全文获取类型
收费全文 | 201篇 |
免费 | 10篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 69篇 |
妇产科学 | 3篇 |
基础医学 | 13篇 |
口腔科学 | 14篇 |
临床医学 | 12篇 |
内科学 | 25篇 |
皮肤病学 | 3篇 |
神经病学 | 16篇 |
特种医学 | 4篇 |
外科学 | 19篇 |
预防医学 | 3篇 |
眼科学 | 6篇 |
药学 | 11篇 |
中国医学 | 1篇 |
肿瘤学 | 6篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 9篇 |
2020年 | 6篇 |
2019年 | 6篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 13篇 |
2015年 | 6篇 |
2014年 | 6篇 |
2013年 | 20篇 |
2012年 | 11篇 |
2011年 | 15篇 |
2010年 | 4篇 |
2009年 | 3篇 |
2008年 | 16篇 |
2007年 | 12篇 |
2006年 | 23篇 |
2005年 | 17篇 |
2004年 | 19篇 |
2003年 | 4篇 |
2002年 | 5篇 |
排序方式: 共有212条查询结果,搜索用时 15 毫秒
1.
Gözde Bumin Aydın Reyhan Polat Julide Ergil Murat Sayın Ceyda Özhan Çaparlar 《Journal of anesthesia》2014,28(3):471-474
Rocuronium is a non-depolarizing neuromuscular blocking agent which is associated with injection pain and induces withdrawal movement of the injected hand or arm or generalized movements of the body after intravenous injection. The aim of this randomized study was to compare the efficacy of pretreatment with oral dexketoprofen trometamol (Arvelles®; Group A) with placebo (Group P) without tourniquet to prevent the withdrawal response caused by rocuronium injection. The study cohort comprised 150 American Society of Anaesthesiologists class I–III patients aged 18–75 years who were scheduled to undergo elective surgery with general anesthesia. The patients response to rocuronium was graded using a 4-point scale [0 = no response; 1 = movement/withdrawal at the wrist only, 2 = movement/withdrawal involving the arm only (elbow/shoulder); 3 = generalized response]. The overall incidence of withdrawal movement after rocuronium injection was significantly lower in Group A (30.1 %) than in Group P (64.6 %) (p < 0.001). The incidence of score 0 withdrawal movements was higher in Group A (69.9 %) than in Group P (35.4 %), that of score 1 withdrawal movements was similar between groups (Group A 21.9 %; Group B 26.1 %) (p = 0.560) and that of score 2 withdrawal movements was lower in Group A (8.2 %) than in Group P (38.5 %) (p < 0.001). There were no score 3 withdrawal movements in either group (p > 0.05). These results demonstrate that the preemptive administration of dexketoprofen trometamol can attenuate the degree of withdrawal movements caused by the pain of the rocuronium injection. 相似文献
2.
3.
Premenstrual syndrome is a term which is used for describing of somatic, cognitive, emotional, and behavioral symptoms that occur during the luteal phase of menstrual cycle in women of reproductive age; symptoms rapidly improve at the onset of menstruation. In this study, we aimed to reveal if cognitive functions are affected or not in PMS and if the subjects are affected, we try to explain this situation by an objective diagnostic test. Ethical committee approval was taken for this project on 09.03.2012 and numbered 050.99-60. In this study, in order to determine premenstrual syndrome, “Premenstrual Syndrome Scale” that is developed by Gençdo?an (2006) with 44 items, Likert type, and 9 subgroups was used. Sample size was calculated using simple random sampling with a confidence level of 95% and confidence interval of 0.05. A total of 60 participants were included in the study (calculated sample size was 30 for each group). Each group was recorded in the ENMG-UP laboratory using the OIP auditory warning and the “oddball two-tone discrimination task” method. Latency measurements were taken from the highest point of the peak, and amplitude measurements were taken from peak to peak with a cursor. Comparisons of P300 wave latencies obtained via sparse auditory stimulus in PMS and non-PMS groups were made and findings were summarized in one of the tables. Recordings are taken from three scalp regions: parietal and central, respectively. PMS women have longer P300 wave latencies in all regions compared to non-PMS group, whereas there is no significant difference between P300 amplitude. 相似文献
4.
5.
