全文获取类型
收费全文 | 63644篇 |
免费 | 5619篇 |
国内免费 | 3566篇 |
专业分类
耳鼻咽喉 | 644篇 |
儿科学 | 718篇 |
妇产科学 | 750篇 |
基础医学 | 8104篇 |
口腔科学 | 1316篇 |
临床医学 | 7606篇 |
内科学 | 9918篇 |
皮肤病学 | 864篇 |
神经病学 | 3512篇 |
特种医学 | 2742篇 |
外国民族医学 | 38篇 |
外科学 | 7326篇 |
综合类 | 8779篇 |
现状与发展 | 7篇 |
一般理论 | 3篇 |
预防医学 | 4034篇 |
眼科学 | 1744篇 |
药学 | 6342篇 |
49篇 | |
中国医学 | 2955篇 |
肿瘤学 | 5378篇 |
出版年
2024年 | 157篇 |
2023年 | 836篇 |
2022年 | 2339篇 |
2021年 | 3192篇 |
2020年 | 2121篇 |
2019年 | 2006篇 |
2018年 | 2169篇 |
2017年 | 1862篇 |
2016年 | 1998篇 |
2015年 | 2905篇 |
2014年 | 3542篇 |
2013年 | 3261篇 |
2012年 | 5115篇 |
2011年 | 5267篇 |
2010年 | 3396篇 |
2009年 | 2778篇 |
2008年 | 3568篇 |
2007年 | 3447篇 |
2006年 | 3217篇 |
2005年 | 2939篇 |
2004年 | 2287篇 |
2003年 | 2213篇 |
2002年 | 1989篇 |
2001年 | 1613篇 |
2000年 | 1500篇 |
1999年 | 1333篇 |
1998年 | 721篇 |
1997年 | 755篇 |
1996年 | 586篇 |
1995年 | 493篇 |
1994年 | 410篇 |
1993年 | 292篇 |
1992年 | 403篇 |
1991年 | 309篇 |
1990年 | 271篇 |
1989年 | 235篇 |
1988年 | 194篇 |
1987年 | 175篇 |
1986年 | 141篇 |
1985年 | 142篇 |
1984年 | 79篇 |
1983年 | 68篇 |
1982年 | 38篇 |
1981年 | 32篇 |
1979年 | 50篇 |
1978年 | 30篇 |
1975年 | 31篇 |
1974年 | 39篇 |
1973年 | 37篇 |
1971年 | 33篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Journal of Behavioral Medicine - Evidence supports the use of graphic warnings to educate the public about the health harms of smoking and suggests warnings eliciting negative emotional responses... 相似文献
2.
Feng Song Li Ruipiao Wang Zhiying 《Odontology / the Society of the Nippon Dental University》2022,110(3):508-522
Odontology - To investigate the characterization and function of a novel porous osteogenic material (PLLA / DDM) containing polylactic acid and demineralized dentin matrix. The surface morphology... 相似文献
3.
4.
Wang-Shu Zhu Si-Ya Shi Ze-Hong Yang Chao Song Jun Shen 《World journal of gastroenterology : WJG》2020,26(11):1208-1220
BACKGROUND Postoperative liver failure is the most severe complication in cirrhotic patients with hepatocellular carcinoma(HCC) after major hepatectomy. Current available clinical indexes predicting postoperative residual liver function are not sufficiently accurate.AIM To determine a radiomics model based on preoperative gadoxetic acid-enhanced magnetic resonance imaging for predicting liver failure in cirrhotic patients with HCC after major hepatectomy.METHODS For this retrospective study, a radiomics-based model was developed based on preoperative hepatobiliary phase gadoxetic acid-enhanced magnetic resonance images in 101 patients with HCC between June 2012 and June 2018. Sixty-one radiomic features were extracted from hepatobiliary phase images and selected by the least absolute shrinkage and selection operator method to construct a radiomics signature. A clinical prediction model, and radiomics-based model incorporating significant clinical indexes and radiomics signature were built using multivariable logistic regression analysis. The integrated radiomics-based model was presented as a radiomics nomogram. The performances of clinical prediction model, radiomics signature, and radiomics-based model for predicting post-operative liver failure were determined using receiver operating characteristics curve, calibration curve, and decision curve analyses.RESULTS Five radiomics features from hepatobiliary phase images were selected to construct the radiomics signature. The clinical prediction model, radiomics signature, and radiomics-based model incorporating indocyanine green clearance rate at 15 min and radiomics signature showed favorable performance for predicting postoperative liver failure(area under the curve: 0.809-0.894). The radiomics-based model achieved the highest performance for predicting liver failure(area under the curve: 0.894; 95%CI: 0.823-0.964). The integrated discrimination improvement analysis showed a significant improvement in the accuracy of liver failure prediction when radiomics signature was added to the clinical prediction model(integrated discrimination improvement = 0.117, P =0.002). The calibration curve and an insignificant Hosmer-Lemeshow test statistic(P = 0.841) demonstrated good calibration of the radiomics-based model. The decision curve analysis showed that patients would benefit more from a radiomics-based prediction model than from a clinical prediction model and radiomics signature alone.CONCLUSION A radiomics-based model of preoperative gadoxetic acid–enhanced MRI can be used to predict liver failure in cirrhotic patients with HCC after major hepatectomy. 相似文献
5.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
6.
皮肤损伤后的异常愈合会导致病理性瘢痕的产生。病理性瘢痕的出现不仅影响美观,严重时还会造成心理和生理功能障碍。病理性瘢痕的机制研究对于瘢痕治疗有极为重要的意义。其中,动物瘢痕模型是目前研究病理性瘢痕的重要模型手段之一。理想的动物瘢痕模型应该在组织学、细胞学等层面尽可能接近于人类的病理性瘢痕。该文分别从传统技术动物瘢痕中的啮齿类动物模型、兔耳模型和猪模型,以及新技术动物瘢痕模型这两个方面,结合近年来在瘢痕领域应用较多的研究,进行了相应系统的阐述。 相似文献
7.
利用空间频域成像技术搭建的成像系统检测多种皮肤病组织的光学参数和生理参数信息,并对比分析讨论不同类型的皮肤病与光学参数、生理参数之间的关系。实验结果表明,病变皮肤组织与正常皮肤组织之间在光学参数、生理参数上存在较大差异,这将为临床医生对皮肤病诊治提供一种新颖、可靠、科学的评估方法。 相似文献
8.
9.
Sophocarpine attenuates toll‐like receptor 4 in steatotic hepatocytes to suppress pro‐inflammatory cytokines synthesis
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
10.