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1.
E.M. Brouwer-Brolsma D. Sluik C.M. Singh-Povel E.J.M. Feskens 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2018,28(5):451-460
Background and aims
Previous studies have suggested weight–regulatory properties for several dairy nutrients, but population-based studies on dairy and body weight are inconclusive. We explored cross–sectional associations between dairy consumption and indicators of overweight.Methods and results
We included 114,682 Dutch adults, aged ≥18 years. Dairy consumption was quantified by a food frequency questionnaire. Abdominal overweight was defined as waist circumference (WC) ≥88 cm (women) or ≥102 cm (men) (n = 37,391), overweight as BMI ≥25–30 kg/m2 (n = 44,772) and obesity as BMI ≥30 kg/m2 (n = 15,339). Associations were quantified by logistic (abdominal overweight, no/yes), multinomial logistic (BMI-defined overweight and obesity) and linear regression analyses (continuous measures of WC and BMI), and they were adjusted for relevant covariates. Total dairy showed a positive association with abdominal overweight (OR Q1 ref vs. Q5: 1.09; 95% CI: 1.04–1.14) and with BMI-defined overweight (OR Q5 1.13; 95% CI: 1.08–1.18) and obesity (OR Q5 1.09; 95% CI: 1.02–1.16). Skimmed, semi-skimmed and non-fermented dairy also showed positive associations with overweight categories. Full-fat dairy showed an inverse association with overweight and obesity (OR Q5 for obesity: 0.78; 95% CI: 0.73–0.83). Moreover, inverse associations were observed for yoghurt and custard and positive associations for milk, buttermilk, flavoured yoghurt drinks, cheese and cheese snacks. Fermented dairy, curd cheese and Dutch cheese did not show a consistent association with overweight categories.Conclusions
Total, skimmed, semi-skimmed and non-fermented dairy; milk; buttermilk; flavoured yoghurt drinks; total cheese and cheese snacks showed a positive association with overweight categories, whereas full-fat dairy, custard and yoghurt showed an inverse association with overweight categories. 相似文献2.
Diewertje Sluik Heiner Boeing Kuanrong Li Rudolf Kaaks Nina Føns Johnsen Anne Tjønneland Larraitz Arriola Aurelio Barricarte Giovanna Masala Sara Grioni Rosario Tumino Fulvio Ricceri Amalia Mattiello Annemieke M. W. Spijkerman Daphne L. van der A Ivonne Sluijs Paul W. Franks Peter M. Nilsson Marju Orho-Melander Eva Fhärm Olov Rolandsson Elio Riboli Dora Romaguera Elisabete Weiderpass Emilio Sánchez-Cantalejo Ute Nöthlings 《Diabetologia》2014,57(1):63-72
Aims/hypothesis
Thus far, it is unclear whether lifestyle recommendations for people with diabetes should be different from those for the general public. We investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes.Methods
Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was formed of 6,384 persons with diabetes and 258,911 EPIC participants without known diabetes. Joint Cox proportional hazard regression models of people with and without diabetes were built for the following lifestyle factors in relation to overall mortality risk: BMI, waist/height ratio, 26 food groups, alcohol consumption, leisure-time physical activity, smoking. Likelihood ratio tests for heterogeneity assessed statistical differences in regression coefficients.Results
Multivariable adjusted mortality risk among individuals with diabetes compared with those without was increased, with an HR of 1.62 (95% CI 1.51, 1.75). Intake of fruit, legumes, nuts, seeds, pasta, poultry and vegetable oil was related to a lower mortality risk, and intake of butter and margarine was related to an increased mortality risk. These associations were significantly different in magnitude from those in diabetes-free individuals, but directions were similar. No differences between people with and without diabetes were detected for the other lifestyle factors.Conclusions/interpretation
Diabetes status did not substantially influence the associations between lifestyle and mortality risk. People with diabetes may benefit more from a healthy diet, but the directions of association were similar. Thus, our study suggests that lifestyle advice with respect to mortality for patients with diabetes should not differ from recommendations for the general population. 相似文献3.
