全文获取类型
收费全文 | 805篇 |
免费 | 54篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 45篇 |
妇产科学 | 2篇 |
基础医学 | 82篇 |
口腔科学 | 18篇 |
临床医学 | 73篇 |
内科学 | 267篇 |
皮肤病学 | 8篇 |
神经病学 | 42篇 |
特种医学 | 83篇 |
外科学 | 90篇 |
综合类 | 64篇 |
预防医学 | 30篇 |
眼科学 | 8篇 |
药学 | 31篇 |
肿瘤学 | 22篇 |
出版年
2024年 | 2篇 |
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 10篇 |
2020年 | 6篇 |
2019年 | 9篇 |
2018年 | 12篇 |
2017年 | 7篇 |
2016年 | 11篇 |
2015年 | 21篇 |
2014年 | 22篇 |
2013年 | 28篇 |
2012年 | 26篇 |
2011年 | 26篇 |
2010年 | 28篇 |
2009年 | 44篇 |
2008年 | 27篇 |
2007年 | 47篇 |
2006年 | 47篇 |
2005年 | 25篇 |
2004年 | 34篇 |
2003年 | 19篇 |
2002年 | 22篇 |
2001年 | 21篇 |
2000年 | 16篇 |
1999年 | 18篇 |
1998年 | 44篇 |
1997年 | 32篇 |
1996年 | 42篇 |
1995年 | 19篇 |
1994年 | 20篇 |
1993年 | 24篇 |
1992年 | 6篇 |
1991年 | 10篇 |
1990年 | 6篇 |
1989年 | 16篇 |
1988年 | 26篇 |
1987年 | 11篇 |
1986年 | 10篇 |
1985年 | 23篇 |
1984年 | 12篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 3篇 |
排序方式: 共有866条查询结果,搜索用时 15 毫秒
1.
Shafi Mussa Tash Prior Nicholas Alp Kathryn Wood Keith M Channon David P Taggart 《European journal of cardio-thoracic surgery》2004,26(5):988-994
OBJECTIVE: Radial arteries are increasingly used as conduits for coronary artery bypass grafts, but perioperative graft vasospasm remains a concern. In vitro testing has demonstrated the efficacy of phenoxybenzamine and verapamil/nitroglycerin as topical antispasmodic agents, but their duration of action in vivo is unknown. Using an in vivo mouse model, we measured their duration of action in functioning vascular grafts, and compared this to their in vitro duration of action in ungrafted vascular segments. METHODS: Two millimetre mouse aortic segments (C57/BL6) were incubated with phenoxybenzamine, verapamil/nitroglycerin, or buffer (controls) for 15 min in organ chambers. Isometric tension responses to phenylephrine and prostaglandin F2alpha were measured at 0, 2, 6 and 12 h post-incubation. In parallel, 36 murine infrarenal aortic interposition grafts (2 mm) were performed. Twelve grafts were pre-treated (15 min) with phenoxybenzamine, 12 with verapamil/nitroglycerin and 12 remained untreated (controls). Isometric tension responses to the same agonists were measured in grafts harvested 2, 6, 13 and 23 h after surgery. RESULTS: Phenoxybenzamine prevented alpha-adrenergic vasoconstriction for up to 16 h in vivo (grafts), and 12h in vitro (ungrafted segments). Verapamil/nitroglycerin was effective for at least 2 h in vitro, but did not prevent vasoconstriction after 2 h in vivo. CONCLUSIONS: The mouse model appears to be a useful technique for assessing the pharmacological properties of antispasmodic agents in vivo. Phenoxybenzamine has an extended action in arterial grafts in vivo. Verapamil/nitroglycerin is short-lived in vivo but lasts longer in vitro. Measurements of antispasmodic duration of action in vitro should be interpreted with caution. 相似文献
2.
3.
4.
5.
6.
7.
8.
9.
Bals-Pratsch M; De Geyter C; Muller T; Frieling U; Lerchl A; Pirke KM; Hanker JP; Becker-Carus C; Nieschlag E 《Human reproduction (Oxford, England)》1997,12(5):896-904
Preliminary data have suggested that female infertility due to corpus
luteum insufficiency may be caused by subclinical hypothyroidism
[exaggerated thyroid-stimulating hormone (TSH) response to thyrotrophin-
releasing hormone (TRH) stimulation]. L-Thyroxine supplementation has been
recommended to achieve pregnancies in subclinical hypothyroid women. This
controlled study was carried out in order to investigate the biochemical
diagnosis of subclinical hypothyroidism as a possible infertility factor.
Five infertile patients (aged 25-36 years) with subclinical hypothyroidism
(n = 4, stimulated TSH >20 microU/ml) or primary hypothyroidism (n = 1)
and five healthy controls (aged 22-39 years) with normal thyroid function
(stimulated TSH <15 microU/ml), regular cycles and no history of
infertility were studied in the early follicular phase. In the pre-study
evaluation, eight of 23 volunteers (34.8%) had to be excluded because of
subclinical hypothyroidism with stimulated TSH values (TSHs) >15
microU/ml. Cycle function of patients and controls was compared by the
method of LH pulse pattern analysis. Therefore blood samples were drawn
every 10 min during a 24 h period. Sleep was recorded from midnight to 7
a.m. Repetition of the TRH tests at the end of the 24 h blood sampling
period confirmed the difference in stimulated TSH values of the two study
groups. Pulse analysis for luteinizing hormone (LH), TSH and prolactin
showed no differences between patients and controls for pulse frequency,
amplitude, height, length, area under curve (AUC) and the 24 h mean. Even
the hypothyroid patient had a normal LH pulse pattern. Additional
measurement of melatonin in pooled sera every 30 min gave the
well-documented diurnal profiles during day and night for both groups.
Patients had significantly higher melatonin values at seven time points
during the night. Peaks for LH, TSH, prolactin and cortisol were correlated
with the sleep stages wake, rapid eye movement, 1 + 2 and 3 + 4. We
concluded that corpus luteum insufficiency in female infertility cannot be
explained by subclinical hypothyroidism and thus should not be treated with
L-thyroxine for fertility reasons.
相似文献
10.