全文获取类型
收费全文 | 2354篇 |
免费 | 183篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 40篇 |
妇产科学 | 16篇 |
基础医学 | 404篇 |
口腔科学 | 203篇 |
临床医学 | 239篇 |
内科学 | 456篇 |
皮肤病学 | 43篇 |
神经病学 | 122篇 |
特种医学 | 188篇 |
外科学 | 303篇 |
综合类 | 105篇 |
一般理论 | 1篇 |
预防医学 | 172篇 |
眼科学 | 24篇 |
药学 | 117篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 101篇 |
出版年
2021年 | 30篇 |
2018年 | 36篇 |
2016年 | 27篇 |
2015年 | 32篇 |
2014年 | 69篇 |
2013年 | 76篇 |
2012年 | 83篇 |
2011年 | 85篇 |
2010年 | 59篇 |
2009年 | 57篇 |
2008年 | 62篇 |
2007年 | 57篇 |
2006年 | 108篇 |
2005年 | 69篇 |
2004年 | 52篇 |
2003年 | 50篇 |
2002年 | 59篇 |
2001年 | 49篇 |
2000年 | 41篇 |
1999年 | 62篇 |
1998年 | 44篇 |
1997年 | 67篇 |
1996年 | 66篇 |
1995年 | 53篇 |
1994年 | 42篇 |
1993年 | 46篇 |
1992年 | 59篇 |
1991年 | 54篇 |
1990年 | 53篇 |
1989年 | 47篇 |
1988年 | 48篇 |
1987年 | 46篇 |
1986年 | 42篇 |
1985年 | 39篇 |
1984年 | 40篇 |
1983年 | 42篇 |
1982年 | 36篇 |
1981年 | 30篇 |
1980年 | 21篇 |
1979年 | 26篇 |
1978年 | 22篇 |
1976年 | 40篇 |
1975年 | 32篇 |
1974年 | 42篇 |
1973年 | 21篇 |
1971年 | 24篇 |
1970年 | 19篇 |
1969年 | 20篇 |
1967年 | 18篇 |
1966年 | 28篇 |
排序方式: 共有2544条查询结果,搜索用时 15 毫秒
1.
Leah H. Cobb Emily M. McCabe Lauren B. Priddy 《Journal of orthopaedic research》2020,38(10):2091-2103
Osteomyelitis, or the infection of the bone, presents a major complication in orthopedics and may lead to prolonged hospital visits, implant failure, and in more extreme cases, amputation of affected limbs. Typical treatment for this disease involves surgical debridement followed by long-term, systemic antibiotic administration, which contributes to the development of antibiotic-resistant bacteria and has limited ability to eradicate challenging biofilm-forming pathogens including Staphylococcus aureus—the most common cause of osteomyelitis. Local delivery of high doses of antibiotics via traditional bone cement can reduce systemic side effects of an antibiotic. Nonetheless, growing concerns over burst release (then subtherapeutic dose) of antibiotics, along with microbial colonization of the nondegradable cement biomaterial, further exacerbate antibiotic resistance and highlight the need to engineer alternative antimicrobial therapeutics and local delivery vehicles with increased efficacy against, in particular, biofilm-forming, antibiotic-resistant bacteria. Furthermore, limited guidance exists regarding both standardized formulation protocols and validated assays to predict efficacy of a therapeutic against multiple strains of bacteria. Ideally, antimicrobial strategies would be highly specific while exhibiting a broad spectrum of bactericidal activity. With a focus on S. aureus infection, this review addresses the efficacy of novel therapeutics and local delivery vehicles, as alternatives to the traditional antibiotic regimens. The aim of this review is to discuss these components with regards to long bone osteomyelitis and to encourage positive directions for future research efforts. 相似文献
2.
3.
4.
