排序方式: 共有34条查询结果,搜索用时 0 毫秒
1.
Angelo V. Vasiliadis Andreas Zafeiridis Konstantina Dipla Nikiforos Galanis Dimitrios Chatzidimitriou Antonios Kyparos Michalis G. Nikolaidis Ioannis S. Vrabas 《The journal of spinal cord medicine》2014,37(2):226-232
Objective
Individuals with spinal cord injury (SCI) show structural and functional vascular maladaptations and muscle loss in their lower limbs. Angiogenic biomolecules play important roles in physiological and pathological angiogenesis, and are implicated in the maintenance of muscle mass. This study examined the responses of angiogenic molecules during upper-limb aerobic exercise in patients with SCI and in able-bodied (AB) individuals.Methods
Eight SCI patients with thoracic lesions (T6–T12, ASIA A) and eight AB individuals performed an arm-cranking exercise for 30 minutes at 60% of their VO2max. Plasma concentrations of vascular endothelial growth factor (VEGF-A165), VEGF receptor 1 (sVEGFr-1), VEGF receptor 2 (sVEGFr-2), metalloproteinase 2 (MMP-2), and endostatin were measured at rest, after exercise, and at 1.5 and 3.0 hours during recovery.Results
The two-way analysis of variance showed non-significant main effects of “group” and significant main effects of “time/exercise” for all angiogenic biomolecules examined (P < 0.01–0.001). The arm-cranking exercise significantly increased plasma concentrations of VEGF, sVEGFr-1, sVEGFr-2, MMP-2, and endostatin in both groups (P < 0.001–0.01). The magnitude of the increase was similar in both patients with SCI and AB individuals, as shown by the non-significant group × time interaction for all angiogenic parameters.Conclusions
Upper-limb exercise (arm-cranking for 30 minutes at 60% of VO2max) is a sufficient stimulus to trigger a coordinated circulating angiogenic response in patients with SCI. The response of angiogenic molecules to upper-limb aerobic exercise in SCI appears relatively similar to that observed in AB individuals. 相似文献2.
John V. Asimakopoulos Maria K. Angelopoulou Maria-Panagiota Arapaki Alexandros Kanellopoulos Maria Dimou Xanthoula Giakoumis Eliana Konstantinou Marina Belia Chrysovalantou Chatzidimitriou Sotirios Sachanas Theodoros Iliakis Marie-Christine Kyrtsonis Marina P. Siakantaris Nora-Athina Viniou Eleni Variamis Flora N. Kontopidou Gerassimos A. Pangalis Panayiotis Panayiotidis Kostas Konstantopoulos Theodoros P. Vassilakopoulos 《British journal of haematology》2020,190(6):e335-e339
3.
Irene Fragiadaki Stavros Papadakis Georgia Sevastaki Katerina Sfyridaki Irene Mavroudi George N. Goulielmos Peggy Kanellou Anette Mörtberg Petter Höglund Katerina Gemenetzi Kostas Stamatopoulos Anastasia Chatzidimitriou Jan Palmblad Helen A. Papadaki 《American journal of hematology》2020,95(7):E163-E166
4.
5.
6.
Changes in antibiotic resistance of the most common Gram-negative bacteria isolated in intensive care units 总被引:4,自引:0,他引:4
Makedou KG Tsiakiri EP Bisiklis AG Chatzidimitriou M Halvantzis AA Ntoutsou K Alexiou-Daniel S 《The Journal of hospital infection》2005,60(3):245-248
We studied the changes in antibiotic resistance of the most common Gram-negative bacteria isolated in the intensive care units at our hospital in 2000 and 2002. Bacterial identification was performed by use of the VITEK 60 analyser, and antibiotic susceptibilities were tested by the VITEK 60 analyser and the disk diffusion agar method. The bacteria isolated most frequently were Pseudomonas aeruginosa (132 strains in 2000 and 106 in 2002), Acinetobacter calcoaceticus (98 and 109 strains, respectively) and Klebsiella pneumoniae (53 and 83 strains, respectively). Acinetobacters presented the highest percentage resistance, with significant increases in resistance to imipenem (15% in 2000 and 67% in 2002) and piperacillin/tazobactam (41% and 72%, respectively). P. aeruginosa presented a significant increase in resistance to all antibiotics, except ceftazidime. A large increase was observed in the resistance of K. pneumoniae to amikacin (from 10% to 50%), ceftazidime (from 80% to 90%) and tobramycin (from 80% to 90%). No imipenem-resistant strains of K. pneumoniae were found. 相似文献
7.
E Vakirlis E Lazaridou TG Tzellos S Gerou D Chatzidimitriou D Ioannides 《Journal of the European Academy of Dermatology and Venereology》2011,25(4):409-416
Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with increasing frequency over the last decades, especially in adults. Cytokines orchestrate atopic skin inflammation. Objectives The aim of this study was to compare serum levels of cytokines in adult patients with acute AD (AD1) with other groups of AD patients and controls and investigate the possible association between such cytokines and disease severity. Methods We measured cytokine levels using flow cytometry in 21 adult patients with acute AD, 12 adults with chronic AD, 10 children with acute AD and 10 healthy adults. Results Flow cytometry analysis of cytokines revealed that interleukin 10 (IL‐10), IL‐6, interferon γ (IFN‐γ) and IL‐4 levels were significantly decreased in AD1 group compared with controls, whereas IL‐2 and tumour necrosis factor (TNF) did not differ. Comparison of AD1 group with adults chronic phase group showed that IgE, eosinophil and IL‐2 levels remained unaltered, whereas IL‐10, IL‐6, IFN‐γ, IL‐4 and TNF were significantly decreased. SCORAD and IgE levels were significantly increased, IL‐10, IL‐6 and IFN‐γ were decreased and TNF, IL‐2, IL‐4 and eosinophil levels remained unchanged in AD1 group compared with children acute phase group. Within AD1 group correlation analysis revealed that IgE and TNF levels were significantly associated with AD severity. Coefficient of determination analysis revealed that TNF and IgE levels could explain 49.14% and 35.28% of the variance of SCORAD. Conclusions These data indicate that serum IgE and TNF levels correlate with AD severity and that serum cytokines are downregulated in AD1 group. Further studies are clearly needed to elucidate cytokines’ role in adults with AD . 相似文献
8.
9.
Comparing Abbott m2000 RealTime HIV test and Roche COBAS Ampliprep/COBAS Taqman HIV test,v2.0 in treated HIV‐1 B and non‐B subjects with low viraemia 下载免费PDF全文
10.