全文获取类型
收费全文 | 218篇 |
免费 | 4篇 |
专业分类
儿科学 | 4篇 |
妇产科学 | 2篇 |
基础医学 | 19篇 |
口腔科学 | 13篇 |
临床医学 | 35篇 |
内科学 | 72篇 |
皮肤病学 | 18篇 |
神经病学 | 3篇 |
外科学 | 34篇 |
预防医学 | 9篇 |
药学 | 12篇 |
肿瘤学 | 1篇 |
出版年
2021年 | 1篇 |
2017年 | 2篇 |
2015年 | 4篇 |
2014年 | 7篇 |
2013年 | 8篇 |
2012年 | 5篇 |
2011年 | 2篇 |
2010年 | 12篇 |
2009年 | 15篇 |
2008年 | 2篇 |
2007年 | 8篇 |
2006年 | 7篇 |
2004年 | 1篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2001年 | 3篇 |
2000年 | 5篇 |
1999年 | 8篇 |
1998年 | 11篇 |
1997年 | 7篇 |
1996年 | 17篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1993年 | 8篇 |
1992年 | 6篇 |
1991年 | 4篇 |
1990年 | 7篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 3篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1967年 | 3篇 |
1965年 | 1篇 |
1963年 | 1篇 |
1961年 | 1篇 |
1954年 | 2篇 |
1949年 | 1篇 |
1937年 | 2篇 |
排序方式: 共有222条查询结果,搜索用时 0 毫秒
1.
CARLOS HOYO-VADILLO JOS PREZ-URIZAR FRANCISCO J. L
PEZ-MU
OZ 《The Journal of pharmacy and pharmacology》1995,47(6):462-465
In this work we show that the pain-induced functional impairment model (PIFIR) can be used with cannulated rats as a useful procedure for pharmacokinetic/pharmacodynamic modelling. This model evaluates analgesia by measuring motor impairment of the right limb after intra-articular administration of uric acid. Time of contact with a rotating cylinder is referred to the control limb. We studied the pharmacokinetic and pharmacodynamics of naproxen after six peroral doses to Wistar rats, and we examined the adjuvant action of caffeine with naproxen. Surgery and blood sampling did not produce any difference on functional impairment either in rats without uric acid or in the dysfunction produced by uric acid. The relation between naproxen plasma concentration and the analgesic effect was obtained with few rats. Caffeine alone did not produce any significant modification in functional impairment but the co-administration significantly increased the effect of naproxen. Plasma levels of naproxen did not change when caffeine was co-administered. The PIFIR model with blood sampling is a suitable method for pharmacokinetic/pharmacodynamic relationship studies and is specially useful to characterize drug-drug interactions. 相似文献
2.
BASILIO CARLOS M.; TORO AMILCAR; BERNSTEIN JAIME; YOJAY LUNA 《Alcohol and alcoholism (Oxford, Oxfordshire)》1987,22(4):395-400
The effect of nicotinic acid (NA) on sleeping time induced bya single dose of ethanol or pentobarbital was studied in rats.It was found that sleeping time was markedly reduced by NA ina dose-dependent manner. The effect was observed when NA wasadministered 10 min before or after ethanol or pentobarbital,but not when given 60 min in advance. NA did not affect therate of ethanol elimination measured up to 5 hr after ethanoladministration. Rats pretreated with NA 60 min before ethanolslept longer than controls. This latter effect was not observedwith pentobarbital. These observations, together with the knownlack of effect of high liver NAD+ levels on ethanol metabolismand the rather stable NAD+ concentration in brain cells, suggestthat the effect of NA on sleeping time is not mediated by anincrease in ethanol metabolism in liver or by NAD+ or NAD+-dependentreactions in brain. Our results are consistent with a directaction of NA, or some rapidly formed derivative, on a structureor process associated with brain cell functions or membranes. 相似文献
3.
4.
Radiofrequency Ablation with an Enhanced‐Irrigation Flexible‐Tip Catheter versus a Standard‐Irrigation Rigid‐Tip Catheter 下载免费PDF全文
5.
6.
Ca2+稳态平衡的调节在少突胶质细胞功能和存活中起重要作用.大麻素CB1和CB2受体在许多细胞中调节Ca2+水平和/或K+电流.本文利用培养的少突胶质细胞中,通过增高细胞外K+浓度(50 mM诱导膜去极化,研究大麻素复合物在此过程引发钙内流中的作用.CB2受体激动剂ACEA导致去极化诱导的少突胶质细胞胞浆的Ca2+瞬变表达浓度依赖性抑制,最大效应为(94±3)%,半效应浓度(EC50)为(1.3±0.03)μM.这种作用可被CB2/CB2激动剂CP55、940、内源性大麻素类AEA和2-AG所模拟,但是CB2受体选择性激动剂JWH133没有作用.CB2受体拮抗剂AM251(1μM)也可减少细胞外高K+诱导的Ca2+反应.但不能防止ACEA(3 μM)诱发的抑制效应.然而,ACEA和AEA减少去极化诱导的Ca2+瞬变的能力在CB2受体敲除小鼠和经百日咳毒素预处理的少突胶质细胞中明显降低.内流性K2+通道阻断剂BaCI:(300 μM)和CsCl2(1 mM)降低电压诱导的Ca2+内流并部分阻断ACEA的抑制效应.本文表明,大麻素抑制少突胶质细胞中去极化诱导的Ca2+瞬变是通过包括PTX-敏感的Gi/o蛋白和阻断K2+内流通道的CB2受体依赖性和非依赖性机制. 相似文献
7.
