全文获取类型
收费全文 | 47585篇 |
免费 | 3171篇 |
国内免费 | 391篇 |
专业分类
耳鼻咽喉 | 781篇 |
儿科学 | 771篇 |
妇产科学 | 1009篇 |
基础医学 | 6719篇 |
口腔科学 | 1195篇 |
临床医学 | 4182篇 |
内科学 | 9375篇 |
皮肤病学 | 1176篇 |
神经病学 | 3319篇 |
特种医学 | 2654篇 |
外科学 | 7031篇 |
综合类 | 1091篇 |
现状与发展 | 1篇 |
一般理论 | 23篇 |
预防医学 | 2201篇 |
眼科学 | 1362篇 |
药学 | 3885篇 |
1篇 | |
中国医学 | 430篇 |
肿瘤学 | 3941篇 |
出版年
2023年 | 359篇 |
2022年 | 803篇 |
2021年 | 1472篇 |
2020年 | 827篇 |
2019年 | 1203篇 |
2018年 | 1404篇 |
2017年 | 1091篇 |
2016年 | 1282篇 |
2015年 | 1800篇 |
2014年 | 2224篇 |
2013年 | 2452篇 |
2012年 | 3747篇 |
2011年 | 3678篇 |
2010年 | 2182篇 |
2009年 | 1980篇 |
2008年 | 2746篇 |
2007年 | 2675篇 |
2006年 | 2544篇 |
2005年 | 2416篇 |
2004年 | 2058篇 |
2003年 | 1758篇 |
2002年 | 1502篇 |
2001年 | 1283篇 |
2000年 | 1246篇 |
1999年 | 990篇 |
1998年 | 343篇 |
1997年 | 310篇 |
1996年 | 255篇 |
1995年 | 241篇 |
1994年 | 205篇 |
1993年 | 174篇 |
1992年 | 407篇 |
1991年 | 361篇 |
1990年 | 327篇 |
1989年 | 310篇 |
1988年 | 272篇 |
1987年 | 252篇 |
1986年 | 209篇 |
1985年 | 174篇 |
1984年 | 157篇 |
1983年 | 120篇 |
1982年 | 93篇 |
1980年 | 91篇 |
1979年 | 128篇 |
1978年 | 89篇 |
1977年 | 89篇 |
1975年 | 78篇 |
1974年 | 77篇 |
1972年 | 82篇 |
1971年 | 76篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Andy KH Lim 《World journal of gastroenterology : WJG》2020,26(10):1020-1028
Rhabdomyolysis is a syndrome of skeletal muscle injury with release of cellular constituents such as potassium,phosphate,urate and intracellular proteins such as myoglobin into the circulation,which may cause complications including acute kidney injury,electrolyte disturbance and cardiac instability.Abnormal liver function tests are frequently observed in cases of severe rhabdomyolysis.Typically,there is an increase in serum aminotransferases,namely aspartate aminotransferase and alanine aminotransferase.This raises the question of liver injury and often triggers a pathway of investigation which may lead to a liver biopsy.However,muscle can also be a source of the increased aminotransferase activity.This review discusses the dilemma of finding abnormal liver function tests in the setting of muscle injury and the potential implications of such an association.It delves into some of the clinical and experimental evidence for correlating muscle injury to raised aminotransferases,and discusses pathophysiological mechanisms such as oxidative stress which may cause actual liver injury.Serum aminotransferases lack tissue specificity to allow clinicians to distinguish primary liver injury from muscle injury.This review also explores potential approaches to improve the accuracy of our diagnostic tools,so that excessive or unnecessary liver investigations can be avoided. 相似文献
2.
3.
