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1.
A K Burroughs L Marelli E Cholongitas P Manousou K Rolles V Karam V Delvart R Adam C Sabin 《Liver transplantation》2007,13(6):935-6; author reply 937
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背景与目的:原发性胆汁性肝硬化(PBC)伴系统性硬化症(SSc)的预后仍不十分清楚,该研究拟对其临床特点及预后进行评估。方法:从一个含580例患者的PBC数据库中选出43例PBC伴SSc患者,同时为每例PBC—SSc患者匹配2例单纯PBC患者作为对照,监测初次就医时的血清胆红素浓度。结果:局限皮肤型SSc者40例(93%)。诊断PBC时的中位年龄为49.7岁,胆红素浓度为17μmol/L,白蛋白水平为40.5g/L。24例(56%)患者于SSc后在中值为4.9年发生PBC。配对患者诊断PBC时的中位年龄为53.2岁、胆红素浓度为12μmol/L、白蛋白水平为41g/L。两组患者中位随访时间相似:PBC—SSc组为3.16年,单纯PBC组为4.8年。PBC—SSc患者南于较少接受移植手术(HR0.068;P:0.006),在校正性别、年龄、胆红素对数及碱性磷酸酶等因素后,其移植术或死亡风险(HR0.116;P=0.01)均明显降低,同时胆红素上升的比例亦较低(P=0.04)。 相似文献
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Rosenberg ZS; Jahss MH; Noto AM; Shereff MJ; Cheung Y; Frey CC; Norman A 《Radiology》1988,167(2):489-493
Computed tomography (CT) was performed in 42 patients with 49 clinically suspected tears of the posterior tibial tendon. Twenty-eight of the 49 suspected tears were subsequently surgically explored and repaired. Three patterns of tendon abnormalities were recognized on CT scans: type I-intact, hypertrophied, heterogeneous tendon; type II-attenuated tendon; and type III-absence of a portion of a tendon. Types I and II correlated with partial rupture seen during surgery, and type III correlated with complete rupture of the tendon. CT findings were accurate in 96% of the patients who underwent surgery. In four cases (14%), tendon rupture was seen on CT scans, but the extent of the injury was underestimated and the rupture was misclassified. Reactive periostitis of the distal tibia was seen in 71% of diseased tendons and may represent an important factor in the diagnosis of tendon rupture. 相似文献
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G D Taylor P Kibsey T Kirkland E Burroughs E Tredget 《Burns : journal of the International Society for Burn Injuries》1992,18(4):332-335
To assess the sites, incidence, and bacteriology of infections in intensive care burn patients, a prospective survey of all admissions to a tertiary care institution burn unit was carried out over a 12-month period. One hundred and sixteen patients were admitted, 106 with a diagnosis of thermal burns. Forty patients developed 90 infections. Only two deaths occurred, one in a patient with sepsis. In order of frequency, pneumonia, burn infection, UTI and primary bacteraemia were most common. Staphylococcal species accounted for a majority of infections at all body sites except UTI (47 per cent of all infections, including 11 of 14 bacteraemic infections). Staph. aureus sepsis was more common in those carrying the organism on admission. Strain typing of paired admission and subsequent clinical isolates in 19 patients with Staph. aureus sepsis indicated that eight (42 per cent) became infected with a strain they carried on admission. Further reductions in septic complications of burns in our center would be best directed at staphylococcal species, particularly Staph. aureus. Both eradication of carrier state, and prevention of acquisition of Staph. aureus strains could be explored. 相似文献
7.
Bradley J Katz John R Burroughs Richard L Anderson Shannon Bownds John D McCann 《Movement disorders》2007,22(2):231-234
We present a patient with a facial movement disorder that has characteristics of both blepharospasm and bilateral asynchronous hemifacial spasm. Because of the increased incidence of blepharospasm in patients with hemifacial spasm, our patient's clinical presentation is probably not a chance occurrence, but rather a manifestation of some predisposition for these two movement disorders. This unusual constellation of signs and symptoms challenges the current diagnostic criteria and suggests that some of these facial movement disorders may lie on a spectrum, rather than represent distinct entities. 相似文献
8.
Peroneus quartus muscle: MR imaging features 总被引:2,自引:0,他引:2
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Detection of IgE-mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride 总被引:10,自引:0,他引:10
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Ovine T-cell lines (including one clone [101A]), which are specific for Bluetongue virus serotype 1 (BTV1), have been established and characterized. Although these T-cell lines react with different isolates of BTV1 (including those from South Africa, Australia, Nigeria, and Cameroon), they do not react with heterologous BTV serotypes. Antigen specificity of these T-cells was studied using purified virus particles, infectious subviral particles (ISVP) and cores, or using individual BTV structural proteins that were either isolated by SDS-PAGE or expressed by recombinant strains of vaccinia virus. The results showed that each of the T-cell lines reacted with outer capsid protein VP2 (the BTV protein exhibiting most serotype-specific variation and the major neutralization antigen). However, all of the uncloned T-cell lines also reacted with either the core structural proteins or the outer capsid protein VP5. In contrast, the T-cell clone 101A only reacted with outer capsid protein VP2. Cell surface marker analysis showed that 101A has a helper T-cell phenotype (CD5+, CD4+, CD8-, T-19-). The T-cell lines and clone 101A all produced large amounts of interleukin 2 (IL-2) when stimulated with purified BTV1 virus particles, or with VP2 (up to 120 IU/ml from 2 x 10(5) T-cells). BTV serotype-specific antigenic sites, for B cells and at least one site for ovine helper T-cells, are therefore located within VP2. 相似文献