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1.
Piero Volpi Luca Marinoni Corrado Bait Marco Galli Matteo Denti 《Knee surgery, sports traumatology, arthroscopy》2007,15(8):1028-1034
Lateral unicompartmental knee arthroplasty (UKA) is a valid alternative treatment in the event of arthritis confined to the
lateral compartment. This paper examines its indications, technique and short to medium-term results. A total of 159 Miller–Galante
cemented UKA prostheses (Zimmer, Warsaw, Indiana) were implanted consecutively (131 medial and 28 lateral) by the same surgeon.
This study investigates 28 lateral UKAs in 27 patients. Twenty-five implants in 24 patients (including a subject operated
bilaterally) were followed up for 12–60 months. Three patients were discarded on account of to short a follow-up period. The
Hospital for Special Surgery (HSS) knee score was used to compare the pre- and post-operative results of the lateral UKA patients.
The HSS score improved from a pre-op mean of 59.92 (range 48–68) to 88.04 (range 71–95) at the last follow-up. There was a
positive increase in the pain, function and ROM components of the score. The lateral UKA prosthesis can be regarded as a sound
alternative to total knee replacement. Correct patient selection on the basis of optimum surgical indications, however, is
essential.
No benefits of funds were received in support of the study. 相似文献
2.
M. Cervellin L. de Girolamo C. Bait M. Denti P. Volpi 《Knee surgery, sports traumatology, arthroscopy》2012,20(1):114-120
Purpose
Bone-patellar tendon–bone technique (BPTB) for anterior cruciate ligament injuries is associated with a higher risk of donor-site morbidity. To evaluate whether platelet-rich plasma (PRP), due to its anti-inflammatory properties and capacity to stimulate tissue regeneration, was able to reduce the anterior knee pain, the kneeling pain, and donor-site morbidity, as evidenced by evaluation of VISA and VAS scoring scales and MRI analysis of the tendon and bone defect, we performed a clinical randomized controlled study where PRP gel was applied to donor site after ACL reconstruction with BPTB. 相似文献3.
4.
Denti L Pasolini G Cortellini P Sanfelici L Benedetti R Cecchetti A Ferretti S Bruschieri L Ablondi F Valenti G 《Atherosclerosis》2000,152(1):159-166
Androgen effects on lipoproteins, mainly high density lipoprotein (HDL), could be exerted by a direct interaction of testosterone (T) or dihydrotestosterone (DHT) with liver androgen receptors. To assess if T needs to be converted into DHT to affect lipid metabolism, 13 patients were studied, affected with benign prostatic hyperplasia (BPH) and treated with an inhibitor of 5 alpha-reductase (finasteride). They were compared with 15 untreated controls. At baseline and after 3 and 6 months of therapy, each patient was evaluated as for lipoprotein and hormone concentrations, as well as for nutritional status. Body composition was assessed by anthropometry and bio-impedance analysis (BIA). Treatment was associated with a significant increase of HDL-cholesterol (HDL-C), mainly HDL3 subclass, and lipoprotein(a) (Lp(a)), as well as a decline of DHT, whereas no significant changes were apparent for T, estradiol (E2), sex hormone binding hormone (SHBG) and body composition indexes. However, no significant associations between DHT and lipid relative changes were apparent at bivariate correlation analysis. This finding was confirmed by comparing patient subsets identified by cluster analysis, according to HDL subclass individual responses. Rather, a slight association with E2 for HDL2 (positive) and HDL3 (negative) was found. In conclusion, finasteride can modify HDL and Lp(a) concentrations. However, by the data, these effects cannot be definitively attributed to the changes in DHT synthesis induced by finasteride, since a direct and non-specific interference of the drug on liver metabolism cannot be excluded. 相似文献
5.
Giulio Falasconi MD Francesco Melillo MD Luigi Pannone MD Marianna Adamo MD Federico Ronco MD Azeem Latib MD Kusha Rahgozar MD Nazario Carrabba MD Renato Valenti MD Rodolfo Citro MD Stefano Stella MD Giacomo Ingallina MD Cristina Capogrosso MD Mara Scandroglio MD Francesco Ancona MD Cosmo Godino MD Paolo Denti MD Alessandro Castiglioni MD Michele De Bonis MD Antonio Colombo MD Laura Lupi MD Luca Branca MD Matteo Montorfano MD Eustachio Agricola MD 《Catheterization and cardiovascular interventions》2021,98(1):E163-E170
6.
Licia Denti Andrea Artoni Umberto Scoditti Caterina Caminiti Fabiola Giambanco Monica Casella Gian Paolo Ceda 《European Journal of Internal Medicine》2013,24(8):807-812
BackgroundStroke outcome has been reported as worse in women, especially in terms of disability. As for mortality, the data are conflicting, with some reports suggesting a female advantage. Our objective was to explore such issues in an Italian cohort of patients managed by a standardized clinical pathway (CPW) and, as such, homogeneous in terms of clinical management.MethodsData from a cohort of 1993 patients (987 women and 1006 men) with first-ever ischemic stroke, consecutively referred to an in-hospital Clinical Pathway Program from January 1, 2001 to December 31, 2009, were retrospectively analyzed. The relationship between female gender and one-month outcome was assessed with adjustment for age, stroke severity and premorbid disability.ResultsThe outcome was worse in women in terms of disability (age-adjusted odds ratio 2.03, 95% CI 1.69–2.46), while no difference was found for mortality. In multivariate models, female gender turned out to be associated with a lower case-fatality rate (adjusted hazard ratio 0.65, 95% CI 0.48–0.89, P = 0.007), whereas the odds ratio for disability decreased but remained significant (OR 1.30; 95% CI 1.01–1.69). We found a significant interaction between gender and age in the case-fatality rate, and a female survival advantage was apparent only below 50 years.ConclusionsOur study confirms the excess risk of disability after stroke in women, although it is mostly explained by the occurrence of the most severe clinical syndromes. As for mortality, female gender seems to play a protective role, at least in the short-term and in younger patients. 相似文献
7.
