全文获取类型
收费全文 | 3909篇 |
免费 | 596篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 133篇 |
妇产科学 | 228篇 |
基础医学 | 363篇 |
口腔科学 | 36篇 |
临床医学 | 1379篇 |
内科学 | 592篇 |
皮肤病学 | 46篇 |
神经病学 | 270篇 |
特种医学 | 80篇 |
外科学 | 358篇 |
综合类 | 61篇 |
一般理论 | 1篇 |
预防医学 | 410篇 |
眼科学 | 23篇 |
药学 | 239篇 |
中国医学 | 3篇 |
肿瘤学 | 269篇 |
出版年
2023年 | 71篇 |
2022年 | 25篇 |
2021年 | 68篇 |
2020年 | 63篇 |
2019年 | 45篇 |
2018年 | 132篇 |
2017年 | 145篇 |
2016年 | 137篇 |
2015年 | 149篇 |
2014年 | 164篇 |
2013年 | 175篇 |
2012年 | 185篇 |
2011年 | 187篇 |
2010年 | 158篇 |
2009年 | 145篇 |
2008年 | 151篇 |
2007年 | 177篇 |
2006年 | 154篇 |
2005年 | 156篇 |
2004年 | 118篇 |
2003年 | 130篇 |
2002年 | 115篇 |
2001年 | 105篇 |
2000年 | 96篇 |
1999年 | 129篇 |
1998年 | 73篇 |
1997年 | 88篇 |
1996年 | 85篇 |
1995年 | 69篇 |
1994年 | 59篇 |
1993年 | 56篇 |
1992年 | 82篇 |
1991年 | 68篇 |
1990年 | 87篇 |
1989年 | 67篇 |
1988年 | 56篇 |
1987年 | 55篇 |
1986年 | 44篇 |
1985年 | 43篇 |
1984年 | 29篇 |
1983年 | 22篇 |
1981年 | 28篇 |
1979年 | 35篇 |
1978年 | 21篇 |
1977年 | 19篇 |
1976年 | 20篇 |
1975年 | 22篇 |
1974年 | 24篇 |
1973年 | 18篇 |
1970年 | 18篇 |
排序方式: 共有4517条查询结果,搜索用时 22 毫秒
1.
Dalton Luiz Schiessel Ricardo K. Yamazaki Marcelo Kryczyk Isabela Coelho de Castro Adriana A. Yamaguchi Danielle C. T. Pequito 《Nutrition and cancer》2016,68(8):1369-1380
Objective: Polyunsaturated fatty acids n-3 (PUFA n-3) have shown effects in reducing tumor growth, in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) abundantly present in fish oil (FO). When these fatty acids are provided in the diet, they alter the functions of the cells, particularly in tumor and immune cells. However, the effects of α-linolenic fatty acid (ALA), which is the precursor of EPA and DHA, are controversial. Thus, our objective was to test the effect of this parental fatty acid. Methods: Non-tumor-bearing and tumor-bearing Wistar rats (70 days) were supplemented with 1 g/kg body weight of FO or Oro Inca® (OI) oil (rich in ALA). Immune cells function, proliferation, cytokine production, and subpopulation profile were evaluated. Results: We have shown that innate immune cells enhanced phagocytosis capacity, and increased processing and elimination of antigens. Moreover, there was a decrease in production of pro-inflammatory cytokines (tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6)) by macrophages. Lymphocytes showed decreased proliferation capacity, increased cluster of differentiation 8 (CD8+) subpopulation, and increased TNF-α production. Conclusions: Oil rich in ALA caused similar immune modulation in cancer when compared with FO. 相似文献
2.
3.
Fluid role boundaries: exploring the contribution of the advanced nurse practitioner to multi‐professional palliative care
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
4.
