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1.
Alexander Real Chierika Ukogu Divya Krishnamoorthy Nicole Zubizarreta Samuel K. Cho Andrew C. Hecht James C. Iatridis 《The spine journal》2019,19(2):225-231
Background Context
Low back pain (LBP) is a common complaint in clinical practice of multifactorial origin. Although obesity has been thought to contribute to LBP primarily by altering the distribution of mechanical loads on the spine, the additional contribution of obesity-related conditions such as diabetes mellitus (DM) to LBP has not been thoroughly examined.Purpose
To determine if there is a relationship between DM and LBP that is independent of body mass index (BMI) in a large cohort of adult survey participants.Study Design
Retrospective analysis of prospectively collected National Health and Nutrition Examination Survey (NHANES) data to characterize associations between LBP, DM, and BMI in adults subdivided into 6 subpopulations: normal weight (BMI 18.5–25), overweight (BMI 25–30), and obese (BMI >30) diabetics and nondiabetics. Diabetes was defined with glycohemoglobin A1c (HbA1c) ≥6.5%.Patient Sample
11,756 participants from NHANES cohort.Outcome Measures
Percentage of LBP reported.Methods
LBP reported in the 1999-2004 miscellaneous pain NHANES questionnaire was the dependent variable examined. Covariates included HbA1c, BMI, age, and family income ratio to poverty as continuous variables as well as race, gender, and smoking as binary variables. Individuals were further subdivided by weight class and diabetes status. Regression and graphical analyses were performed on the study population as a whole and also on subpopulations.Results
Increasing HbA1c did not increase the odds of reporting LBP in the full cohort. However, multivariate logistic regression of the 6 subpopulations revealed that the odds of LBP significantly increased with increasing HbA1c levels in normal weight diabetics. No other subpopulations reported significant relationships between LBP and HbA1c. LBP was also significantly associated with BMI for normal weight diabetics and also for obese subjects regardless of their DM status.Conclusions
LBP is significantly related to DM status, but this relationship is complex and may interact with BMI. These results support the concept that LBP may be improved in normal weight diabetic subjects with improved glycemic control and weight loss, and that all obese LBP subjects may benefit from improved weight loss alone. 相似文献2.
BackgroundExcessive consumption of ethanol is known to activate the mTORC1 pathway and to enhance the Collapsin Response Mediator Protein-2 (CRMP-2) levels in the limbic region of brain. The latter helps in forming microtubule assembly that is linked to drug taking or addiction-like behavior in rodents. Therefore, in this study, we investigated the effect of lacosamide, an antiepileptic drug and a known CRMP-2 inhibitor, which binds to CRMP-2 and inhibits the formation of microtubule assembly, on ethanol-induced conditioned place preference (CPP) in mice.MethodsThe behavior of mice following ethanol addiction and withdrawal was assessed by performing different behavioral paradigms. Mice underwent ethanol-induced CPP training with alternate dose of ethanol (2 g/kg, po) and saline (10 ml/kg, po). The effect of lacosamide on the expression of ethanol-induced CPP and on ethanol withdrawal associated anxiety and depression-like behavior was evaluated. The effect of drug on locomotor activity was also assessed and hippocampal CRMP-2 levels were measured.ResultsEthanol-induced CPP was associated with enhanced CRMP-2 levels in the hippocampus. Lacosamide significantly reduced the expression of ethanol-induced CPP and alleviated the levels of hippocampal CRMP-2 but aggravated withdrawal-associated anxiety and depression in mice.ConclusionThe present study demonstrated the beneficial effect of lacosamide in attenuation of expression of ethanol induced conditioned place preference via reduction of hippocampal CRMP-2 level. These findings suggest that lacosamide may be investigated further for ethanol addiction but not for managing withdrawal. 相似文献
3.
In India, all national nutrition programs and activities are carried out by staff at the primary health centers under the leadership of medical officers. A study of 114 of these officers from 80 primary health centers in rural districts of Andhra Pradesh State was undertaken to assess their knowledge and performance, particularly with regard to nutrition and related matters. Scores were expressed in percentages, with under 50% considered poor, 50-75% satisfactory, and over 75% good. The highest score 67.7% was obtained on knowledge of nutrition and related areas, and the lowest, 19.7% was for the participant's awareness of their own job responsibilities. Although overall theoretical knowledge on nutrition and related matters was satisfactory, significant gaps existed. A majority were ignorant as to how many people were covered by their centers and the numbers of staff in different categories, suggesting little attention was being given to planning and implementation of various services. Only 23% were aware of their own responsibilities regarding nutrition, and only 16% mentioned teaching nutrition during their training programs. The conclusion is that the medical education system must be better coordinated with the health care delivery infrastructure. Medical undergraduates need more exposure to Practical aspects of health care in rural communities, managerial aspects of work in primary health centers, and programs with a stronger nutrition component. In addition, refresher courses must be offered, and the problem of overburdening the medical officers must be dealt with. 相似文献
4.
