全文获取类型
收费全文 | 25306篇 |
免费 | 1783篇 |
国内免费 | 70篇 |
专业分类
耳鼻咽喉 | 255篇 |
儿科学 | 653篇 |
妇产科学 | 715篇 |
基础医学 | 3759篇 |
口腔科学 | 1114篇 |
临床医学 | 2852篇 |
内科学 | 4595篇 |
皮肤病学 | 685篇 |
神经病学 | 2564篇 |
特种医学 | 532篇 |
外科学 | 2413篇 |
综合类 | 137篇 |
一般理论 | 47篇 |
预防医学 | 2690篇 |
眼科学 | 422篇 |
药学 | 1838篇 |
中国医学 | 75篇 |
肿瘤学 | 1813篇 |
出版年
2024年 | 20篇 |
2023年 | 272篇 |
2022年 | 464篇 |
2021年 | 1008篇 |
2020年 | 564篇 |
2019年 | 884篇 |
2018年 | 976篇 |
2017年 | 716篇 |
2016年 | 828篇 |
2015年 | 889篇 |
2014年 | 1188篇 |
2013年 | 1430篇 |
2012年 | 2168篇 |
2011年 | 2288篇 |
2010年 | 1204篇 |
2009年 | 965篇 |
2008年 | 1593篇 |
2007年 | 1668篇 |
2006年 | 1551篇 |
2005年 | 1383篇 |
2004年 | 1138篇 |
2003年 | 992篇 |
2002年 | 940篇 |
2001年 | 164篇 |
2000年 | 136篇 |
1999年 | 151篇 |
1998年 | 138篇 |
1997年 | 104篇 |
1996年 | 90篇 |
1995年 | 76篇 |
1994年 | 88篇 |
1993年 | 72篇 |
1992年 | 77篇 |
1991年 | 82篇 |
1990年 | 67篇 |
1989年 | 62篇 |
1988年 | 62篇 |
1987年 | 32篇 |
1986年 | 43篇 |
1985年 | 56篇 |
1984年 | 46篇 |
1983年 | 40篇 |
1982年 | 37篇 |
1981年 | 41篇 |
1980年 | 36篇 |
1979年 | 23篇 |
1978年 | 29篇 |
1977年 | 29篇 |
1976年 | 18篇 |
1974年 | 25篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Andres Eduardo Campuzano-García Bertha Torres-Alvarez Diana Hernández-Blanco 《Journal of cosmetic and laser therapy》2015,17(4):213-215
Hailey–Hailey disease (HHD), also known as benign familial pemphigus, is an autosomal dominant skin condition that affects the adhesion of epidermal keratinocytes. Although the initial manifestation of flaccid vesicles on erythematous or normal skin in flexure sites frequently goes unnoticed, large, macerated, exudative plaques of superficial erosions with crusting are observed at the time of diagnosis. There is no specific treatment for HHD, and most cases are symptomatically supported. However, infrared laser ablation has been somewhat helpful. We present a case successfully treated with fractional CO2 laser showing a long-term favourable outcome and no adverse effects. Thus, this modality could be an alternative to full ablation for this condition. 相似文献
5.
6.
David M. Presby Michael C. Rudolph Vanessa D. Sherk Matthew R. Jackman Rebecca M. Foright Kenneth L. Jones Julie A. Houck Ginger C. Johnson Janine A. Higgins P. Darrell Neufer Robert H. Eckel Paul S. MacLean 《Diabetes》2021,70(4):867
Moderate weight loss improves numerous risk factors for cardiometabolic disease; however, long-term weight loss maintenance (WLM) is often thwarted by metabolic adaptations that suppress energy expenditure and facilitate weight regain. Skeletal muscle has a prominent role in energy homeostasis; therefore, we investigated the effect of WLM and weight regain on skeletal muscle in rodents. In skeletal muscle of obesity-prone rats, WLM reduced fat oxidative capacity and downregulated genes involved in fat metabolism. Interestingly, even after weight was regained, genes involved in fat metabolism were also reduced. We then subjected mice with skeletal muscle lipoprotein lipase overexpression (mCK-hLPL), which augments fat metabolism, to WLM and weight regain and found that mCK-hLPL attenuates weight regain by potentiating energy expenditure. Irrespective of genotype, weight regain suppressed dietary fat oxidation and downregulated genes involved in fat metabolism in skeletal muscle. However, mCK-hLPL mice oxidized more fat throughout weight regain and had greater expression of genes involved in fat metabolism and lower expression of genes involved in carbohydrate metabolism during WLM and regain. In summary, these results suggest that skeletal muscle fat oxidation is reduced during WLM and regain, and therapies that improve skeletal muscle fat metabolism may attenuate rapid weight regain. 相似文献
7.
8.
9.
10.
Ana M. Gómez Angelica Imitola Diana Henao Maira García-Jaramillo Marga Giménez Clara Viñals Bruno Grassi Mariana Torres Isabella Zuluaga Oscar Mauricio Muñoz Martin Rondón Fabián León-Vargas Ignacio Conget 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2021,15(1):267-272
Background and aimsDespite using sensor-augmented pump therapy (SAPT) with predictive low-glucose management (PLGM), hypoglycemia is still an issue in patients with type 1 Diabetes (T1D). Our aim was to determine factors associated with clinically significant hypoglycemia (<54 mg/dl) in persons with T1D treated with PLGM-SAPT.Methodology: This is a multicentric prospective real-life study performed in Colombia, Chile and Spain. Patients with T1D treated with PLGM-SAPT, using sensor ≥70% of time, were included. Data regarding pump and sensor use patterns and carbohydrate intake from 28 consecutive days were collected. A bivariate and multivariate Poisson regression analysis was carried out, to evaluate the association between the number of events of <54 mg/dl with the clinical variables and patterns of sensor and pump use.Results188 subjects were included (41 ± 13.8 years-old, 23 ± 12 years disease duration, A1c 7.2% ± 0.9). The median of events <54 mg/dl was four events/patient/month (IQR 1–10), 77% of these events occurred during day time. Multivariate analysis showed that the number of events of hypoglycemia were higher in patients with previous severe hypoglycemia (IRR1.38; 95% CI 1.19–1.61; p < 0.001), high glycemic variability defined as Coefficient of Variation (CV%) > 36% (IRR 2.09; 95%CI 1.79–2.45; p < 0.001) and hypoglycemia unawareness. A protector effect was identified for adequate sensor calibration (IRR 0.77; 95%CI 0.66–0.90; p:0.001), and the use of bolus wizard >60% (IRR 0.74; 95%CI 0.58–0.95; p:0.017).ConclusionIn spite of using advanced SAPT, clinically significant hypoglycemia is still a non-negligible risk. Only the identification and intervention of modifiable factors could help to prevent and reduce hypoglycemia in clinical practice. 相似文献