Giuliano Malaguti DDS Lucia Denti PhD Elena Bassoli PhD Irene Franchi DDS Sergio Bortolini Prof. Andrea Gatto Prof. 《Clinical implant dentistry and related research》2011,13(2):134-140
Background: The clinical application of prosthetic components obtained by different manufacturing processes lacks technological foundation: the dimensional tolerance of individual parts and their assembly accuracy are not known. The rotational misfit (RM) of the hexagonal connection is critical in single‐tooth implant restorations, but no standard control procedures are available for its evaluation. Purpose: The research aimed at proposing a new protocol for the dimensional assessment of implant‐abutment connections, based on noncontact measurement and statistical data processing. The procedure was applied to machined‐ and cast‐on abutments, as well of the matching implants. Materials and Methods: Three groups of five abutments each were studied: machined titanium abutments, pre‐machined calcinable abutments before casting procedures and the same specimens after casting. A group of five corresponding implants was considered as well. Twice the apothem was measured on each hexagon through an optical measuring microscope. The data were processed to obtain the international tolerance (IT) grade. The RM was then calculated using the apothems of the external and the internal hexagon. Results: All the components were classified between IT8 and IT9, and the maximum RM was around 3–4° for all the assemblies, inferior to the critical limits for the screw joint stability. Conclusion: An original measuring protocol was developed, independent of parts assembly and based on ITs. An objective dimensional characterization of prosthetic components and assemblies has been achieved, which is the basis for their reliability in clinical applications. 相似文献
8.
G.?Melegati D.?TorneseEmail author M.?Bandi P.?Volpi H.?Schonhuber M.?Denti 《Knee surgery, sports traumatology, arthroscopy》2003,11(5):322-326
To evaluate the effects of a rehabilitation brace locked in extension for the first week on the recovery of full extension after ACL reconstruction we compared two groups of subjects who underwent ACL bone-patellar tendon-bone reconstruction. The brace was unlocked twice a day for assisted physiotherapy. In Group A, 18 male subjects wore a post-operative brace locked from 0 degrees to 90 degrees. In Group B, 18 male subjects wore the same post-op brace locked in full extension for the first week. In both groups the brace was unlocked (0 degrees -120 degrees ) at the beginning of the second postoperative week, and then removed at the beginning of the third week. All the subjects followed the same rigorous, accelerated rehabilitation protocol. Each subject was evaluated pre and post-operatively (at second, fourth and eighth week) with bubble-level heel height difference (HHD) measurements and KT 1000 arthrometric assessment at the fourth postoperative month. Preoperative bubble-level HHD measurements of the two groups were statistically similar (Group A 0.6 cm, Group B 1 cm; not significant, n.s.). At the fourth week (Group A 2.2 cm, Group B 0.6 cm) and eighth week (Group A 1.6 cm, Group B 0.1 cm) follow-ups, bubble-level HHD measurements showed that the extension of the operated knees of Group B was significantly greater than in Group A. KT 1000 arthrometric scores showed no difference between the two groups (Group A 1.8 mm, Group B 1.5; n.s.). 相似文献
9.
Atul Dave Nagpal Lucia Torracca Andrea Fumero Paolo Denti Micaela Cioni Ottavio Alfieri 《European journal of cardio-thoracic surgery》2009,36(3):553-557
Objective: The left atrial appendage is a significant source of cardioembolic thrombi. Open mitral valve surgery presents an opportune time to exclude this appendage from cardiovascular circulation. However, sparse randomized trial support exists for this concomitant procedure. We therefore designed a randomized controlled trial to assess the short- and long-term outcomes of concomitant left atrial appendage exclusion. This report details early outcomes of the pilot trial. Methods: Forty-three patients were randomized to either undergo concomitant suture exclusion of their left atrial appendage under direct vision or not during their open mitral valve surgery. Clinical and biochemical postoperative outcomes, including hemodynamic and hemostatic parameters, were analyzed. Results: There were no deaths in either group. The incidence of cerebrovascular events, myocardial infarction, respiratory failure, and acute renal injury were similar between groups; a composite outcome of 10 major postoperative complications occurred in 32% of the left atrial appendage exclusion group versus 38% of the control group (p = 0.75). Intensive care (median stay 2 days vs 1 day in the control group, p = 0.55) and hospital lengths of stay (median stay 9 days in both groups, p = 0.98) were also similar between groups. Specifically, no additional hemodynamic alterations (need for intra-aortic balloon pump in 1 vs 2 patients in the control group, p = 0.61) or hemostatic complications (no re-operations for bleeding in either group, need for blood product transfusion in 2 vs 1 patient in the control group, p = 1.0) were noted in the left atrial appendage exclusion group. Conclusions: This pilot trial demonstrates the safety of and feasibility of a larger trial powered to detect clinically relevant short- and long-term outcomes of concomitant left atrial appendage exclusion with open mitral valve surgery. 相似文献
10.
Angela Maria Amorini Michele Tuttobene Giuseppe Lazzarino Gabriella Denti 《Trasfusione del sangue》2007,5(1):24-32