISNAL M.D. MANUEL FRUTOS‐LÓPEZ M.D. JUAN‐ANTONIO SÁNCHEZ‐BROTONS M.D. 《Pacing and clinical electrophysiology : PACE》2015,38(2):216-224