全文获取类型
收费全文 | 1647篇 |
免费 | 116篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 58篇 |
妇产科学 | 56篇 |
基础医学 | 184篇 |
口腔科学 | 59篇 |
临床医学 | 163篇 |
内科学 | 390篇 |
皮肤病学 | 40篇 |
神经病学 | 107篇 |
特种医学 | 53篇 |
外国民族医学 | 1篇 |
外科学 | 165篇 |
综合类 | 14篇 |
一般理论 | 1篇 |
预防医学 | 131篇 |
眼科学 | 82篇 |
药学 | 155篇 |
中国医学 | 5篇 |
肿瘤学 | 94篇 |
出版年
2023年 | 16篇 |
2022年 | 60篇 |
2021年 | 101篇 |
2020年 | 57篇 |
2019年 | 80篇 |
2018年 | 78篇 |
2017年 | 41篇 |
2016年 | 60篇 |
2015年 | 54篇 |
2014年 | 91篇 |
2013年 | 103篇 |
2012年 | 128篇 |
2011年 | 128篇 |
2010年 | 67篇 |
2009年 | 56篇 |
2008年 | 66篇 |
2007年 | 84篇 |
2006年 | 68篇 |
2005年 | 74篇 |
2004年 | 67篇 |
2003年 | 60篇 |
2002年 | 41篇 |
2001年 | 22篇 |
2000年 | 19篇 |
1999年 | 16篇 |
1998年 | 12篇 |
1997年 | 14篇 |
1996年 | 7篇 |
1995年 | 8篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1992年 | 8篇 |
1990年 | 5篇 |
1988年 | 4篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 2篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 3篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 7篇 |
1972年 | 3篇 |
1971年 | 2篇 |
1968年 | 2篇 |
1966年 | 3篇 |
排序方式: 共有1775条查询结果,搜索用时 31 毫秒
1.
Dalia Magaña 《Health communication》2020,35(5):649-657
ABSTRACTThis study closely examines 51 breast cancer narratives Latina and Spanish women wrote for other patients to illuminate how they conceptualize their health, with insights for addressing health disparities. Using discourse analysis of the role of language and culture in health care communication, this study focuses on the use of metaphors in the narratives. This provides revelations about the cultural and linguistic aspects of how the writers conceptualize their disease. Building on past research on metaphor use in cancer discourse in the English language, this study reveals the prevalence of metaphors comparing cancer to combat, or more generally, violence (e.g., “my battle against cancer”), or a journey (e.g., “my path with cancer”). Writers used this metaphorical language to offer advice to others with cancer and to mark their membership in a larger community of people with cancer. We also find that Spanish women use metaphors more frequently than Latinas and that they differed in their metaphorical portrayals of cancer. This research uncovers culturally embedded themes that are central to how women with cancer think about the disease, such as the prominence of spirituality in Latinas’ metaphorical constructions, a pattern not evident in Spanish women’s narratives. 相似文献
2.
Mahmoud R Hussein Dalia A Elsers Sabah A Fadel Abd-Elhady M Omar 《European journal of cancer prevention》2006,15(1):64-68
Although melanocytic skin lesions have been recognized since antiquity, their literature was limited to Caucasians. To date, the clinicopathologic features of these lesions in Egyptians are still unknown. To define these features, diagnostic records of the melanocytic skin lesions received at the Pathology Department, Assuit University Hospitals (1989-2004) were reviewed. The lesions examined included 12 benign naevi (BN), 10 dysplastic naevi (DN), and 21 cutaneous malignant melanomas (CMMs). The DN and CMMs were more common in men than in women (2 : 1 and 1.5 : 1, respectively) while BN were more common in women (2 : 1). The average age incidence was 33+/-5, 38+/-7 and 54+/-3 years, for BN, DN and CMM, respectively. The lower limb (13/21, 62%), head and neck (7/21, 33%) were the most common sites for CMMs. The average size (mm) was 2+/-0.3, 4+/-0.6 and 21+/-0.3 for BN, DN and CMMs, respectively. Recurrence occurred in 10% of CMMs. Histologically, CMMs were of nodular type and composed of epithelioid (7/21, 33%), spindle cells (1/21, 5%), or mixed cells (13/21, 62%). The mean tumour thickness (Breslow) was 6+/-0.5 mm. CMMs included two of 21(9%), three of 21(14%), six of 21(38%), and 10 of 21(38%) with Clark level II, III, IV and V. In Egypt, CMM is the third most common cutaneous neoplasm following squamous and basal cell carcinomas. Compared with Western societies, melanoma has a male sex predilection, similar histological features but different topographical distribution and rare incidence. The striking difference from Western series is the incidence of nodular melanoma - in the West this represents 15-30% of melanomas, with superficial spreading being the majority. Another key difference from the West is the 'sun-bed' culture of the West and the desire to have suntans. This is the first study that reports the clinicopathologic features of melanocytic skin lesions in Egypt. 相似文献
3.
4.
Daphna Oyserman PhD Rami Benbenishty PhD Dalia Ben-Rabi MSW 《Child psychiatry and human development》1992,22(3):199-211
This study provides an overview of children, their families, and their circumstances at the time that the child entered foster care in Israel. Data regarding a representative sample of 800 children were collected as part of the ongoing operation of a clinical information system set up for Israel's foster care service in 1988. Implications of our findings for interventions are discussed. 相似文献
5.
