全文获取类型
收费全文 | 812篇 |
免费 | 57篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 76篇 |
妇产科学 | 12篇 |
基础医学 | 118篇 |
口腔科学 | 35篇 |
临床医学 | 56篇 |
内科学 | 134篇 |
皮肤病学 | 2篇 |
神经病学 | 77篇 |
特种医学 | 29篇 |
外科学 | 88篇 |
综合类 | 11篇 |
预防医学 | 50篇 |
眼科学 | 8篇 |
药学 | 107篇 |
中国医学 | 4篇 |
肿瘤学 | 62篇 |
出版年
2021年 | 15篇 |
2019年 | 5篇 |
2018年 | 12篇 |
2017年 | 9篇 |
2015年 | 9篇 |
2014年 | 23篇 |
2013年 | 30篇 |
2012年 | 26篇 |
2011年 | 30篇 |
2010年 | 21篇 |
2009年 | 23篇 |
2008年 | 31篇 |
2007年 | 34篇 |
2006年 | 30篇 |
2005年 | 36篇 |
2004年 | 43篇 |
2003年 | 49篇 |
2002年 | 33篇 |
2001年 | 24篇 |
2000年 | 25篇 |
1999年 | 17篇 |
1998年 | 15篇 |
1997年 | 10篇 |
1996年 | 10篇 |
1995年 | 13篇 |
1994年 | 14篇 |
1993年 | 6篇 |
1992年 | 12篇 |
1991年 | 8篇 |
1990年 | 14篇 |
1989年 | 14篇 |
1988年 | 15篇 |
1987年 | 12篇 |
1986年 | 20篇 |
1985年 | 10篇 |
1984年 | 15篇 |
1983年 | 13篇 |
1982年 | 8篇 |
1981年 | 11篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1974年 | 11篇 |
1973年 | 6篇 |
1972年 | 7篇 |
1971年 | 10篇 |
1970年 | 9篇 |
1967年 | 10篇 |
1939年 | 5篇 |
排序方式: 共有872条查询结果,搜索用时 171 毫秒
1.
Combined percutaneous antegrade and cystoscopic retrograde approach in the treatment of distal ureteric fistulae 总被引:1,自引:1,他引:0
Thierry de Baere Alain Roche Christine Lagrange Alban Denys Bernard Court Joël Isapoff Paris Pappas 《Cardiovascular and interventional radiology》1995,18(6):349-352
Purpose To determine the efficacy of a cystoscopic approach, as definitive treatment of ureteral fistulae, after failure of antegrade ureteral stent insertion.Methods Of 43 ureter fistulae encountered over 4 years, 10 postoperative and/or postradiotherapy fistulae could not be stented via an antegrade approach alone. A cystoscopic approach was used, with the antegrade approach available as back-up, if necessary.Results In two patients the ureteral orifice could not be visualized cystoscopically, thus precluding the retrograde approach. In the eight remaining patients, the retrograde approach alone never allowed successful stenting. In six patients, combined antegrade and retrograde approaches permitted stent insertions. In three of those six patients, a complex catheterization procedure was necessary. In two patients the combined approach failed altogether. Therefore, 6 of 10 patients underwent a successful stenting procedure with the combined approach; all ultimately closed the fistula.Conclusion Antegrade stent insertion remains the treatment of choice for ureteral leaks. If the antegrade approach fails, the retrograde approach alone is not likely to be successful. Instead, a combination of both approaches often does succeed. 相似文献
2.
3.
W. E. Court 《Medical history》1983,27(3):332-333
4.
Niels Fisker Court Pedersen Marianne Lange Nga Thien Tich Nguyen Kim Thien Tich Nguyen J?rgen Georgsen Peer Brehm Christensen 《Journal of clinical virology》2004,31(1):46-52
BACKGROUND: Denmark has a low incidence of acute hepatitis B (HBV) infections but the impact of an increasing number of immigrants with chronic HBV infection on HBV transmission is unknown. OBJECTIVES: To characterise individuals with chronic and acute HBV infection in a defined region and to examine the importance of different risk groups for the current HBV transmission. METHODS: During 2000-2001 all consecutive HBV infected individuals routinely diagnosed through the regional HBV serology laboratory in the County of Funen were classified according to ethnicity, presumed route of transmission and stage of infection based on clinical data mainly supplied by the requesting physician. HBV DNA was sequenced and subjected to phylogenetic analysis. RESULTS: Of 309 identified cases, 91 (29%) were classified as acute infection. HBV DNA sequencing was possible in 54 (59%) of these cases. Phylogenetic analysis showed that HBV isolated from injecting drug users (IDUs) was identical or closely related. Among acute cases acquired in Denmark 89% (74/83) were seen in IDUs (65) or in individuals presumably exposed to IDUs (nine) and phylogenetic analysis corroborated the assumption of IDU related transmission in every case with available sequence data. Among 83 ethnic Danes who acquired their HBV infection in Denmark, no new cases of transmission from immigrants were detected. CONCLUSION: Injecting drug use was the single most important factor for hepatitis B transmission in Denmark. The current Danish vaccination strategy is unable to protect IDUs from HBV infection and IDUs pose a greater risk of HBV transmission to the general population than immigrants. 相似文献
5.
Comparison of a modified microagglutination technique for HBsAg with the standard technique and a new RIA system.
