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排序方式: 共有130条查询结果,搜索用时 234 毫秒
1.
RECURRING POSTOPERATIVE PYODERMA GANGRENOSUM 总被引:1,自引:0,他引:1
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ERNOUF DOMINIQUE; DAOUST MARTINE; POULAIN DOMINIQUE; NARCISSE GUY 《Alcohol and alcoholism (Oxford, Oxfordshire)》1992,27(3):273-276
Triptosine is a new L-5-hydroxytryptophan derivative whose effecthas been studied in the Long-Evans alcohol-preferring rat. Atan oral dose of 100 mg/kg once daily, triptosine reduced alcoholconsumption by 42% in the second week of treatment and increasedthat of water by 80%. The results suggest that this precursorof serotonin might play an important role in diminishing preferencefor alcohol and reaccustoming the animal to water, without exertingan anorexic effect. 相似文献
4.
In vivo treatment with recombinant IL-12 protects C57BL/6J mice against secondary alveolar echinococcosis 总被引:1,自引:0,他引:1
ISABELLE EMERY CLAUDE LECLERC KAPPRASEUTH SENGPHOMMACHANH DOMINIQUE ANGÈLE VUITTON & MARTINE LIANCE 《Parasite immunology》1998,20(2):81-91
Using an experimental model of hepatic Echinococcus multilocularis infection in C57BL/6J mice, intraperitoneal administration of 0.8 μg of recombinant IL-12 to mice with an established infection was shown to reduce the parasite burden as soon as two weeks after the end of treatment. At that time, in vitro Echinococcus multilocularis -induced spleen T cell proliferative responses as well as IFN-γ and IL-5 production were higher in IL-12 treated mice than in untreated mice. Administration of 0.8 μg of IL-12 at the time of infection was shown to be without effect on the parasite establishment. However, this treatment greatly inhibited the subsequent metacestode development. Indeed, ten weeks after infection, it induced a complete healing in 37.5% of mice. At that time, the development of metastases was inhibited in 68.75% of IL-12-treated mice. This reduction of parasite burden was mainly associated with a strong proliferation of spleen cells to E. multilocularis antigen and with a high IFN-γ production. Altogether, our results show that IL-12 is of crucial importance in inhibiting the larval growth after the metacestode establishment in the liver and suggest that this cytokine could be of potential value in the treatment of human alveolar echinococcosis . 相似文献
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HILDEGARD TANNER M.D. GERHARD HINDRICKS M.D. MARIUS VOLKMER M.D. † STEVE FURNISS M.D. ‡ VOLKER KÜHLKAMP M.D. § DOMINIQUE LACROIX M.D. Ph.D. ¶ CHRISTIAN DE CHILLOU M.D. Ph.D. # JESÚS ALMENDRAL M.D. Ph.D. DOMENICO CAPONI M.D. †† KARL-HEINZ KUCK M.D. † HANS KOTTKAMP M.D. 《Journal of cardiovascular electrophysiology》2010,21(1):47-53
Catheter Ablation of Ventricular Tachycardia. Introduction: Ventricular tachycardia (VT) late after myocardial infarction is an important contributor to morbidity and mortality. This prospective multicenter study assessed the efficacy and safety of electroanatomical mapping in combination with open-saline irrigated ablation technology for ablation of chronic recurrent mappable and unmappable VT in remote myocardial infarction.
Methods and Results: In 8 European institutions, 63 patients (89% males) were enrolled in the study. All patients had remote myocardial infarction and presented with a median number of 17 (range 1–380) VTs in the preceding 6 months. Incessant VT was present in 14 patients (22%). Left ventricular ejection fraction measured 30 ± 13%. A mean of 3 VTs were targeted per patient and 22% of all patients had only unmappable VT. The mean follow-up period was 12 ± 3 months. A total of 164 VTs were targeted during catheter ablation. Ablation was acutely successful in 51 patients (81%). One patient (1.5%) experienced a major complication with degeneration of VT into ventricular fibrillation necessitating cardiopulmonary resuscitation maneuvers. However, no death occurred acutely or within the first 30 days after catheter ablation. During the follow-up, 19 of the initially successful ablated patients (37%) and 31 of all ablated patients (49%) developed some type of VT recurrence.
