全文获取类型
收费全文 | 1482篇 |
免费 | 191篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 54篇 |
妇产科学 | 34篇 |
基础医学 | 126篇 |
口腔科学 | 40篇 |
临床医学 | 214篇 |
内科学 | 336篇 |
皮肤病学 | 110篇 |
神经病学 | 62篇 |
特种医学 | 135篇 |
外科学 | 200篇 |
综合类 | 94篇 |
现状与发展 | 30篇 |
预防医学 | 61篇 |
眼科学 | 20篇 |
药学 | 59篇 |
中国医学 | 3篇 |
肿瘤学 | 89篇 |
出版年
2024年 | 14篇 |
2023年 | 178篇 |
2022年 | 15篇 |
2021年 | 16篇 |
2020年 | 57篇 |
2019年 | 24篇 |
2018年 | 51篇 |
2017年 | 52篇 |
2016年 | 43篇 |
2015年 | 59篇 |
2014年 | 85篇 |
2013年 | 65篇 |
2012年 | 33篇 |
2011年 | 37篇 |
2010年 | 82篇 |
2009年 | 93篇 |
2008年 | 34篇 |
2007年 | 62篇 |
2006年 | 44篇 |
2005年 | 30篇 |
2004年 | 22篇 |
2003年 | 22篇 |
2002年 | 22篇 |
2001年 | 18篇 |
2000年 | 25篇 |
1999年 | 32篇 |
1998年 | 36篇 |
1997年 | 49篇 |
1996年 | 42篇 |
1995年 | 35篇 |
1994年 | 29篇 |
1993年 | 34篇 |
1992年 | 12篇 |
1991年 | 12篇 |
1990年 | 11篇 |
1989年 | 23篇 |
1988年 | 23篇 |
1987年 | 14篇 |
1986年 | 8篇 |
1985年 | 14篇 |
1984年 | 6篇 |
1983年 | 9篇 |
1982年 | 9篇 |
1981年 | 10篇 |
1980年 | 13篇 |
1978年 | 10篇 |
1976年 | 18篇 |
1975年 | 18篇 |
1974年 | 7篇 |
1972年 | 7篇 |
排序方式: 共有1693条查询结果,搜索用时 15 毫秒
1.
A mixed‐method study of effects of a therapeutic play intervention for children on parental anxiety and parents' perceptions of the intervention 下载免费PDF全文
2.
Ewelina Kazimierczyk Andrzej Eljaszewicz Paula Zembko Ewa Tarasiuk Malgorzata Rusak Agnieszka Kulczynska-Przybik Marta Lukaszewicz-Zajac Karol Kaminski Barbara Mroczko Maciej Szmitkowski Milena Dabrowska Bozena Sobkowicz Marcin Moniuszko Agnieszka Tycinska 《Pharmacological reports : PR》2019,71(1):73-81
Background
Acute myocardial infarction (AMI) causes irreversible myocardial damage and release of inflammatory mediators, including cytokines, chemokines and miRNAs. We aimed to investigate changes in the levels of cytokines (IL-6, TNF-α and IL-10), miRNAs profiles (miR-146 and miR-155) and distribution of different monocyte subsets (CD14++CD16-, CD14++CD16+, CD14+CD16++) in the acute and post-healing phases of AMI.Methods
In eighteen consecutive AMI patients (mean age 56.78?±?12.4 years, mean left ventricle ejection fraction – LVEF: 41.9?±?9.8%), treated invasively, monocyte subsets frequencies were evaluated (flow cytometry), cytokine concentrations were analyzed (ELISA) as well as plasma miRNAs were isolated twice – on admission and after 19.2?±?5.9 weeks of follow-up. Measurements were also performed among healthy volunteers.Results
AMI patients presented significantly decreased frequencies of classical cells in comparison to healthy controls (median 71.22% [IQR: 64.4–79.04] vs. 84.35% [IQR: 81.2–86.7], p?=?0.001) and higher percent of both intermediate and non-classical cells, yet without statistical significance (median 6.54% [IQR: 5.14–16.64] vs. 5.87% [IQR: 4.48–8.6], p?=?0.37 and median 5.99% [IQR: 3.39–11.5] vs. 5.26% [IQR: 3.62–6.2], p?=?0.42, respectively). In AMI patients both, analyzed plasma miRNA concentrations were higher than in healthy subjects (miR-146: median 5.48 [IQR: 2.4–11.27] vs. 1.84 [IQR: 0.87–2.53], p?=?0.003; miR-155: median 25.35 [IQR: 8.17–43.15] vs. 8.4 [IQR: 0.08–16.9], p?=?0.027, respectively), and returned back to the values found in the control group in follow-up. miR-155/miR-146 ratio correlated with the frequencies of classical monocytes (r=0.6, p?=?0.01) and miR-155 correlated positively with the concentration of inflammatory cytokines ? IL-6 and TNF-α.Conclusions
These results may suggest cooperation of both pro-inflammatory and anti-inflammatory signals in AMI in order to promote appropriate healing of the infarcted myocardium. 相似文献3.
Hysterosalpingography was performed in 31 patients by means of a low-dose scanning-beam digital radiographic system. The technique permits adequate evaluation of gynecologic abnormalities while allowing significant reduction in radiation: 2.4-mR (6.1 X 10(-7) C/kg) exposure to the skin and 0.7-mrad (7 X 10(-6) Gy) mean dose to the ovaries per image obtained. Sixteen patients demonstrated readily recognizable and documented abnormalities, corroborated by laparoscopy, laparotomy, or other supportive evidence. 相似文献
4.
5.
6.
7.
8.
Solitary bronchioloalveolar carcinoma: CT criteria 总被引:14,自引:0,他引:14
Kuhlman JE; Fishman EK; Kuhajda FP; Meziane MM; Khouri NF; Zerhouni EA; Siegelman SS 《Radiology》1988,167(2):379-382
The computed tomographic (CT) scans of 30 patients with solitary bronchioloalveolar carcinoma were reviewed. Common features at CT included the peripheral or subpleural location of a pulmonary mass (25 cases), pseudocavitation (18 cases), heterogeneous attenuation (17 cases), irregular margins forming a star pattern (22 cases), and pleural tags (21 cases). Using these CT criteria, four independent observers attempted to identify cases of bronchioloalveolar carcinoma from a larger sample of lung cancers and benign lesions by categorizing a series of test cases into four probability categories. Although the bronchioloalveolar carcinomas were correctly ranked in the two highest probability categories 75% of the time (in 45 of 60 cases), there was considerable overlap with other lung lesions, particularly with adenocarcinoma and large cell undifferentiated carcinoma. However, even though the typical features of bronchioloalveolar carcinoma are not invariable or highly specific, they are characteristic enough to suggest the diagnosis. 相似文献
9.
10.
Roderik Metz Gino MMJ Kerkhoffs Egbert-Jan MM Verleisdonk Geert J van der Heijden 《BMC musculoskeletal disorders》2007,8(1):108