下载免费PDF全文
![点击此处可从《Journal of clinical pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
E M Supran P S Gardner I Cayzer G Court S Chalmers 《Journal of clinical pathology》1981,34(12):1396-1399
A further modification of the standard RPHA technique (Hepatest, Wellcome Reagents) for the detection of HBsAg is described. This modification does not require a centrifugation step which is required by the other modifications that have been described previously and consequently takes a little longer to perform. It does, however, retain the advantages of increased sensitivity and decreased costs which are also features of the other modifications. A series of 939 routine clinical specimens were used to evaluate the method described and to evaluate a new RIA kit for the detection of HBsAg (Hepatube, Wellcome Reagents). Of 53 specimens found to be positive for HBsAg by RIA, 50 (94% were detected by the modified Hepatest RPHA as opposed to 47 (89%) by the standard technique. 相似文献
6.
7.
Masquelier B Bhaskaran K Pillay D Gifford R Balestre E Jørgensen LB Pedersen C van der Hoek L Prins M Balotta C Longo B Kücherer C Poggensee G Ortiz M de Mendoza C Gill J Fleury H Porter K;CASCADE Collaboration 《Journal of acquired immune deficiency syndromes (1999)》2005,40(5):505-511
OBJECTIVES: To examine factors influencing the rate of transmitted drug resistance (TDR) among seroconverters, with particular emphasis on 3 widely used genotypic drug resistance algorithms. METHODS: The study used data from CASCADE (Concerted Action on Seroconversion to AIDS and Death in Europe), a collaboration of seroconverter cohorts in Europe and Canada. Genotypic resistance data were derived within 18 months of the last seronegative test or date of laboratory evidence of acute infection and before the initiation of antiretroviral therapy. The Stanford algorithm was used to analyze each individual's nucleotide sequence. A multivariate logistic model was used to assess independent relationships between the presence of TDR and exposure category, sex, age at seroconversion, and year of seroconversion. The paper also describes 3 alternative definitions of resistance: the Stanford algorithm, the key resistance mutations defined by the International AIDS Society, and the Agence Nationale de Recherches sur le Sida (ANRS) algorithm. RESULTS: Forty-five of 438 patients (10.3%) seroconverting between 1987 and 2003 were infected with a drug-resistant HIV-1 variant. Forty patients (9.1%) showed resistance mutations to only 1 class of antiretroviral drugs, 2 (0.5%) to 2 classes, and 3 (0.7%) to 3 classes of antiretroviral therapy. It was suggested that individuals seroconverting later in calendar time were more likely to have TDR (relative risk 3.89 and 95% CI: 0.84 to 18.02, and relative risk 4.69 and 95% CI: 1.03 to 21.31, for 1996-1999 and 2000-2003, respectively, compared with pre-1996; P trend = 0.08). This trend was apparent regardless of the definition of TDR used. The total estimated proportion of individuals with TDR varied between 10.3% and 15.5% according to which definition was used. CONCLUSIONS: Evidence was found for the rise of TDR over time. A specific definition of what constitutes TDR rather than a simple list of mutations is needed. 相似文献
8.
Erythrocyte membrane fluidity was determined in a group of type 1 diabetics in varying metabolic control. No difference in membrane fluidity, as measured by fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene, was found between cells from diabetic subjects. In addition, no difference was detected in membrane phospholipid and cholesterol content or the ratio of cholesterol to phospholipid in the diabetic subjects when compared to controls. The present study suggests that changes in erythrocyte membrane fluidity do not play a major role in the alterations of the physical properties of blood seen in type 1 diabetes mellitus. 相似文献
9.
Vaughan JR; Farrer MJ; Wszolek ZK; Gasser T; Durr A; Agid Y; Bonifati V; DeMichele G; Volpe G; Lincoln S; Breteler M; Meco G; Brice A; Marsden CD; Hardy J; Wood NW 《Human molecular genetics》1998,7(4):751-753
A mutation in exon 4 of the human alpha-synuclein gene was reported
recently in four families with autosomal dominant Parkinson's disease (PD).
In order to examine whether mutations in this exon or elsewhere in the gene
are common in familial PD, all seven exons of the alpha- synuclein gene
were amplified by PCR from index cases of 30 European and American
Caucasian kindreds affected with autosomal dominant PD. Each product was
sequenced directly and examined for mutations in the open reading frame. No
mutations were found in any of the samples examined. We conclude that the
A53T change described in the alpha- synuclein gene is a rare cause of PD or
may even be a rare variant. Mutations in the regulatory or intronic regions
of the gene were not excluded by this study.
相似文献
10.
June A Peters Susan T Vadaparampil Joan Kramer Richard P Moser Lori Jo Peterson Court Jennifer Loud Mark H Greene 《Genetics in medicine》2006,8(12):760-770
PURPOSE: This study is part of an ongoing National Cancer Institute multidisciplinary, etiologically-focused, cross-sectional study of Familial Testicular Cancer (FTC). The current report targets interest in clinical genetic testing for susceptibility to FTC. METHODS: Demographics, knowledge, health beliefs, and psychological and social factors were evaluated as covariates related to interest in genetic testing. RESULTS: The majority (66%) of 229 participants (64 affected men, 66 unaffected men, and 99 women) from 47 multiple-case FTC families expressed interest in having a genetic test within 6 months, should such a test become available. Interest was similar among the three subgroups mentioned above. Worries about insurance discrimination based on genetic test results were associated with a significantly lower interest in testing. Alternatively, participants were more likely to be interested in genetic testing if they were younger and had higher levels of family support, a physician's recommendation supporting testing, cancer distress, and a need for information to inform the health care of their children. CONCLUSIONS: This study reveals social and relationship factors that FTC survivors and their relatives considered important when contemplating the use of new genetic technologies. This is the first study describing hypothetical interest in genetic testing for familial testicular cancer. 相似文献