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排序方式: 共有364条查询结果,搜索用时 93 毫秒
1.
Oscillatory motion of the normal cervical spinal cord 总被引:2,自引:0,他引:2
2.
3.
L. B. Dudnik A. N. Tsupko M. A. Shupik G. G. Akhaladze E. I. Galperin L. V. Platonova E. A. Pantaz A. V. Alessenko 《Bulletin of experimental biology and medicine》2008,145(1):33-36
Restoration of bile flow after 9-day cholestasis in rat liver normalized the content of lipid peroxidation products. The removal
of the cholestatic factor after 12-day cholestasis was not followed by recovery of these parameters. We showed that measurement
of serum concentration of lipid peroxidation products in patients with cholelithiasis during the preoperative period holds
promise for selection of the optimum time for surgical treatment and prediction of the risk of postoperative complications.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 1, pp. 39–42, January, 2008 相似文献
4.
Savchenkova AP Dudnik LB Pogoretskaya IL Solov'eva NP Pokrovskaya MA Aseichev AV Drinitsyna SV Azizova OA Lopukhin YM 《Bulletin of experimental biology and medicine》2003,135(1):29-33
In patients with coronary heart disease oxidizability of lipids during Cu2+-induced oxidation of blood plasma inversely correlated with fibrinogen content. A positive correlation was found between the amount of lipid peroxidation products in the plasma from these patients and fibrinogen content. The increase in fibrinogen content was associated with high levels of total lipids and triglycerides and low concentration of high-density lipoprotein cholesterol. In vitro experiments demonstrated that fibrinogen reduces oxidizability of blood plasma. Our results suggest that the decrease in lipid oxidizability at high concentration of fibrinogen in patients with coronary heart disease is related to predominant oxidation of fibrinogen and its competition with plasma lipids during Cu2+-induced oxidation. 相似文献
5.
Primary biliary cirrhosis and coronary atherosclerosis: Protective antioxidant effect of bilirubin 总被引:1,自引:0,他引:1
L. B. Dudnik O. A. Azyzova N. P. Solovyova A. P. Savchenkova M. A. Pokrovskaya 《Bulletin of experimental biology and medicine》2008,145(1):18-22
Increased concentration of lipid peroxidation products in patients with primary biliary cirrhosis is related to elevation
of serum lipid content, but not to activation of lipid peroxidation. Hyperbilirubinemia in patients with primary biliary cirrhosis
is accompanied by a decrease in the concentration of lipid peroxidation products and increase in antioxidant activity of blood
serum. Antioxidants play a major role in the prevention of atherosclerosis. We hypothesized that the absence of increased
risk of atherosclerosis in patients with primary biliary cirrhosis is due to inhibition of lipid peroxidation in blood serum
by antioxidant compound bilirubin.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 1, pp. 23–28, January, 2008 相似文献
6.
Mutational analysis of the SOX9 gene in campomelic dysplasia and autosomal sex reversal: lack of genotype/phenotype correlations 总被引:9,自引:1,他引:9
Meyer J; Sudbeck P; Held M; Wagner T; Schmitz ML; Bricarelli FD; Eggermont E; Friedrich U; Haas OA; Kobelt A; Leroy JG; Van Maldergem L; Michel E; Mitulla B; Pfeiffer RA; Schinzel A; Schmidt H; Scherer G 《Human molecular genetics》1997,6(1):91-98
It has previously been shown that, in the heterozygous state, mutations in
the SOX9 gene cause campomelic dysplasia (CD) and the often associated
autosomal XY sex reversal. In 12 CD patients, 10 novel mutations and one
recurrent mutation were characterized in one SOX9 allele each, and in one
case, no mutation was found. Four missense mutations are all located within
the high mobility group (HMG) domain. They either reduce or abolish the
DNA-binding ability of the mutant SOX9 proteins. Among the five nonsense
and three frameshift mutations identified, two leave the C-terminal
transactivation (TA) domain encompassing residues 402-509 of SOX9 partly or
almost completely intact. When tested in cell transfection experiments, the
recurrent nonsense mutation Y440X, found in two patients who survived for
four and more than 9 years, respectively, exhibits some residual
transactivation ability. In contrast, a frameshift mutation extending the
protein by 70 residues at codon 507, found in a patient who died shortly
after birth, showed no transactivation. This is apparently due to
instability of the mutant SOX9 protein as demonstrated by Western blotting.
Amino acid substitutions and nonsense mutations are found in patients with
and without XY sex reversal, indicating that sex reversal in CD is subject
to variable penetrance. Finally, none of 18 female patients with XY gonadal
dysgenesis (Swyer syndrome) showed an altered SOX9 banding pattern in SSCP
assays, providing evidence that SOX9 mutations do not usually result in XY
sex reversal without skeletal malformations.
相似文献
7.
Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse 总被引:1,自引:3,他引:1
8.
9.
10.
PO Ajiboye OA Abiodun MF Tunde-Ayinmode OIN Buhari EO Sanya KW Wahab 《African health sciences》2013,13(3):624-631