W. Dalton Dietrich 《Topics in spinal cord injury rehabilitation》2015,21(2):174-187
It was an honor for me to present the 2014 G. Heiner Sell Memorial Lecture at the annual American Spinal Injury Association (ASIA) meeting in San Antonio. For this purpose, I provided a comprehensive review of the scope of research targeting discovery and translational and clinical investigations into spinal cord injury (SCI) research. Indeed, these are exciting times in the area of spinal cord research and clinical initiatives. Many laboratories and clinical programs throughout the world are publishing data related to the pathophysiology of SCI and new strategies for protecting and promoting recovery in both animal models and humans. For this lecture, several topics were discussed including neuroprotective and reparative strategies, neurorehabilitation, quality of life issues, and future directions. In the area of neuroprotection, pathophysiological events that may be targeted with therapeutic strategies, including pharmacological and targeted temperature management were reviewed. For reparative approaches, the importance of both intrinsic and extrinsic mechanisms of axonal regeneration was highlighted. Various cell therapies currently being tested in preclinical and clinical arenas were reviewed as well as ongoing US Food and Drug Administration approved trials for SCI patients. Neurorehabilitation is an evolving research field with locomotive training strategies, electrical stimulation, and brain-machine interface programs targeting various types of SCI. The importance of testing combination approaches including neuroprotective, reparative, and rehabilitative strategies to maximize recovery mechanisms was therefore emphasized. Finally, quality of life issues that affect thousands of individuals living with paralysis were also presented. Future directions and specific obstacles that require attention as we continue to move the SCI field forward were discussed. 相似文献
5.
6.
MR compatibility of Guglielmi detachable coils 总被引:6,自引:0,他引:6
7.
BEVERLY HAVENS RN MN MPH INGRID SWENSON RN DPH 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1986,15(5):406-411
Seventy-four 8th- and 10th-grade students attending a private girls' school in Hawaii were queried about their perceptions of and preparation for menstruation using a questionnaire administered in a health education class. Eighty percent had already started menstruating. The most frequently cited perceptions by the respondents referred to both the inconveniences and the normalcy of menstruation. Many were first informed about menstruation by their mothers and stated that they also first informed their mothers when they started menstruating. Surprise, fear, and embarrassment were common initial reactions, while strong negative or positive emotions were more rare. Only 35% wanted boys and girls together during class discussion, but 89% stated that boys needed to be informed about menstruation. The most frequent reasons cited for noncoed settings were the girls' concern about their comfort in openly discussing menstruation. Thirty-eight percent thought parents should inform other siblings when they started menstruation, although almost half gave specific conditions the parents should consider. The majority thought the fifth to sixth grades were the best times to introduce menstruation content. 相似文献
8.
Alan Willmore Tim Sladden Lucy Bates Craig B Dalton 《International journal of health geographics》2006,5(1):30-14
Background
To determine patterns of childhood lead exposure in a community living near a lead and zinc smelter in North Lake Macquarie, Australia between 1991 and 2002. 相似文献9.
AIM: To undertake a systematic review of the diagnostic performance of clinical examination, sample acquisition and sample analysis in infected foot ulcers in diabetes. METHODS: Nineteen electronic databases plus other sources were searched. To be included, studies had to fulfil the following criteria: (i) compare a method of clinical assessment, sample collection or sample analysis with a reference standard; (ii) recruit diabetic individuals with foot ulcers; (ii) present 2 x 2 diagnostic data. Studies were critically appraised using a 12-item checklist. RESULTS: Three eligible studies were identified, one each on clinical examination, sample collection and sample analysis. For all three, study groups were heterogeneous with respect to wound type and a small proportion of participants had foot ulcers due to diabetes. No studies identified an optimum reference standard. Other methodological problems included non-blind interpretation of tests and the time lag between index and reference tests. Individual signs or symptoms of infection did not prove to be useful tests when assessed against punch biopsy as the reference standard. The wound swab did not perform well when assessed against tissue biopsy. Semiquantitative analysis of wound swab might be a useful alternative to quantitative analysis. The limitations of these findings and their impact on recommendations from relevant clinical guidelines are discussed. CONCLUSION: Given the importance of this topic, it is surprising that only three eligible studies were identified. It was not possible to describe the optimal methods of diagnosing infection in diabetic patients with foot ulceration from the evidence identified in this systematic review. 相似文献
10.