Divya Prabhat S. K. Bhargava K. N. Dandekar S. B. Ogale 《Indian journal of otolaryngology and head and neck surgery》1993,45(1):31-32
Malignancies of the middle ear and mastoid are rare and secondaries in the ear are extremely rare. A rare case of metastic adenocarcinoma from the breast is presented herewith. 相似文献
5.
Chunguang Chen Divya Rawat Balaji Samikannu Markus Bender Klaus T. Preissner Thomas Linn 《American journal of transplantation》2021,21(6):2079-2089
Platelet activation and thrombus formation have been implicated to be detrimental for intraportal pancreatic islet transplants. The platelet-specific collagen receptor glycoprotein VI (GPVI) plays a key role in thrombosis through cellular activation and the subsequent release of secondary mediators. In aggregometry and in a microfluidic dynamic assay system modeling flow in the portal vein, pancreatic islets promoted platelet aggregation and triggered thrombus formation, respectively. While platelet GPVI deficiency did not affect the initiation of these events, it was found to destabilize platelet aggregates and thrombi in this process. Interestingly, while no major difference was detected in early thrombus formation after intraportal islet transplantation, genetic GPVI deficiency or acute anti-GPVI treatment led to an inferior graft survival and function in both syngeneic mouse islet transplantation and xenogeneic human islet transplantation models. These results demonstrate that platelet GPVI signaling is indispensable in stable thrombus formation induced by pancreatic islets. GPVI deficiency resulted in thrombus destabilization and inferior islet engraftment indicating that thrombus formation is necessary for a successful intraportal islet transplantation in which platelets are active modulators. 相似文献
6.
Ramnath T Krishnamachari KA 《Indian journal of maternal and child health : official publication of Indian Maternal and Child Health Association,》1993,4(2):42-47
In October-November 1987 in India, the Desert Medicine Research Centre in Jodhpur conducted a rapid anthropometric survey of 555 preschool children in 4 districts of Rajasthan which had been severely affected by drought (Jodhpur, Jalore, Nagpur, and Barmer districts) to determine the association between anthropometric measurements and various nutritional deficiency signs and infections. Based on weight for age, 82.3% of the children were undernourished. 13.3% of all children were severely malnourished (grade III undernutrition). Anemia, protein energy malnutrition (PEM), and upper respiratory infections occurred significantly more often as one digressed from the normal nutrition grade. These 3 conditions were also closely linked to weight status. Based on height for age, 62.4% of the children were chronically undernourished. 11.9% of all children were severely so. PEM was the only deficiency sign or infection associated with height status (6.2% of children with normal nutrition had PEM vs. 15.% for grade I undernutrition and 34.8% for grade II undernutrition; p .001). Vitamin A deficiency, anemia, and PEM occurred more frequently as one went from normal nutrition to grade II undernutrition based on fat fold at triceps (FFT) measurements. PEM and upper respiratory infections were significantly associated with weight for height status. Weight correctly identified 84% of all nutritional deficiency signs and infections. The corresponding figures for height, FFT, and weight for height were 64.2%, 75.4%, and 31%. Thus, weight was the most sensitive screening measurement in identifying nutritional deficiency signs and infections. Based on weight alone, the odds ratio of undernourished children developing Vitamin b-complex deficiency, PEM, and upper respiratory infections was 1.58, 3.25, and 1.77, respectively. Weight for height was the most specific screening measurement (88.2% vs. 44.7% for height, 29.3% for FFT, and 26.1% for weight). 相似文献
7.
Sangeeta Varty Dinesh Vaidya Kamal Parasram Divya Prabhat Sudhir Joshi 《Indian journal of otolaryngology and head and neck surgery》2000,52(2):143-146
Tuberculosis of the middle ear it a rare disease. Due to change in the typical clinical pattern and decrease in incidence,
there is a delayed or missed diagnosis and can lead to increased morbidity. We pretent 5 cases of Tuberculous Otitis Media
treated over a period of 2 years, highlighting the fact that it must be considered as a differential diagnosis of persistent
suppurative otitis media. 相似文献
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10.
Divya Sharma Manila Lather Cherry L. Dykes Amita S. Dang Tridibes Adak Om P. Singh 《Parasitology research》2016,115(1):323-328