Sluik D Oude Griep LM Geleijnse JM 《The American journal of clinical nutrition》2007,86(5):1548; author reply 1548-1548; author reply 1549
4.
van Dieren S Nöthlings U van der Schouw YT Spijkerman AM Rutten GE van der A DL Sluik D Weikert C Joost HG Boeing H Beulens JW 《Diabetologia》2011,54(1):73-77
Aims/hypothesis
The aim of this study was to examine the effect of postprandial time on the associations and predictive value of non-fasting lipid levels and cardiovascular disease risk in participants with diabetes.Methods
This study was conducted among 1,337 participants with diabetes from the Dutch and German (Potsdam) contributions to the European Prospective Investigation into Cancer and Nutrition. At baseline, total cholesterol, LDL- and HDL-cholesterol and triacylglycerol concentrations were measured and the ratio of total cholesterol/HDL-cholesterol was calculated. Participants were followed for incidence of cardiovascular disease.Results
Lipid concentrations changed minimally with increasing postprandial time, except for triacylglycerol which was elevated just after a meal and declined over time (1.86 at 0.1?h to 1.33 at >6?h, p for trend <0.001). During a mean follow-up of 8?years, 116 cardiovascular events were documented. After adjustment for potential confounders, triacylglycerol (HR for third tertile compared with first tertile (HRt3to1), 1.73 [95% CI 1.04, 2.87]), HDL-cholesterol (HRt3to1, 0.41 [95% CI 0.23, 0.72]) and total cholesterol/HDL-cholesterol ratio (HRt3to1, 1.65 [95% CI 0.95, 2.85]) were associated with cardiovascular disease, independent of postprandial time. Cardiovascular disease risk prediction using the UK Prospective Diabetes Study risk engine was not affected by postprandial time.Conclusions/interpretation
Postprandial time did not affect associations between lipid concentrations and cardiovascular disease risk in patients with diabetes, nor did it influence prediction of cardiovascular disease. Therefore, it may not be necessary to use fasting blood samples to determine lipid concentrations for cardiovascular disease risk prediction in patients with diabetes. 相似文献5.
Hendriksen H Meulendijks D Douma TN Bink DI Breuer ME Westphal KG Olivier B Oosting RS 《Neuropharmacology》2012,62(1):270-277
Depression, especially in the elderly, is associated with poor cognitive functioning. Exercise has received much attention in the treatment for depression and also dementia. Here we studied the effect of an enriched environment combined with voluntary exercise (EE/VE) on the olfactory bulbectomized (OBX) rat. The OBX rat is hyperactive in an open field, which is normalized by chronic antidepressant treatment, and suffers from learning and memory impairments. Neurotrophic factors are thought to be involved in the antidepressant action of EE/VE. Hyperactivity and cognitive functioning (both hippocampal dependent and independent tasks) were investigated before and after EE/VE. We quantified hippocampal mRNA levels of the neurotrophic factors BDNF, VGF and VEGF. VEGF receptor (FLK-1) inhibition was achieved by i.c.v administration of the antagonist SU5416 during the period of EE/VE. OBX almost completely blocked fear memory acquired either 48 h or 28 days before surgery. EE/EV normalized OBX-induced hyperactivity in open field, while having no effect on the decrease in hippocampal dependent learning and memory. VEGF mRNA levels in hippocampus were significantly increased both in OBX and control rats following EE/VE. OBX reduced BDNF mRNA levels, but EE did not reverse this. Inhibition of the FLK-1 receptor did not suppress EE/VE induced normalization of the hyperactivity of the OBX rat. The lack of effect of EE/VE on cognitive parameters, while normalizing hyperactivity, suggests different neuronal mechanisms underlying OBX-induced behavioral changes. Since EE/VE still normalizes the OBX-induced hyperactivity while the FLK-1 receptor was blocked, we assume that VEGF is not obligatory for the antidepressant effect of EE/VE. This article is part of a Special Issue entitled 'Anxiety and Depression'. 相似文献
6.
Grote VA Rohrmann S Nieters A Dossus L Tjønneland A Halkjær J Overvad K Fagherazzi G Boutron-Ruault MC Morois S Teucher B Becker S Sluik D Boeing H Trichopoulou A Lagiou P Trichopoulos D Palli D Pala V Tumino R Vineis P Panico S Rodríguez L Duell EJ Molina-Montes E Dorronsoro M Huerta JM Ardanaz E Jeurnink SM Beulens JW Peeters PH Sund M Ye W Lindkvist B Johansen D Khaw KT Wareham N Allen N Crowe F Jenab M Romieu I Michaud DS Riboli E Romaguera D Bueno-de-Mesquita HB Kaaks R 《Diabetologia》2011,54(12):3037-3046
Aims/hypothesis
There has been long-standing debate about whether diabetes is a causal risk factor for pancreatic cancer or a consequence of tumour development. Prospective epidemiological studies have shown variable relationships between pancreatic cancer risk and blood markers of glucose and insulin metabolism, overall and as a function of lag times between marker measurements (blood donation) and date of tumour diagnosis.Methods
Pre-diagnostic levels of HbA1c and C-peptide were measured for 466 participants with pancreatic cancer and 466 individually matched controls within the European Prospective Investigation into Cancer and Nutrition. Conditional logistic regression models were used to estimate ORs for pancreatic cancer.Results
Pancreatic cancer risk gradually increased with increasing pre-diagnostic HbA1c levels up to an OR of 2.42 (95% CI 1.33, 4.39 highest [??6.5%, 48?mmol/mol] vs lowest [??5.4%, 36?mmol/mol] category), even for individuals with HbA1c levels within the non-diabetic range. C-peptide levels showed no significant relationship with pancreatic cancer risk, irrespective of fasting status. Analyses showed no clear trends towards increasing hyperglycaemia (as marked by HbA1c levels) or reduced pancreatic beta cell responsiveness (as marked by C-peptide levels) with decreasing time intervals from blood donation to cancer diagnosis.Conclusions/interpretation
Our data on HbA1c show that individuals who develop exocrine pancreatic cancer tend to have moderate increases in HbA1c levels, relatively independently of obesity and insulin resistance??the classic and major risk factors for type 2 diabetes. While there is no strong difference by lag time, more data are needed on this in order to reach a firm conclusion. 相似文献7.