A platinum blue complex exerts its cytotoxic activity via DNA damage and induces apoptosis in cancer cells
下载免费PDF全文
![点击此处可从《Chemical biology & drug design》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Zelal Adiguzel Seniz Ozalp‐Yaman Gokalp Celik Safia Salem Tugba Bagci‐Onder Filiz Senbabaoglu Yüksel Cetin Ceyda Acilan 《Chemical biology & drug design》2017,90(2):210-224
Here, we describe the characteristics of a Pt‐blue complex [Pt4(2‐atp)8(H2O)(OH)] (2‐atp: 2‐aminothiophenol) as a prodrug for its DNA‐binding properties and its use in cancer therapy. The nature of the interaction between the Pt‐blue complex and DNA was evaluated based on spectroscopic measurements, the electronic absorption spectra, thermal behavior, viscosity, fluorometric titration, and agarose gel electrophoresis. Our results suggested that the compound was able to partially intercalate DNA and appeared to induce both single‐ and double‐stranded breaks (DBS) on DNA in vitro, but no DSBs in cells. The ability of the compound to induce DNA damage was dependent on reactive oxygen species (ROS) in vitro. There was also elevated formation of ROS and SOD expression in response to drug treatment in cell culture. The complex was found to be more cytotoxic to cancer cells in comparison with noncancer controls using WST‐1 assay. The mean of cell death was determined to be apoptosis as assessed via biochemical, morphological, and molecular observations, including DNA condensation/fragmentation analysis, live cell imaging microscopy, TUNEL analyses, and increase in the levels of pro‐apoptotic genes such as Bag3, Bak, Bik, Bmf, and Hrk. Hence, the Pt‐blue complex under study grants premise for further studies. 相似文献
6.
7.
Javad Sharifi‐Rad Shahira M. Ezzat Mahitab H. El Bishbishy Dima Mnayer Farukh Sharopov Ceyda S. Kl Monica Neagu Carolina Constantin Mehdi Sharifi‐Rad Maria Atanassova Silvana Nicola Giuseppe Pignata Bahare Salehi Patrick V. T. Fokou Natlia Martins 《Phytotherapy research : PTR》2020,34(7):1474-1518
Rosmarinus species are aromatic plants that mainly grow in the Mediterranean region. They are widely used in folk medicine, food, and flavor industries and represent a valuable source of biologically active compounds (e.g., terpenoids, flavonoids, and phenolic acids). The extraction of rosemary essential oil is being done using three main methods: carbon dioxide supercritical extraction, steam distillation, and hydrodistillation. Furthermore, interesting antioxidant, antibacterial, antifungal, antileishmanial, anthelmintic, anticancer, anti‐inflammatory, antidepressant, and antiamnesic effects have also been broadly recognized for rosemary plant extracts. Thus the present review summarized data on economically important Rosmarinus officinalis species, including isolation, extraction techniques, chemical composition, pharmaceutical, and food applications. 相似文献
8.
Cok G Parildar Z Basol G Kabaroglu C Bayindir U Habif S Bayindir O 《Clinical biochemistry》2007,40(12):876-880
OBJECTIVES: Neopterin is produced by stimulated macrophages under the influence of gamma interferon of lymphocyte origin. It is regarded as a biochemical marker of cell-mediated immune response. This study was designed to assess the diagnostic value of pleural fluid neopterin levels in tuberculous pleurisy in comparison with adenosine deaminase activity. DESIGN AND METHODS: Pleural fluid adenosine deaminase (ADA) activity and neopterin levels were measured in 16 patients with tuberculous pleurisy (TP) and 19 patients with malignant pleurisy (MP). ADA activity was determined by a colorimetric method, whereas neopterin levels were determined by a reversed-phase liquid chromatography technique. All values were given as median (min-max). RESULTS: The mean age was 45.43+/-20.39 years in the TP group and 60.42+/-11.02 years in the MP group (p=0.026). The median pleural fluid ADA activity was 51.75 U/L (3.50-62.40 U/L) in the TP group and was 2.30 U/L (1-8.20 U/L) in the MP group. The difference was statistically significant (p<0.001). The median pleural fluid neopterin levels were 13.15 nmol/L (1.86-59.50 nmol/L) and 2.44 nmol/L (0.92-27.60 nmol/L) in the TP group and the MP group, respectively (p=0.021). In order to evaluate the diagnostic value of pleural fluid neopterin concentrations, receiver-operating-characteristic curve analysis was performed. CONCLUSION: Pleural fluid neopterin concentration is significantly higher in TP when compared to MP, however when compared, its clinical use as a diagnostic marker is not valuable as ADA. 相似文献
9.
Bayindir O Ozmen D Mutaf I Turgan N Habif S Gülter C Parildar Z Uysal A 《Annals of nutrition & metabolism》2002,46(5):222-228
10.
Karadeniz C Oguz A Ataoglu O Citak C Buyan N Pinarli G Ozkaya O Kapucu O 《Journal of nephrology》2002,15(5):597-600
Primary renal non-Hodgkin's lymphoma is very rare in childhood. A six-year-old boy presented with bilateral non-obstructive multinodular nephromegaly and renal failure. Percutaneous needle biopsy showed large-cell lymphoma. The patient was started on chemotherapy. A right nephrectomy was done when systemic hypertension developed in the presence of a non-functional right kidney. Histopathologic examination revealed focal lymphomatous infiltration and xanthogranulomatous pyelonephritis which is an atypical form of chronic renal infection. The case is discussed in relation to previons reports. 相似文献