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排序方式: 共有169条查询结果,搜索用时 15 毫秒
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Hauber HP Gotfried M Newman K Danda R Servi RJ Christodoulopoulos P Hamid Q 《The Journal of allergy and clinical immunology》2003,112(1):58-63
BACKGROUND: New hydrofluoroalkane (HFA) formulations of glucocorticoids have been shown to effectively control asthma. HFA glucocorticoids are deposited across all sizes of airways, including the small ones. However, it is not clear whether they can suppress peripheral airway inflammation. OBJECTIVE: We sought to determine whether HFA-flunisolide could suppress peripheral inflammation in asthma. METHODS: Twelve patients with mild to moderate asthma received HFA-flunisolide for 6 weeks. Transbronchial and endobronchial biopsy specimens were obtained before and after treatment, and spirometry was performed. Changes in inflammatory cells (eosinophils, neutrophils, lymphocytes, macrophages, basophils) and IL-5 and eotaxin were measured by using immunocytochemistry and in situ hybridization. RESULTS: Lung function significantly improved after treatment (P <.05). HFA-flunisolide significantly reduced eosinophils, IL-5, and eotaxin in both peripheral and central airways (P <.01). Neutrophils significantly increased after treatment in peripheral and central airways (P <.05). The numbers of lymphocytes remained unchanged. CONCLUSIONS: These results show that HFA-flunisolide effectively suppressed eosinophilic inflammation in peripheral and central airways. These changes were accompanied by improvement in lung function. 相似文献
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Nair Aswin M. Mathew John Goel Ruchika Chebbi Pramod Mathew Ashish Jacob Arvind G. Yadav Bijesh Rebekah Grace Prakash John A. J. Danda Debashish 《Clinical rheumatology》2021,40(7):2805-2819
Clinical Rheumatology - Consensus on treatment of idiopathic inflammatory myositis (IIM), particularly with regard to flares and interstitial lung disease (ILD), does not exist. We studied the... 相似文献
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Gandham SriLakshmi Bhavani Hitesh Shah Ashwin B. Dalal Anju Shukla Sumita Danda Shagun Aggarwal Shubha R. Phadke Neerja Gupta Madhulika Kabra Kalpana Gowrishankar Anju Gupta Meenakshi Bhat Ratna D. Puri Sunita Bijarnia‐Mahay Sheela Nampoothiri Kavitha M. Mohanasundaram S. Rajeswari Akhil M. Kulkarni Muralidhar L. Kulkarni Prajnya Ranganath A. Radha Ramadevi Sankar V. Hariharan Katta Mohan Girisha 《American journal of medical genetics. Part A》2015,167(10):2481-2484
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Danda Sumita Mohan Sony Devaraj Prabavathi Dutta Atanu K. Nampoothiri Sheela Yesodharan Dhanya Phadke Shubha R. Jalan Anil B. Thangaraj K. Verma Ishwar Chandra Danda Debashish Jebaraj Isaac 《Clinical rheumatology》2020,39(9):2743-2749
Clinical Rheumatology - Alkaptonuria (AKU) is a rare metabolic disease. The global incidence is 1:100,000 to 1:250,000. However, identification of a founder mutation in a gypsy population from... 相似文献
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Gertken JT Cocjin J Pehlivanov N Danda C Hyman PE 《Journal of pediatric gastroenterology and nutrition》2005,41(3):328-331
BACKGROUND: In children with prolonged constipation of unclear pathogenesis or unresponsive to treatment, colon manometry can discriminate between functional fecal retention (FFR) and colon neuromuscular diseases. AIM: To identify the clinical features precipitating referral for colon manometry in children with functional constipation. METHOD: Retrospective medical record review of 173 constipated children (116 male, mean age 6.9 years, range 1-17 years) referred for colon manometry. RESULTS: Manometry was normal in 121 (70%). In those with normal manometry, FFR was identified in 96, irritable bowel syndrome (IBS) in 10, and functional constipation in 15. Of the 96 children FFR, 72 (76%) had comorbid conditions that might have interfered with the clinician's ability to diagnose FFR. Of 52 children with colon neuromuscular disease, only 12 (23%) had comorbid conditions (P < 0.001 compared with FFR). Of children more than 4 years, those with FFR were more likely to have fecal incontinence (44 of 62; 71%) than those with other functional disorders (2 of 19; 10%; P < 0.001) or neuromuscular disease (6 of 23; 26%; P < 0.001). CONCLUSIONS: Two thirds of children referred for colon manometry had normal studies and met criteria for a functional diagnosis. Three quarters of those with functional constipation had a comorbid condition that might alter the history sufficiently to obscure the diagnosis. 相似文献