全文获取类型
收费全文 | 9155篇 |
免费 | 548篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 90篇 |
儿科学 | 285篇 |
妇产科学 | 169篇 |
基础医学 | 1178篇 |
口腔科学 | 183篇 |
临床医学 | 667篇 |
内科学 | 2217篇 |
皮肤病学 | 288篇 |
神经病学 | 1032篇 |
特种医学 | 368篇 |
外国民族医学 | 1篇 |
外科学 | 1113篇 |
综合类 | 14篇 |
一般理论 | 1篇 |
预防医学 | 662篇 |
眼科学 | 112篇 |
药学 | 647篇 |
中国医学 | 4篇 |
肿瘤学 | 700篇 |
出版年
2023年 | 73篇 |
2022年 | 62篇 |
2021年 | 229篇 |
2020年 | 139篇 |
2019年 | 196篇 |
2018年 | 417篇 |
2017年 | 265篇 |
2016年 | 279篇 |
2015年 | 315篇 |
2014年 | 359篇 |
2013年 | 526篇 |
2012年 | 628篇 |
2011年 | 523篇 |
2010年 | 386篇 |
2009年 | 312篇 |
2008年 | 414篇 |
2007年 | 418篇 |
2006年 | 426篇 |
2005年 | 420篇 |
2004年 | 381篇 |
2003年 | 320篇 |
2002年 | 331篇 |
2001年 | 203篇 |
2000年 | 165篇 |
1999年 | 262篇 |
1998年 | 48篇 |
1997年 | 41篇 |
1996年 | 25篇 |
1995年 | 34篇 |
1994年 | 20篇 |
1993年 | 26篇 |
1992年 | 138篇 |
1991年 | 153篇 |
1990年 | 124篇 |
1989年 | 126篇 |
1988年 | 107篇 |
1987年 | 110篇 |
1986年 | 74篇 |
1985年 | 76篇 |
1984年 | 62篇 |
1983年 | 46篇 |
1982年 | 29篇 |
1979年 | 46篇 |
1978年 | 25篇 |
1976年 | 43篇 |
1974年 | 22篇 |
1973年 | 37篇 |
1972年 | 25篇 |
1971年 | 26篇 |
1968年 | 24篇 |
排序方式: 共有9731条查询结果,搜索用时 15 毫秒
1.
Martin R. Späth Malte P. Bartram Nicolàs Palacio-Escat K. Johanna R. Hoyer Cedric Debes Fatih Demir Christina B. Schroeter Amrei M. Mandel Franziska Grundmann Giuliano Ciarimboli Andreas Beyer Jayachandran N. Kizhakkedathu Susanne Brodesser Heike Göbel Jan U. Becker Thomas Benzing Bernhard Schermer Martin Höhne Markus M. Rinschen 《Kidney international》2019,95(2):333-349
2.
Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep
下载免费PDF全文
![点击此处可从《Journal of pineal research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Flavio Torres Alejandro González‐Candia Camilo Montt Germán Ebensperger Magdalena Chubretovic María Serón‐Ferré Roberto V. Reyes Aníbal J. Llanos Emilio A. Herrera 《Journal of pineal research》2015,58(3):362-373
Pulmonary hypertension of the newborn (PHN) constitutes a critical condition with severe cardiovascular and neurological consequences. One of its main causes is hypoxia during gestation, and thus, it is a public health concern in populations living above 2500 m. Although some mechanisms are recognized, the pathophysiological facts that lead to PHN are not fully understood, which explains the lack of an effective treatment. Oxidative stress is one of the proposed mechanisms inducing pulmonary vascular dysfunction and PHN. Therefore, we assessed whether melatonin, a potent antioxidant, improves pulmonary vascular function. Twelve newborn sheep were gestated, born, and raised at 3600 meters. At 3 days old, lambs were catheterized and daily cardiovascular measurements were recorded. Lambs were divided into two groups, one received daily vehicle as control and another received daily melatonin (1 mg/kg/d), for 8 days. At 11 days old, lung tissue and small pulmonary arteries (SPA) were collected. Melatonin decreased pulmonary pressure and resistance for the first 3 days of treatment. Further, melatonin significantly improved the vasodilator function of SPA, enhancing the endothelial‐ and muscular‐dependent pathways. This was associated with an enhanced nitric oxide‐dependent and nitric oxide independent vasodilator components and with increased nitric oxide bioavailability in lung tissue. Further, melatonin reduced the pulmonary oxidative stress markers and increased enzymatic and nonenzymatic antioxidant capacity. Finally, these effects were associated with an increase of lumen diameter and a mild decrease in the wall of the pulmonary arteries. These outcomes support the use of melatonin as an adjuvant in the treatment for PHN. 相似文献
3.
4.
5.
6.
7.
Objective
To explore from a gender perspective the association with subjective health of the interaction between education and household arrangements within the framework of social determinants of health placed at the micro and mezzo levels.Methods
The data comes from the Spanish sample of the European Union Statistics on Income and Living Conditions for 2014. Independent logistic regression models for men and women were run to analyze the association with subjective health of the interaction between education and household arrangements. An additive model was run to assess possible advantages over the interaction approach.Results
The interaction models show a lower or even no significant effect on health of household arrangements usually negatively associated with health among individuals with high education, displaying specific patterns according to sex.Conclusions
Health profiles of women and men are more precisely drawn if both social determinants of health are combined. Among the women, the important role was confirmed of both social determinants of health in understanding their health inequalities. Among the men, mainly those with low educational achievement, the interaction revealed that the household was a more meaningful social determinant of health. This could enable the definition of more efficient public policies to reduce health and gender inequalities. 相似文献8.
9.
In brain regions containing noradrenergic (NA) cell bodies or terminals, DSP-4 induces changes in the activity of catecholamine-synthesizing enzymes which suggest that central NA neurons are lesioned by this neurotoxin. In contrast, the lack of change in the same enzymatic activities in an area containing mostly adrenergic (A) neurons (C2 region), favors the hypothesis of a resistance of the A neurons to DSP-4. Furthermore, the enzymatic changes observed in peripheral organs suggest a peripheral activation of the NA cell bodies in response to lesioning of the sympathetic terminals by DSP-4. 相似文献
10.