全文获取类型
收费全文 | 97篇 |
免费 | 6篇 |
专业分类
基础医学 | 6篇 |
口腔科学 | 3篇 |
临床医学 | 3篇 |
内科学 | 80篇 |
神经病学 | 5篇 |
综合类 | 1篇 |
预防医学 | 3篇 |
药学 | 2篇 |
出版年
2021年 | 4篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 2篇 |
2013年 | 4篇 |
2012年 | 3篇 |
2011年 | 6篇 |
2010年 | 1篇 |
2008年 | 8篇 |
2007年 | 2篇 |
2006年 | 4篇 |
2005年 | 5篇 |
2004年 | 7篇 |
2003年 | 4篇 |
2002年 | 8篇 |
2001年 | 3篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1978年 | 3篇 |
1974年 | 1篇 |
1973年 | 3篇 |
排序方式: 共有103条查询结果,搜索用时 31 毫秒
1.
2.
Identifying the special needs of children with Type 1 diabetes in the school setting. An overview of parents' perceptions. 总被引:1,自引:0,他引:1
AIMS: The aims of this observational study were to identify the special needs of children with Type 1 diabetes in schools from the parents' point of view and the difficulties experienced with full integration, and to define a series of interventions which may improve the situation. METHODS: Parents of children aged 3-18 years with Type 1 diabetes were eligible. Those who agreed to participate completed a self-reporting questionnaire which determined the effects of the disease on children, parents and school personnel, and addressed aspects including children's integration, glycaemic control, insulin administration, meals, sports, trips and attitudes of teachers and school colleagues to their disease. RESULTS: A total of 499 questionnaires were completed and validated. Median age of children was 11.5 years (95% CI 7.8-15.2). Only 34% of parents believed that teachers could recognize the symptoms of a mild hypoglycaemic episode. Seventeen per cent of parents experienced problems at their schools when they informed staff about their children's disease, 5% were finally not accepted and 8% were forced to change school. In some cases, they had to modify glucose monitoring (9%) and treatment administration (16%) because of a lack of cooperation from the school. CONCLUSIONS: Training sessions on Type 1 diabetes, an increase in the number of nurses, better availability of resources from diabetic associations to schools and improved communication between school personnel and parents were identified as key factors that may improve the full integration of the diabetic child in this setting. 相似文献
3.
Gonzalo Domínguez Eladio Cardiel Elsa Snchez Pablo-Rogelio Hernndez 《Journal of radiation research》2021,62(2):259
To assess the effects of exposure to extremely low-frequency magnetic fields (ELF-MFs) on MDCK cell lines, experiments were performed in a chamber under controlled conditions (temperature, humidity and CO2). Therefore, the measured physicochemical and electrical changes in the cells are due solely to the magnetic field exposure and not to external factors. A developed sinusoidal magnetic field generator produced the ELF-MFs with a uniform magnetic field and adjustable intensity and frequency. Three experimental indicators were used: (i) transepithelial electrical impedance (TEEI); (ii) cell migration and proliferation; and (iii) expression of the proteins of the tight junctions, and changes in the area and shape of the cell nuclei. No significant effects on TEEI values were observed when 10 and 50 G 60 Hz magnetic fields were applied to confluent cell monolayers. There were no significant differences in migration and proliferation of the cell monolayer exposed to 60 Hz magnetic fields10 and 50 G , but a contact inhibition factor was observed. The expression of the CLDN-1 protein decreased by 90% compared with the control, while ZO-1 protein expression increased by 120%. No significant effects were observed in the area and shape of the cell nuclei. Experimentation in a controlled environment, under physiological conditions, ensures that the observed effects were strictly due to exposure to magnetic fields. Different exposure conditions are necessary to determine the impact on TEEI and cell migration–proliferation indicators. 相似文献
4.