Conclusions: The results of this multicenter study demonstrate the high acute success rate and a low complication rate of irrigated tip catheter ablation of all clinical relevant VTs in remote myocardial infarction. However, during the follow-up a relevant number of recurrences occurred. (J Cardiovasc Electrophysiol, Vol. 21, pp. 47–53, January 2010) 相似文献
Methods and Results: In 8 European institutions, 63 patients (89% males) were enrolled in the study. All patients had remote myocardial infarction and presented with a median number of 17 (range 1–380) VTs in the preceding 6 months. Incessant VT was present in 14 patients (22%). Left ventricular ejection fraction measured 30 ± 13%. A mean of 3 VTs were targeted per patient and 22% of all patients had only unmappable VT. The mean follow-up period was 12 ± 3 months. A total of 164 VTs were targeted during catheter ablation. Ablation was acutely successful in 51 patients (81%). One patient (1.5%) experienced a major complication with degeneration of VT into ventricular fibrillation necessitating cardiopulmonary resuscitation maneuvers. However, no death occurred acutely or within the first 30 days after catheter ablation. During the follow-up, 19 of the initially successful ablated patients (37%) and 31 of all ablated patients (49%) developed some type of VT recurrence.
Conclusions: The results of this multicenter study demonstrate the high acute success rate and a low complication rate of irrigated tip catheter ablation of all clinical relevant VTs in remote myocardial infarction. However, during the follow-up a relevant number of recurrences occurred. (J Cardiovasc Electrophysiol, Vol. 21, pp. 47–53, January 2010) 相似文献
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Endless-Loop Tachycardias: Description and First Clinical Results of a New Fully Automatic Protection Algorithm 总被引:1,自引:0,他引:1
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A. TRIPODI Q. M. ANSTEE K. K. SOGAARD M. PRIMIGNANI D. C. VALLA 《Journal of thrombosis and haemostasis》2011,9(9):1713-1723
Summary. Decreased levels of most coagulation factors and thrombocytopenia are the main haemostatic abnormalities of cirrhosis. As a consequence, this condition was, until recently, considered as the prototype acquired coagulopathy responsible for bleeding. However, recent evidence suggests that it should, rather, be regarded as a condition associated with normal or even increased thrombin generation. The bleeding events that occur in these patients should, therefore, be explained by the superimposed conditions that frequently occur in this setting. Due to elevated levels of factor VIII (procoagulant driver) in combination with decreased protein C (anticoagulant driver), which are typically found in patients with cirrhosis, a procoagulant imbalance, defined as a partial resistance to the in vitro anticoagulant action of thrombomodulin, can be demonstrated. Whether this in vitro hypercoagulability is truly representative of what occurs in vivo remains to be established. However, the hypothesis that it may have clinical consequences is attractive and deserves attention. The possible consequences that we discuss herein include whether (i) cirrhosis is a condition associated with increased risk of venous thromboembolism or portal vein thrombosis; (ii) the hypercoagulability associated with cirrhosis has any other role outside coagulation (i.e. progression of liver fibrosis); and (iii) anticoagulation should be used in cirrhosis. Although apparently provocative, considering anticoagulation as a therapeutic option in patients with cirrhosis is now supported by a rationale of increasing strength. There may be subgroups of patients who benefit from anticoagulation to treat or prevent thrombosis and to slow hepatic fibrosis. Clinical studies are warranted to explore these therapeutic options. 相似文献
10.
The posterior sacral foramina: an anatomical study 总被引:1,自引:0,他引:1
DOMINIQUE LIGUORO DIDIER VIEJO-FUERTES DOMINIQUE MIDY JEAN GUERIN 《Journal of anatomy》1999,195(2):301-304
The vascular and nervous structures and their relations with the spinal nerve roots were examined in the 2nd, 3rd and 4th posterior sacral foramina in relation to percutaneous needle insertion for neuromodulation. A foraminal branch provided by the lateral sacral artery to each foramen entered the inferior lateral quadrant of each foramen, adjacent to the nerve root medially. Facing the posterior sacral aperture and around the sacral nerves, there was no venous plexus. A venous plexus was sometimes present near the median line, and always around the proximal part of the spinal ganglion. The sacral nerve roots, especially the 3rd, had a long extradural course in the foramen, presenting a potential risk of nerve lesions during procedures involving needle insertion. 相似文献