全文获取类型
收费全文 | 12252篇 |
免费 | 686篇 |
国内免费 | 219篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 822篇 |
妇产科学 | 863篇 |
基础医学 | 936篇 |
口腔科学 | 173篇 |
临床医学 | 1558篇 |
内科学 | 3100篇 |
皮肤病学 | 201篇 |
神经病学 | 783篇 |
特种医学 | 316篇 |
外国民族医学 | 5篇 |
外科学 | 998篇 |
综合类 | 868篇 |
一般理论 | 2篇 |
预防医学 | 835篇 |
眼科学 | 193篇 |
药学 | 733篇 |
中国医学 | 140篇 |
肿瘤学 | 587篇 |
出版年
2023年 | 73篇 |
2022年 | 107篇 |
2021年 | 165篇 |
2020年 | 115篇 |
2019年 | 87篇 |
2018年 | 191篇 |
2017年 | 178篇 |
2016年 | 183篇 |
2015年 | 190篇 |
2014年 | 164篇 |
2013年 | 409篇 |
2012年 | 718篇 |
2011年 | 988篇 |
2010年 | 350篇 |
2009年 | 330篇 |
2008年 | 695篇 |
2007年 | 770篇 |
2006年 | 663篇 |
2005年 | 732篇 |
2004年 | 924篇 |
2003年 | 933篇 |
2002年 | 742篇 |
2001年 | 578篇 |
2000年 | 257篇 |
1999年 | 306篇 |
1998年 | 285篇 |
1997年 | 210篇 |
1996年 | 163篇 |
1995年 | 132篇 |
1994年 | 118篇 |
1993年 | 116篇 |
1992年 | 138篇 |
1991年 | 137篇 |
1990年 | 96篇 |
1989年 | 91篇 |
1988年 | 68篇 |
1987年 | 70篇 |
1986年 | 55篇 |
1985年 | 58篇 |
1984年 | 52篇 |
1983年 | 43篇 |
1982年 | 35篇 |
1981年 | 40篇 |
1980年 | 29篇 |
1979年 | 44篇 |
1978年 | 33篇 |
1977年 | 31篇 |
1976年 | 21篇 |
1975年 | 33篇 |
1973年 | 33篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
L. Misery E. Weisshaar E. Brenaut A.W.M. Evers F. Huet S. Ständer A. Reich E. Berardesca E. Serra-Baldrich J. Wallengren D. Linder J.W. Fluhr J.C. Szepietowski H. Maibach for the Special Interest Group on sensitive skin of the International Forum for the Study of Itch 《Journal of the European Academy of Dermatology and Venereology》2020,34(2):222-229
The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations of the skin nervous system. Skin barrier abnormalities are frequently associated, but there is no cause and direct relationship. Further studies are needed to better understand the pathophysiology of sensitive skin – as well as the inducing factors. Avoidance of possible triggering factors and the use of well-tolerated cosmetics, especially those containing inhibitors of unpleasant sensations, might be suggested for patients with sensitive skin. The role of psychosocial factors, such as stress or negative expectations, might be relevant for subgroups of patients. To date, there is no clinical trial supporting the use of topical or systemic drugs in sensitive skin. The published data are not sufficient to reach a consensus on sensitive skin management. In general, patients with sensitive skin require a personalized approach, taking into account various biomedical, neural and psychosocial factors affecting sensitive skin. 相似文献
4.
目的:制备高表达GM-CSF的淋巴瘤细胞系,观察淋巴瘤细胞转染GM-CSF基因后生物学特性的改变。方法:将小鼠GF-CSF真核表达质粒用电穿孔法导入小鼠淋巴瘤细胞系RMA,有限稀释法制备单个细胞克隆,经RT-PCR,骨髓祖细胞增殖实验和集落形成实验筛选相对高表达GM-CSF的RMA克隆,并观察其生物学特性的改变。结果:获得了高表达GM-CS的RMA细胞系,其同基因动物体内致瘤性降低。结论:淋巴瘤细胞系RMA转染GM-CSF基因后致瘤性降低。 相似文献
5.
6.
膨润土对药用混悬液助悬性能的考察 总被引:9,自引:1,他引:8
本文报道了无机胶体膨润土(Bentonite)作为助悬剂在炉甘石洗剂中的应用,并与有机助悬剂及另一种无机胶体XVT—M进行比较,显示了其优异的助悬性能。 相似文献
7.
作者用自制的[~(125)I]标记激素,参考国外经验,建立了人血清胰岛素抗体、猪胰岛素原抗体和胰多肽抗体等三种放射免疫检测法,并对方法的主要实验条件进行了优选,对方法的质量控制参数作了验证。结果发现:在使用国产胰岛素的糖尿病人血清中,三种抗体的检出率分别为90.8%、48.3%和36.5%;抗体特异性结合值分别为21.2±17.4%、41.8±27.4%和25.6±28.4;而正常人和糖尿病人未用胰岛素者全部为阴性,显示国产胰岛素具有明显的免疫原性。 相似文献
8.
9.
M. Laurin Council Jennifer M. Gardner Cynthia Helms Ying Liu Lynn A. Cornelius Anne M. Bowcock 《Experimental dermatology》2009,18(5):485-487
Abstract: The risks of developing malignant melanoma (MM) include ultraviolet irradiation and genetic factors. To examine the contribution of rare and common variation within known MM genes in sporadic US MM patients, coding regions of known MM susceptibility genes [cyclin-dependent kinase inhibitor 2A ( CDKN2A ), cyclin-dependent kinase 4, melanocortin 1 receptor ( MC1R ) and tyrosinase ( TYR )] were resequenced in 109–135 MM cases. The significance of variants was examined by comparing their frequencies in 390 cancer-free controls. Potential deleterious mutations in CDKN2A were found in two patients and two others had variants of unknown significance. Cases were more likely than controls to harbour the MC1R 'R' variants known or predicted to alter its function ( P = 0.002), particularly the R160W variant ( P = 0.0035). The associated TYR R402Q variant (rs1126809*A) was found in 29% of cases, similar to what has been described previously. One MM patient with a family history of MM, who had developed other skin cancers, was homozygous for a novel TYR variant (P406L) of unknown significance. Hence, rare variants in TYR may be important risk factors for skin cancer. 相似文献
10.