8.
Diewertje Houtman Boy Vijlbrief Marike Polak Jacqueline Pot Petra Verhoef Martina Cornel Sam Riedijk 《European journal of human genetics : EJHG》2023,31(4):409
Public engagement for Human Germline Genome Editing (HGGE) has often been called for, for example by the WHO. However, the impact of public engagement remains largely unknown. This study reports on public engagement outcomes in the context of a public dialogue project about HGGE in the Netherlands; the DNA-dialogue. The aim was to inquire opinions and opinion change regarding HGGE. A questionnaire was distributed on a national level (n = 2381) and a dialogue level (n = 414). The results indicate that the majority of the Dutch population agrees with the use of HGGE to prevent severe genetic diseases (68.6%), unlike the use to protect against infectious diseases (39.7%), or for enhancement (8.5%). No indications of change in these acceptance rates as a result of dialogue participation were found. The results did provide a tentative indication that participation in dialogue may lead to less negative opinions about HGGE (χ2(1) = 5.14, p = 0.023, OR = 0.56, 95% CI [0.34, 0.93]). While it was not a goal of the project to make people more accepting towards HGGE, this might be the effect of exposure to opinions that are less often heard in the global debate. We conclude that dialogue may lead to different outcomes for different people, depending on their characteristics and their entrance attitude, but does not appear to systematically direct people towards a certain opinion. The self-reported, impacts of dialogue participation included no impact, strengthening of opinion, enabling of forming a first opinion, more insight into the potential implications of HGGE, and a better understanding of other people’s perspectives.Subject terms: Gene therapy, Health policy, Medical ethics, Ethics 相似文献
9.
Sluik D Boeing H Bergmann MM Schütze M Teucher B Kaaks R Tjønneland A Overvad K Arriola L Ardanaz E Bendinelli B Agnoli C Tumino R Ricceri F Mattiello A Spijkerman AM Beulens JW Grobbee DE Nilsson PM Melander O Franks PW Rolandsson O Riboli E Gallo V Romaguera D Nöthlings U 《The British journal of nutrition》2012,108(7):1307-1315
Studies have suggested that moderate alcohol consumption is associated with a reduced risk of CVD and premature mortality in individuals with diabetes mellitus. However, history of alcohol consumption has hardly been taken into account. We investigated the association between current alcohol consumption and mortality in men and women with diabetes mellitus accounting for past alcohol consumption. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort was defined of 4797 participants with a confirmed diagnosis of diabetes mellitus. Men and women were assigned to categories of baseline and past alcohol consumption. Hazard ratios (HR) and 95?% CI for total mortality were estimated with multivariable Cox regression models, using light alcohol consumption (>0-6?g/d) as the reference category. Compared with light alcohol consumption, no relationship was observed between consumption of 6?g/d or more and total mortality. HR for >6-12?g/d was 0·89 (95?% CI 0·61, 1·30) in men and 0·86 (95?% CI 0·46, 1·60) in women. Adjustment for past alcohol consumption did not change the estimates substantially. In individuals who at baseline reported abstaining from alcohol, mortality rates were increased relative to light consumers: HR was 1·52 (95?% CI 0·99, 2·35) in men and 1·81 (95?% CI 1·04, 3·17) in women. The present study in diabetic individuals showed no association between current alcohol consumption >6?g/d and mortality risk compared with light consumption. The increased mortality risk among non-consumers appeared to be affected by their past alcohol consumption rather than their current abstinence. 相似文献
10.
Sylvia Hansen Maija Huttunen-Lenz Diewertje Sluik Jennie Brand-Miller Mathijs Drummen Mikael Fogelholm Teodora Handjieva-Darlenska Ian Macdonald Alfredo J. Martinez Thomas Meinert Larsen Sally Poppitt Anne Raben Wolfgang Schlicht 《International journal of behavioral medicine》2018,25(6):682-692