全文获取类型
收费全文 | 181篇 |
免费 | 19篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 3篇 |
基础医学 | 18篇 |
口腔科学 | 2篇 |
临床医学 | 10篇 |
内科学 | 104篇 |
皮肤病学 | 2篇 |
神经病学 | 10篇 |
特种医学 | 3篇 |
外科学 | 16篇 |
综合类 | 2篇 |
预防医学 | 5篇 |
眼科学 | 10篇 |
药学 | 7篇 |
肿瘤学 | 7篇 |
出版年
2023年 | 1篇 |
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 5篇 |
2019年 | 8篇 |
2018年 | 7篇 |
2017年 | 11篇 |
2016年 | 12篇 |
2015年 | 12篇 |
2014年 | 20篇 |
2013年 | 22篇 |
2012年 | 9篇 |
2011年 | 7篇 |
2010年 | 3篇 |
2009年 | 8篇 |
2008年 | 14篇 |
2007年 | 6篇 |
2006年 | 6篇 |
2005年 | 9篇 |
2004年 | 7篇 |
2003年 | 9篇 |
2002年 | 8篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 1篇 |
排序方式: 共有200条查询结果,搜索用时 31 毫秒
1.
The plus-strand RNA genome of tomato bushy stunt virus (TBSV) contains a 351-nucleotide (nt)-long 3'-untranslated region. We investigated the role of the 3'-proximal 130 nt of this sequence in viral RNA accumulation within the context of a TBSV defective interfering (DI) RNA. Sequence comparisons between different tombusviruses revealed that the 3' portion of the 130-nt sequence is highly conserved and deletion analysis confirmed that this segment is required for accumulation of DI RNAs in protoplasts. Computer-aided sequence analysis and in vitro solution structure probing indicated that the conserved sequence consists of three stem-loop (SL) structures (5'-SL3-SL2-SL1-3'). The existence of SLs 1 and 3 was also supported by comparative secondary structure analysis of sequenced tombusvirus genomes. Formation of the stem regions in all three SLs was found to be very important, and modification of the terminal loop sequences of SL1 and SL2, but not SL3, decreased DI RNA accumulation in vivo. For SL3, alterations to an internal loop resulted in significantly reduced DI RNA levels. Collectively, these data indicate that all three SLs are functionally relevant and contribute substantially to DI RNA accumulation. In addition, secondary structure analysis of other tombusvirus replicons and related virus genera revealed that a TBSV satellite RNA and members of the closely related genus Aureusvirus (family Tombusviridae) share fundamental elements of this general structural arrangement. Thus, this secondary structure model appears to extend beyond tombusvirus genomes. These conserved 3'-terminal RNA elements likely function in vivo by promoting and/or regulating minus-strand synthesis. 相似文献
2.
3.
Nair Aswin M. Mathew John Goel Ruchika Chebbi Pramod Mathew Ashish Jacob Arvind G. Yadav Bijesh Rebekah Grace Prakash John A. J. Danda Debashish 《Clinical rheumatology》2021,40(7):2805-2819
Clinical Rheumatology - Consensus on treatment of idiopathic inflammatory myositis (IIM), particularly with regard to flares and interstitial lung disease (ILD), does not exist. We studied the... 相似文献
4.
5.
6.
7.
Yogesh Patidar Meena Gupta Geeta A Khwaja Debashish Chowdhury Amit Batra Abhijit Dasgupta 《Annals of Indian Academy of Neurology》2013,16(3):428-431
Apraxia of speech (AOS) is a rare, but well-defined motor speech disorder. It is characterized by irregular articulatory errors, attempts of self-correction and persistent prosodic abnormalities. Similar to aphasia, AOS is also localized to the dominant cerebral hemisphere. We report a case of Crossed Aphasia with AOS in a 48-year-old right-handed man due to an ischemic infarct in right cerebral hemisphere. 相似文献
8.
Yogesh Patidar Meena Gupta Geeta A. Khwaja Debashish Chowdhury Amit Batra Abhijit Dasgupta 《Annals of Indian Academy of Neurology》2013,16(2):157-162
Aims:
To evaluate clinical profile and short-term outcome of psychogenic non-epileptic seizures (PNES) in Indian adult population.Setting and Design:
A prospective observational study, conducted at tertiary teaching institute at New Delhi.Materials and Methods:
Sixty-three patients with confirmed PNES were enrolled. The diagnosis was based on witnessing the event during video-electroencephalography (Video-EEG) monitoring. A detailed clinical evaluation was done including evaluation for coexistent anxiety or depressive disorders. Patients were divided into two groups on the basis of excessive or paucity of movements during PNES attacks. Patients were followed-up to 12 months for their PNES frequency.Statistical Analysis:
Means and standard deviations were calculated for continuous variables. Chi-square and Students t-test were used to compare categorical and continuous variables respectively.Results:
The mean age at onset of PNES was 25.44 years; with F:M ratio of 9.5:1. Coexistent epilepsy was present in 13 (20.63%) cases. Twenty-two patients (44%) with only PNES (n = 50) had received antiepileptic drugs. Out of 63 patients of PNES 24 (38.1%) had predominant motor phenomenon, whereas 39 (61.9%) had limp attacks. The common features observed were pre-ictal headache, ictal eye closure, jaw clenching, resistant behavior, ictal weeping, ictal vocalization, and unresponsiveness during episodes. Comorbid anxiety and depressive disorders was seen in 62.3% and 90.16% patients, respectively. Short-term (6-12 months) outcome of 45 patients was good (seizure freedom in 46.66% and >50% improvement in 24.44% cases).Conclusion:
PNES is common, but frequently misdiagnosed and treated as epileptic seizures. A high index of suspicion is required for an early diagnosis. Proper disclosure of diagnosis and management of the psychiatric comorbidities can improve their outcome.Limitation:
Limited sample size and change in seizures frequency as the only parameter for the assessment of the outcome are the two major limitations of our study. 相似文献9.
10.
Uday?C?GhoshalEmail author Debashish?Guha Santu?Bandyopadhyay Chiranjib?Pal Srikanta?Chakraborty Ujjala?Ghoshal Tamal?K?Ghosh Bhaskar?B?Pal Prabir?K?Banerjee 《BMC gastroenterology》2002,2(1):6