排序方式: 共有23条查询结果,搜索用时 15 毫秒
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Livneh Nir Braeken Dionne Drozdinsky Genady Gafter-Gvili Anat Seelig Jaap Rozovski Uri Berger Tamar Raanani Pia Falanga Anna ten Cate Hugo Spectre Galia Leader Avi 《Journal of thrombosis and thrombolysis》2021,52(2):590-596
Journal of Thrombosis and Thrombolysis - Managing anticoagulation in hematological malignancy patients with atrial fibrillation and thrombocytopenia is a clinical challenge with limited data. We... 相似文献
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Kalandadze Tamara Braeken Johan Brynskov Cecilia Næss Kari-Anne Bottegaard 《Journal of autism and developmental disorders》2022,52(1):316-326
Journal of Autism and Developmental Disorders - Poor metaphor comprehension was considered a hallmark of autism spectrum disorder (ASD), but recent research has questioned the extent and the... 相似文献
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D Braeken N Otoo-Oyortey G Serour 《International journal of gynaecology and obstetrics》2007,98(2):172-174
Obstetricians and gynecologists at the FIGO pre-congress workshop on adolescents deliberated on their role as clinicians, educators and advocates in upholding young peoples' sexual and reproductive health rights. Comprehensive services to adolescents should include emergency contraception, safe abortion and also provide care for survivors of sexual violence. Key to successful access to youth friendly services consist of providers' attitudes and addressing consent, confidentiality, evolving capacities of young people and youth participation. 相似文献
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Baxter EW Conway KA Kennis L Bischoff F Mercken MH Winter HL Reynolds CH Tounge BA Luo C Scott MK Huang Y Braeken M Pieters SM Berthelot DJ Masure S Bruinzeel WD Jordan AD Parker MH Boyd RE Qu J Alexander RS Brenneman DE Reitz AB 《Journal of medicinal chemistry》2007,50(18):4261-4264
A new aspartic protease inhibitory chemotype bearing a 2-amino-3,4-dihydroquinazoline ring was identified by high-throughput screening for the inhibition of BACE-1. X-ray crystallography revealed that the exocyclic amino group participated in a hydrogen bonding array with the two catalytic aspartic acids of BACE-1 (Asp(32), Asp(228)). BACE-1 inhibitory potency was increased (0.9 microM to 11 nM K(i)) by substitution into the unoccupied S(1)' pocket. 相似文献
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Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity 总被引:2,自引:0,他引:2
Van Damme P Bogaert E Dewil M Hersmus N Kiraly D Scheveneels W Bockx I Braeken D Verpoorten N Verhoeven K Timmerman V Herijgers P Callewaert G Carmeliet P Van Den Bosch L Robberecht W 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(37):14825-14830
Influx of Ca(2+) ions through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors contributes to neuronal damage in stroke, epilepsy, and neurodegenerative disorders such as ALS. The Ca(2+) permeability of AMPA receptors is largely determined by the glutamate receptor 2 (GluR2) subunit, receptors lacking GluR2 being permeable to Ca(2+) ions. We identified a difference in GluR2 expression in motor neurons from two rat strains, resulting in a difference in vulnerability to AMPA receptor-mediated excitotoxicity both in vitro and in vivo. Astrocytes from the ventral spinal cord were found to mediate this difference in GluR2 expression in motor neurons. The presence of ALS-causing mutant superoxide dismutase 1 in astrocytes abolished their GluR2-regulating capacity and thus affected motor neuron vulnerability to AMPA receptor-mediated excitotoxicity. These results reveal a mechanism through which astrocytes influence neuronal functioning in health and disease. 相似文献