6.
Beeri Rachel; Gnatt Averell; Lapidot-Lifson Yaron; Ginzberg Dalia; Shani Moshe; Soreq Hermona; Zakut Haim 《Human reproduction (Oxford, England)》1994,9(2):284-292
Gene amplification occurs frequently in tumour tissues yet is,in general, non-inheritable. To study the molecular mechanismsconferring this restraint, we created transgenic mice carryinga human butyrylcholinesterase (BCHE) coding sequence, previouslyfound to be amplified in a father and son. Blot hybridizationof tail DNA samples revealed somatic transgene amplificationswith variable restriction patterns and intensities, suggestingthe occurrence of independent amplification events, in 31% (11/35)of mice from the FII generation but in only 3.5% (2/58) of theFII and FIV generations. In contrast, >10-fold amplificationsof the BCHE transgene and the endogenous acetylcholinesteraseand c-raf genes appeared in both testis and epididymis DNA from>80% of FIII mice. Drastic, selective reductions in testisBCHEmRNA but not in actin mRNA were detected by the PCR amplificationof testis cDNA from the transgenic mice, and apparently resultedin the limited transmission of amplified genes. The testicularamplification of the BCHE transgene may potentially representa general phenomenon with clinical implications in human infertility. 相似文献
7.
8.
Expression of luminal and basal cytokeratins in human breast carcinoma 总被引:32,自引:0,他引:32
Abd El-Rehim DM Pinder SE Paish CE Bell J Blamey RW Robertson JF Nicholson RI Ellis IO 《The Journal of pathology》2004,203(2):661-671
We have examined basal and luminal cell cytokeratin expression in 1944 cases of invasive breast carcinoma, using tissue microarray (TMA) technology, to determine the frequency of expression of each cytokeratin subtype, their relationships and prognostic relevance, if any. Expression was determined by immunocytochemistry staining using antibodies to the luminal cytokeratins (CKs) 7/8, 18 and 19 and the basal markers CK 5/6 and CK 14. Additionally, assessment of alpha-smooth muscle actin (SMA) and oestrogen receptor status (ER) was performed. The vast majority of the cases showed positivity for CK 7/8, 18 and 19 indicating a differentiated glandular phenotype, a finding associated with good prognosis, ER positivity and older patient age. In contrast, basal marker expression was significantly related to poor prognosis, ER negativity and younger patient age. Multivariate analysis showed that CK 5/6 was an independent indicator for relapse free interval. We were able to subgroup the cases into four distinct phenotype categories (pure luminal, mixed luminal/basal, pure basal and null), which had significant differences in relation to the biological features and the clinical course of the disease. Tumours classified as expressing a basal phenotype (the combined luminal plus basal and the pure basal) were in a poor prognostic subgroup, typically ER negative in most cases. These findings provide further evidence that breast cancer has distinct differentiation subclasses that have both biological and clinical relevance. 相似文献
9.
Omran F. Osman Linda Oskam Nel C. M. Kroon Gerard J. Schoone El-Tahir A. G. Khalil Ahmed M. El-Hassan Ed E. Zijlstra Piet A. Kager 《Journal of clinical microbiology》1998,36(6):1621-1624
Microscopy and PCR were compared for use in the diagnosis of post-kala-azar dermal leishmaniasis (PKDL) in 63 patients. Aspirates of lymph nodes (samples from 52 patients), skin (23 samples), and bone marrow (18 samples) were used. For 11 patients lymph node aspiration could be repeated 6 months after they recovered from PKDL. During active PKDL, PCR was positive for 42 of 52 (80.8%) lymph node aspirates and 19 of 23 (82.7%) skin aspirates, whereas microscopy was positive for only 9 of 52 (17.3%) lymph node aspirates and 7 of 23 (30.4%) skin aspirates. PCR was always positive when parasites were seen by microscopy. When the results obtained with lymph node and skin aspirates from the same patient (n = 16) were compared, there was complete agreement. Bone marrow samples were negative by microscopy and PCR for 16 patients and positive by both methods for 1 patient; for one sample only the PCR was positive. PCR confirmed the co-occurrence of visceral leishmaniasis and PKDL in one patient and confirmed the suspicion of this co-occurrence in the other patient. After recovery, no parasites were found by microscopy, but 2 of 11 (18.2%) samples were still positive by PCR. Thirty negative controls were all found to be PCR negative, and 15 positive controls were all PCR positive. Cross-reactions with Mycobacterium leprae could be ruled out. In conclusion, PCR with inguinal lymph node or skin aspirates is suitable for confirming the clinical diagnosis of PKDL. In some patients, lymph node aspirates are probably preferred because aspiration of material from the skin may leave scars. 相似文献
10.
Summary Monkey interferon (MKIF) produced in monkey BSC-1 cells infected with Newcastle disease virus showed antiviral activity on human foreskin fibroblasts and RD114 cells—a human line transformed by feline sarcoma virus. The titer of the monkey interferon in human cells was 10–30 fold greater than that found in several normal monkey (BSC-1, CV-1) or SV40 transformed (C2, C6, T-22) monkey cell lines tested. Ten to fifteen-fold purification of MKIF without loss of activity could be achieved by chromatography on Phenyl-Sepharose CL-4B. Antiviral activity of MKIF was fully resistant to treatment with 1 per cent sodium dodecyl sulfate (SDS).With 1 Figure 相似文献