Rodríguez-Carreón AA Zúñiga J Hernández-Pacheco G Rodríguez-Pérez JM Pérez-Hernández N Montes de Oca JV Cardiel MH Granados J Vargas-Alarcón G 《Journal of autoimmunity》2005,24(1):63-68
The aim of this study was to determine the frequency and potential relevance of the promoter polymorphisms of the tumor necrosis factor-alpha (TNF-alpha) in the severity of rheumatoid arthritis (RA) in Mexicans. HLA-DR and polymorphisms at positions -238 and -308 of TNF-alpha gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were typed for HLA-DR). We observed an increased frequency of HLA-DR4 in severe RA compared to healthy controls (pC=0.02, OR=2.33). TNF polymorphism analysis showed a significant increased frequency of TNF -238 GG genotype in the whole group of RA patients when compared to healthy controls (pC=0.007, OR=4.71). When the analyses were carried out separately in severe and non-severe RA patients, the increased frequency of -238 GG genotype only was observed in patients with non-severe forms of the disease. Analysis of -308 polymorphism showed increased frequency of -308 T2 (A) allele in severe RA when compared to non-severe disease (pC=0.011, OR=3.29) and to healthy controls (pC=0.002, OR=3.97). The data demonstrate that -308 T2 (A) allele is associated with susceptibility to develop severe RA in Mexicans. This association could be independent from HLA-DR alleles and might be used as a prognostic marker for severe RA. 相似文献
5.
6.
Fernández-Ávila Daniel Gerardo Patino-Hernandez Daniela Kowalskii Sergio Vargas-Caselles Alfredo Sapag Ana Maria Cachafeiro-Vilar Antonio Meléndez-Muñoz Lucia Santiago-Pastelín Carlos Graf Cesar Rossetto Chayanne Palleiro Daniel Trincado Daniela Fernández-Ávila Diana Arrieta Dina Reyes Gil Then Baez Jossiel Ugarte-Gil Manuel F. Cardiel Mario Colman Nelly Chávez Nilmo Burgos Paula I Montúfar Ruben Sandino Sayonara Fuentes-Silva Yurilis Soriano Enrique R. 《Clinical rheumatology》2021,40(7):2913-2920
Clinical Rheumatology - Studies conducted by various scientific societies have shown that the demand for specialized rheumatology care is greater than the projected growth of the workforce. Our... 相似文献
7.
Antiphospholipid arterial vasculopathy 总被引:6,自引:0,他引:6
We describe 3 relatively young patients who developed arterial occlusions in a limb requiring amputation. All 3 had antiphospholipid antibodies (APLA). In one, these appeared as part of the clinical and serologic spectrum of systemic lupus erythematosus and in the other 2 as a component of a primary antiphospholipid syndrome. Their arterial angiograms showed gradual narrowing of the arterial lumen and the histopathologic study showed striking intimal and medial proliferation as well as some increase in thickness of the adventitia. There was little evidence of thrombosis but in the 2 patients who were amputated early there was mononuclear cell infiltrate of the large arteries and in all 3 there was also leukocytoclastic vasculitis in the skin and/or muscle. We believe this represents a new form of vasculopathy, probably related to the presence of APLA, possibly triggered by the occurrence of vasculitis. 相似文献
8.
Weckmann AL Granados J Cardiel MH Andrade F Vargas-Alarcón G Alcocer-Varela J Alarcón-Segovia D 《Clinical and experimental rheumatology》1999,17(1):91-94
OBJECTIVE: The aim of this study was to determine the HLA antigens in Mexican Mestizo patients with mixed connective tissue disease (MCTD). METHODS: We studied 30 patients with MCTD and 99 healthy controls. HLA-A, -B, and -DQ antigens were typed by microlymphocytotoxicity assays. DRB1, DQA1 and DQB1 alleles were oligotyped. RESULTS: HLA-A2 and HLA-B35 were the most frequent MHC class I alleles in MCTD patients, although they were not statistically more frequent than in the controls. According to serological tests, the most frequent DQ allele in the patients was DQ1, which was statistically increased when compared with controls (p = 0.0051). By oligotyping, the DR1 allele and the DQB1*0501 specificities were significantly increased in the patients vs. controls (p = 0.032 and 0.027, respectively). CONCLUSION: The elevated levels of DQ1 found in Mexican MCTD patients, although weak, may indicate a particular genetic susceptibility, since there are previous reports of associations of other alleles (such as DR4) with MCTD in other populations. The increase in DQB1*0501 may account for the increase in DQ1. DQB1*0501 has also been reported in black patients with anti-RNP autoantibodies, compared with black patients without anti-RNP or anti-Sm. 相似文献
9.
