全文获取类型
收费全文 | 45263篇 |
免费 | 3388篇 |
国内免费 | 282篇 |
专业分类
耳鼻咽喉 | 636篇 |
儿科学 | 1120篇 |
妇产科学 | 1273篇 |
基础医学 | 5631篇 |
口腔科学 | 1202篇 |
临床医学 | 4647篇 |
内科学 | 10392篇 |
皮肤病学 | 807篇 |
神经病学 | 4244篇 |
特种医学 | 1679篇 |
外国民族医学 | 2篇 |
外科学 | 6831篇 |
综合类 | 400篇 |
一般理论 | 17篇 |
预防医学 | 3051篇 |
眼科学 | 692篇 |
药学 | 2895篇 |
3篇 | |
中国医学 | 107篇 |
肿瘤学 | 3304篇 |
出版年
2023年 | 261篇 |
2022年 | 526篇 |
2021年 | 966篇 |
2020年 | 638篇 |
2019年 | 809篇 |
2018年 | 1043篇 |
2017年 | 819篇 |
2016年 | 936篇 |
2015年 | 1068篇 |
2014年 | 1443篇 |
2013年 | 1856篇 |
2012年 | 2810篇 |
2011年 | 2935篇 |
2010年 | 1637篇 |
2009年 | 1520篇 |
2008年 | 2557篇 |
2007年 | 2564篇 |
2006年 | 2462篇 |
2005年 | 2302篇 |
2004年 | 2377篇 |
2003年 | 2176篇 |
2002年 | 1902篇 |
2001年 | 917篇 |
2000年 | 816篇 |
1999年 | 835篇 |
1998年 | 459篇 |
1997年 | 384篇 |
1996年 | 372篇 |
1995年 | 333篇 |
1994年 | 270篇 |
1993年 | 284篇 |
1992年 | 615篇 |
1991年 | 584篇 |
1990年 | 509篇 |
1989年 | 583篇 |
1988年 | 526篇 |
1987年 | 529篇 |
1986年 | 498篇 |
1985年 | 507篇 |
1984年 | 370篇 |
1983年 | 330篇 |
1982年 | 230篇 |
1981年 | 215篇 |
1979年 | 276篇 |
1978年 | 210篇 |
1977年 | 182篇 |
1976年 | 192篇 |
1974年 | 204篇 |
1973年 | 209篇 |
1971年 | 171篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Julie Despres Yasmina Ramdani Marine di Giovanni Magalie Bnard Abderrakib Zahid Mait Montero‐Hadjadje Florent Yvergnaux Thibaut Saguet Azeddine Driouich Marie‐Laure Follet‐Gueye 《Experimental dermatology》2019,28(8):922-932
It is well recognized that the world population is ageing rapidly. Therefore, it is important to understand ageing processes at the cellular and molecular levels to predict the onset of age‐related diseases and prevent them. Recent research has focused on the identification of ageing biomarkers, including those associated with the properties of the Golgi apparatus. In this context, Golgi‐mediated glycosylation of proteins has been well characterized. Additionally, other studies show that the secretion of many compounds, including pro‐inflammatory cytokines and extracellular matrix–degrading enzymes, is modified during ageing, resulting in physical and functional skin degradation. Since the Golgi apparatus is a central organelle of the secretory pathway, we investigated its structural organization in senescent primary human dermal fibroblasts using confocal and electron microscopy. In addition, we monitored the expression of Golgi‐related genes in the same cells. Our data showed a marked alteration in the Golgi morphology during replicative senescence. In contrast to its small and compact structure in non‐senescent cells, the Golgi apparatus exhibited a large and expanded morphology in senescent fibroblasts. Our data also demonstrated that the expression of many genes related to Golgi structural integrity and function was significantly modified in senescent cells, suggesting a relationship between Golgi apparatus function and ageing. 相似文献
2.
3.
4.
5.
6.
Anna Maria Colangelo Giovanni Cirillo Lilia Alberghina Michele Papa Hans V.Westerhoff 《中国神经再生研究》2019,(2)
The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology. 相似文献
7.
8.
Archie L. Overmann DesRaj M. Clark Panagiotis Tsagkozis Rikard Wedin Jonathan A. Forsberg 《Journal of orthopaedic research》2020,38(10):2149-2156
Treatment decisions in patients with metastatic bone disease rely on accurate survival estimation. We developed the original PATHFx models using expensive, proprietary software and now seek to provide a more cost-effective solution. Using open-source machine learning software to create PATHFx version 2.0, we asked whether PATHFx 2.0 could be created using open-source methods and externally validated in two unique patient populations. The training set of a well-characterized, database records of 189 patients and the bnlearn package within R Version 3.5.1 (R Foundation for Statistical Computing), was used to establish a series of Bayesian belief network models designed to predict survival at 1, 3, 6, 12, 18, and 24 months. Each was externally validated in both a Scandinavian (n = 815 patients) and a Japanese (n = 261 patients) data set. Brier scores and receiver operating characteristic curves to assessed discriminatory ability. Decision curve analysis (DCA) evaluated whether models should be used clinically. DCA showed that the model should be used clinically at all time points in the Scandinavian data set. For the 1-month time point, DCA of the Japanese data set suggested to expect better outcomes assuming all patients will survive greater than 1 month. Brier scores for each curve demonstrate that the models are accurate at each time point. Statement of Clinical Significance: we successfully transitioned to PATHFx 2.0 using open-source software and externally validated it in two unique patient populations, which can be used as a cost-effective option to guide surgical decisions in patients with metastatic bone disease. 相似文献
9.