Role of presynaptic purinoceptors and cyclic AMP on the noradrenaline release in cat cerebral arteries 总被引:1,自引:0,他引:1
FERNANDO RIVILLA MAGDALENA GÜEMES CARLOS F. SANCHEZ-FERRER CARMEN IBA
EZ MERCEDES SALAICES JESUS MARIN 《The Journal of pharmacy and pharmacology》1990,42(7):481-486
Field electrical stimulation (ES), K+ (50 mM) or ionophore X-537A (0.01 mM) induced tritium release from cat cerebral arteries preincubated with [3H]noradrenaline (NA). Adenosine and AMP (0.5 mM) did not modify tritium release caused by ionophore X-537A, but these agents and ATP (0.5 mM) significantly reduced that elicited by ES and K+; this reduction was antagonized by 1-methyl-3-isobutylxanthine (MIX; 0.05 mM). Inosine (0.5 mM) and the agonist of purinergic A2-receptors, 5'N-ethyl-carboxamide adenosine (NECA; 0.5 mM) had no effect, but the agonist of purinergic A2-receptors L-N6-phenylisopropyl adenosine (L-PIA; 0.1 mM) diminished tritium efflux caused by ES and K+. The adenosine inhibition of ES-induced radioactivity release was not affected by indomethacin (0.05 mM). MIX (0.05 mM) increased tritium release evoked by ES and K+. Agents that increase intracellular cyclic (c)AMP levels, such as dibutyryl cAMP (0.5 mM), the phosphodiesterase inhibitor Ro 20-1724 (0.1 mM), and the activators of adenylate cyclase, forskolin (0.005 mM) and NaF (2 mM) reduced tritium secretion elicited by ES and K+. However, the intracellular increase of cyclic GMP (cGMP) caused by 8-Br-cGMP did not affect this secretion. Dipyridamole (0.05 mM) and the adenosine deaminase inhibitor erythro-9-2-hydroxy-3 nonyl adenosine (EHNA; 0.1 mM) also produced inhibition of tritium secretion elicited by ES and K+. Dipyridamole reduced both the uptake of [3H]NA and [3H]adenosine.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
8.
PAUL S. PHILLIPS M.D. FERNANDO ALFONSO M.D. PALOMA ARAGONCILLO M.D. JAVIER GOICOLEA M.D. ROSANA HERNANDEZ M.D. JAVIER SEGOVIA M.D. CAMINO BANUELOS M.D. ANTONIO FERNANDEZ-ORTIZ M.D. CARLOS MACAYA M.D. 《Journal of interventional cardiology》1996,9(4):301-304
A 58-year-old woman presented with a new rapidly progressive lesion distal to a stent. This lesion was treated with atherectomy through the stem in order to characterize it pathologically. The aggressive proliferative response discovered suggested that this unusually distal lesion was produced by the trauma of her previous angioplasty . 相似文献
9.
BERNARDO LÉO WAJCHENBERG FERNANDO PRESTES CESAR CARLOS EDUARDO LEME RENATO DIDIO JÚLIO KIEFFER 《Clinical endocrinology》1978,8(3):233-236
The disappearance curves of plasma insulin after intravenous injection of unlabelled pork insulin was studied in nine young female hyperthyroid subjects with Graves' disease and eleven young female normal subjects, who served as controls. Comparison of the curves by analysis of variance did not reveal statistical differences between them (F obtained = 2.8, F F 0.05 = 4.41), implying that there was no significant differences in the transference of injected insulin from plasma to the extra-vascular space between hyper- and euthyroid subjects. The results may suggest that the metabolism of insulin is not appreciably affected in hyperthyroidism. 相似文献
10.
An ambitious breastfeeding promotion programme was launchedin Brazil in 1981 which included the use of mass media, healthpersonnel training and re-organization of health service routines.A comparison of two health surveys carried out in Greater SãoPaulo before (1981) and after (1987) the implementation of theprogramme showed an important increase in the median durationof breastfeeding from 84 to 146 days, respectively. The potentialimpact of the programme on infant mortality rates has been estimated,using the relative risks associated with breastfeeding obtainedin a case-control study in a similar urban population in southernBrazil. During this period the infant mortality rate in SãoPaulo fell by 49%. The observed change in feeding practicesmay have been responsible for a reduction of 12% of this 49%or, expressed another way, for one-quarter of the observed declinein infant mortality. The calculations suggest that the programmemay have led to reductions in deaths caused by diarrhoea of32%, in respiratory infections of 22% and in deaths due to otherinfections of 17%. 相似文献