Strozzi Alfonso Gastelum Peláez-Ballestas Ingris Granados Ysabel Burgos-Vargas Rubén Quintana Rosana Londoño John Guevara Sergio Vega-Hinojosa Oscar Alvarez-Nemegyei José Juarez Vicente Pacheco-Tena César Cedeño Ligia Garza-Elizondo Mario Santos Ana María Goycochea-Robles María Victoria Feicán Astrid García Hazel Julian-Santiago Flor Crespo María Elena Rodriguez-Amado Jacqueline Rueda Juan Camilo Silvestre Adriana Esquivel-Valerio Jorge Rosillo Celenia Gonzalez-Chavez Susana Alvarez-Hernández Everardo Loyola-Sanchez Adalberto Navarro-Zarza Eduardo Maradiaga Marco Casasola-Vargas Julio Sanatana Natalia Garcia-Olivera Imelda Goñi Mario Sanin Luz Helena Gamboa Rocío Cardiel Mario Humberto Pons-Estel Bernardo A. 《Clinical rheumatology》2020,39(9):2715-2726
Clinical Rheumatology - Although low back pain (LBP) is a high-impact health condition, its burden has not been examined from the syndemic perspective. To compare and assess clinical,... 相似文献
10.
BACKGROUND: This study was undertaken in order to identify the prevalence and factors associated with depression in a group of patients with type 2 diabetes mellitus. METHODS: Our design consisted of a cross-sectional study at the Department of Neurology and Psychiatry of the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán in Mexico City. Study units included 189 patients with type 2 diabetes mellitus (DM). Beck Depression Inventory scale was used to measure the presence of depression, while the independent variables evaluated to explain depression were sociodemographic (gender, marital status, religion, education, occupation, socioeconomic status) and characteristics of the disease were disease duration, comorbidity, compliance, and glycemic control. RESULTS: Prevalence of depression was 39% (74 patients). The following risk factors were identified by univariate analysis: being widowed (OR 3.54, confidence interval [CI] 1.56-8.11, p = 0.0007); female (OR 2.95, CI 1.50-5.82, p = 0.006); housewife (OR 2.08, CI 1.10-3.94, p = 0.01); poor compliance (OR 2.14, CI 1.12-4.10, p = 0.01), and presence of comorbidity (OR 5.60, CI 1.51-24.5, p = 0.002). On the other hand, the most constant associations were presence of blood glucose at the last appointment >or=200 (OR 3.23, CI 1.59-6.60, p = 0.0003) and >or=250 (OR 2.15, CI 0.93-5.03, p = 0.05), as the average of the last five blood glucoses >or=200 (OR 3.67, CI 1.76-7.73, p = 0.0001), >or=250 (OR 4.07, CI 1.61-10.49, p = 0.0007) and >or=300 (OR 2.12, CI 1.48-3.02, p = 0.003). Discriminant function analysis of the variables, previously studied in univariate analysis, was carried out for the presence of depression. A stepwise model included the following variables: average of the last five blood glucoses; 2) widowed or divorced, and 3) female. CONCLUSIONS: Frequency of depression in patients with type 2 DM was high (39%). High level of blood glucose stands out as a variable associated with presence of depression. Other associations were presence of comorbidity, being a female, and being widowed or divorced. 相似文献