De Leo V; Morgante G; Lanzetta D; D'Antona D; Bertieri RS 《Human reproduction (Oxford, England)》1997,12(2):357-360
We report the results of administration of danazol after suspension of
gonadotrophin-releasing hormone analogue (GnRHa) therapy for uterine
myomas. A total of 21 women with uterine myomas was treated with 100 mg
danazol for 6 months after GnRHa therapy. Uterine volume and endocrine
status were monitored monthly by ultrasound and assay of plasma
gonadotrophins, oestradiol and progesterone. The results show a rebound of
uterine volume about 30% less than in controls at the end of danazol
therapy. Menstrual cyclicity returned after 65 +/- 3 days in 16 subjects
and five patients remained amenorrhoeic. Hormone assays confirmed renewed
ovarian function in the women whose menstrual periods returned. Bone
mineral content was substantially reduced during GnRHa treatment but
improved significantly during danazol therapy even in the women who
remained amenorrhoeic. These results show the utility of danazol in
prolonging the therapeutic effects of GnRHa. The mechanism by which danazol
inhibits rebound of uterine volume may be due to its antiprogesterone
effects on uterine myomas.
相似文献
5.
6.
7.
Prior studies have shown that pneumothorax is one of the more difficult entities to diagnose with digitized radiography. This study was designed to test whether increasing resolution from 1.25 to 2.5 line pairs per millimeter (lp/mm) and image processing (edge enhancement from unsharp masking) would increase accuracy and confidence in the diagnosis of pneumothorax, as well as normal cases and other forms of lung disease. Conventional radiographs were digitized with use of a laser reader and then reformatted as film hard copy. Eleven observers read 35 cases reformatted in three different ways (1.25 lp/mm, 2.5 lp/mm, 1.25 lp/mm unsharp mask). The images with finer resolution (2.5 lp/mm) and unsharp mask images were superior to those with coarser resolution (1.25 lp/mm) for the diagnosis of pneumothorax. There was no difference in diagnostic accuracy for normal patients. For abnormalities other than pneumothorax, the unsharp mask images were significantly worse. Confidence in the diagnosis of pneumothorax and other abnormalities was highest with the finest resolution (2.5 lp/mm). 相似文献
8.
The authors report the clinical and laboratory findings of a patient who had severe immune hemolytic anemia due to hydrochlorothiazide (HCTZ). In this case, the HCTZ antibody reacted not only with other thiazide and thiazide-like drugs, but also with a chemically unrelated diuretic, ethacrynic acid. These results indicate that HCTZ antibody activity is not restricted solely to the thiazides and imply that therapy with any of the reactive drugs would be contraindicated for this patient. The serologic screening for drug reactivity may be useful for selecting alternative therapy for patients with drug-induced immune hemolytic anemia. 相似文献
9.
A controlled trial of scheduled replacement of central venous and pulmonary-artery catheters. 总被引:12,自引:0,他引:12
D K Cobb K P High R G Sawyer C A Sable R B Adams D A Lindley T L Pruett K J Schwenzer B M Farr 《The New England journal of medicine》1992,327(15):1062-1068
BACKGROUND. The incidence of infection increases with the prolonged use of central vascular catheters, but it is unclear whether changing catheters every three days, as some recommend, will reduce the rate of infection, It is also unclear whether it is safer to change a catheter over a guide wire or insert it at a new site. METHODS. We conducted a controlled trial in adult patients in intensive care units who required central venous or pulmonary-artery catheters for more than three days. Patients were assigned randomly to undergo one of four methods of catheter exchange: replacement every three days either by insertion at a new site (group 1) or by exchange over a guide wire (group 2), or replacement when clinically indicated either by insertion at a new site (group 3) or by exchange over a guide wire (group 4). RESULTS. Of the 160 patients, 5 percent had catheter-related bloodstream infections, 16 percent had catheters that became colonized, and 9 percent had major mechanical complications. The incidence rates (per 1000 days of catheter use) of bloodstream infection were 3 in group 1, 6 in group 2, 2 in group 3, and 3 in group 4; the incidence rates of mechanical complications were 14, 4, 8, and 3, respectively. Patients randomly assigned to guide-wire-assisted exchange were more likely to have bloodstream infection after the first three days of catheterization (6 percent vs. 0, P = 0.06). Insertions at new sites were associated with more mechanical complications (5 percent vs. 1 percent, P = 0.005). CONCLUSIONS. Routine replacement of central vascular catheters every three days does not prevent infection. Exchanging catheters with the use of a guide wire increases the risk of bloodstream infection, but replacement involving insertion of catheters at new sites increases the risk of mechanical complications. 相似文献
10.