Devagi Kanakaraju Nurfatyha Rusydah bt Mohamad Shahdad Ying-Chin Lim Andrea Pace 《Sustainable Chemistry and Pharmacy》2019
The use of multifunctional materials for water remediation is a modern approach where adsorption phenomena and heterogeneous photocatalysis can be applied for the removal of pollutants. Since the ideal remediation system should be able to remove both organic and inorganic pollutants, a crucial aspect to consider is the knowledge of operational parameters affecting the removal process, especially when heavy metal ions are present in concoction as in real systems. Given the proven efficiency of multifunctional TiO2/Alg/FeNPs magnetic beads for the removal of model organic pollutants, this study investigated the possibility to exploit such system also for the removal of mixed heavy metals (MHM), specifically Cr(III), Cu(II), and Pb(II) ions, under ultraviolet irradiation at a wavelength of 254 nm. After a preliminary screening on the optimal catalyst loading, operating parameters such as the initial concentration of metal ions, contact and irradiation time, and pH were investigated to optimize the removal of metal ions using response surface methodology (RSM) via Box–Behnken design. Starting from a MHM solution containing 44 ppm of each metal ion, the removal of Pb(II), Cr(III), and Cu(II) ions in the aqueous solution was nearly completed (>98.4%) for all three ions within 72 min of irradiation at almost neutral pH (pH = 6.8). The stability of TiO2/Alg/FeNPs was confirmed by retrieving and reusing the beads in three consecutive cycles of heavy metals removal without observing significant changes in catalyst efficiency. 相似文献
4.
5.
Micro‐evolution of the hepatitis B virus genome in hepatitis B e‐antigen‐positive carriers: Comparison of genotypes B and C at various immune stages 下载免费PDF全文
6.
7.
Diabetes mellitus(DM) negatively affects the development and progression of chronic liver diseases(CLD) of various etiologies. Concurrent DM and CLD are also associated with worse clinical outcomes with respect to mortality, the occurrence of hepatic decompensation, and the development of hepatocellular carcinoma(HCC). Unfortunately, early diagnosis and optimal treatment of DM can be challenging, due to the lack of established clinical guidelines as well as the medical complexity of this patient population. We conducted an exploratory review of relevant literature to provide an up-to-date review for internists and hepatologists caring for this patient population. We reviewed the epidemiological and pathophysiological associations between DM and CLD, the impact of insulin resistance on the progression and manifestations of CLD, the pathogenesis of hepatogenic diabetes, as well as the practical challenges in diagnosis and monitoring of DM in this patient population. We also reviewed the latest clinical evidence on various pharmacological antihyperglycemic therapies with an emphasis on liver disease-related clinical outcomes. Finally, we proposed an algorithm for managing DM in patients with CLD and discussed the clinical and research questions that remain to be addressed. 相似文献
8.
9.
10.
Heather R. Nolan Juan Gurria Jose L. Peiro Sammy Tabbah Ramiro Diaz-Primera William Polzin Mounira Habli Foong-Yen Lim 《Journal of pediatric surgery》2019,54(6):1153-1158
PurposeCongenital high airway obstruction syndrome (CHAOS) is a devastating fetal condition of complete airway discontinuity resulting in significant hydrops and extreme lung hyperplasia. It is universally fatal with survival reported only in the rare spontaneous fistulization or EXIT intervention (Ex Utero Intrapartum Treatment). Even in these cases, mortality remains high, and current investigations are targeting prenatal interventions. This report describes our experience with management and fetal interventions for CHAOS, including laser laryngotomy.MethodsWe retrospectively reviewed all patients diagnosed with CHAOS at a single academic institution between 2006 and 2017.ResultsFifteen patients were identified. Eight had obstruction at the trachea and seven at the larynx. In the laryngeal obstructions, three expired shortly after birth, and one survived after spontaneous fistulization and subsequent EXIT to tracheostomy. The remaining three underwent in-utero treatment with laser laryngotomy. One had preterm premature rupture of membranes (PPROM), delivered 3 days post-operatively, and died. Two underwent EXIT to tracheostomy with one surviving to discharge and is currently 2 years old.ConclusionOur study demonstrates the outcomes of a large series of patients diagnosed with CHAOS. While mortality remains high, options for fetal intervention are being explored to allow alterations in the prenatal natural history and improve postnatal outcomes.Type of StudyRetrospective Treatment Study.Level of EvidenceLevel IV. 相似文献